0 10 Inhibition Inhibition NNP 11 13 of of IN 14 15 T t NN 16 20 cell cell NN 21 31 activation activation NN 32 34 by by IN 35 38 the the DT 39 52 extracellular extracellular JJ 53 59 matrix matrix NN 60 67 protein protein NN 68 76 tenascin tenascin NN 76 77 . . . 79 87 Tenascin Tenascin NNP 88 89 ( ( ( 89 91 TN TN NNP 91 92 ) ) ) 93 95 is be VBZ 96 98 an an DT 99 112 extracellular extracellular JJ 113 119 matrix matrix NN 120 127 protein protein NN 128 132 that that WDT 133 135 is be VBZ 136 145 expressed express VBN 146 152 widely widely RB 153 155 in in IN 156 159 the the DT 160 165 fetus fetus NN 166 169 and and CC 170 179 sparingly sparingly RB 180 182 in in IN 183 186 the the DT 187 192 adult adult JJ 192 193 , , , 194 197 but but CC 198 207 reappears reappear VBZ 208 210 at at IN 211 215 high high JJ 216 222 levels level NNS 223 225 in in IN 226 233 certain certain JJ 234 239 areas area NNS 240 242 of of IN 243 249 tissue tissue NN 250 256 insult insult NN 257 261 such such JJ 262 264 as as IN 265 270 tumor tumor NN 271 279 matrices matrix NNS 280 283 and and CC 284 289 sites site NNS 290 292 of of IN 293 298 wound wound NN 299 306 healing healing NN 306 307 . . . 308 310 We we PRP 311 315 show show VBP 316 320 here here RB 321 325 that that IN 326 333 soluble soluble JJ 334 336 TN tn NN 337 345 inhibits inhibit VBZ 346 359 proliferation proliferation NN 360 362 of of IN 363 368 human human JJ 369 370 T t NN 371 376 cells cell NNS 377 379 in in IN 380 388 response response NN 389 391 to to TO 392 397 alpha alpha NN 398 401 CD3 CD3 NNP 402 404 Ab Ab NNP 405 419 co-immobilized co-immobilize VBN 420 424 with with IN 425 428 the the DT 429 442 extracellular extracellular JJ 443 449 matrix matrix NN 450 457 protein protein NN 458 469 fibronectin fibronectin NN 470 471 ( ( ( 471 473 FN FN NNP 473 474 ) ) ) 474 475 . . . 476 478 TN TN NNP 479 483 also also RB 484 492 inhibits inhibit VBZ 493 506 proliferation proliferation NN 507 513 driven drive VBN 514 516 by by IN 517 522 alpha alpha NN 523 531 CD3/IL-2 cd3/il-2 NN 532 534 or or CC 535 537 by by IN 538 545 phorbol phorbol NN 546 556 ester/IL-2 ester/il-2 NN 556 557 , , , 558 561 and and CC 562 564 it it PRP 565 573 prevents prevent VBZ 574 578 high high JJ 579 584 level level NN 585 594 induction induction NN 595 597 of of IN 598 603 IL-2R IL-2R NNP 603 604 . . . 605 608 The the DT 609 617 presence presence NN 618 620 of of IN 621 623 TN TN NNP 624 626 in in IN 627 634 culture culture NN 635 641 medium medium NN 642 646 does do VBZ 647 650 not not RB 651 661 detectably detectably RB 662 667 alter alter VB 668 671 the the DT 672 679 pattern pattern NN 680 682 of of IN 683 691 tyrosine tyrosine NN 692 707 phosphorylation phosphorylation NN 708 717 resulting result VBG 718 722 from from IN 723 724 T t NN 725 729 cell cell NN 730 740 triggering trigger VBG 741 745 with with IN 746 751 alpha alpha NN 752 755 CD3 cd3 NN 755 756 , , , 757 760 but but CC 761 763 at at IN 764 769 later late JJR 770 774 time time NN 775 781 points point NNS 782 790 prevents prevent VBZ 791 794 the the DT 795 805 appearance appearance NN 806 808 of of IN 809 819 functional functional JJ 820 826 NF-AT1 nf-at1 NN 827 840 transcription transcription NN 841 847 factor factor NN 848 857 complexes complex NNS 858 860 in in IN 861 862 T t NN 863 867 cell cell NN 868 875 nuclear nuclear JJ 876 884 extracts extract NNS 884 885 . . . 886 891 These these DT 892 900 findings finding NNS 901 904 are be VBP 905 915 consistent consistent JJ 916 920 with with IN 921 924 the the DT 925 935 postulated postulate VBN 936 940 role role NN 941 944 for for IN 945 947 TN TN NNP 948 950 as as IN 951 952 a a DT 953 960 natural natural JJ 961 971 antagonist antagonist NN 972 974 to to TO 975 977 FN fn NN 978 984 action action NN 984 985 , , , 986 989 and and CC 990 997 suggest suggest VBP 998 1002 that that IN 1003 1004 T t NN 1005 1009 cell cell NN 1010 1019 responses response NNS 1020 1029 occurring occur VBG 1030 1032 at at IN 1033 1039 tissue tissue NN 1040 1045 sites site NNS 1046 1048 in in IN 1049 1054 which which WDT 1055 1057 TN TN NNP 1058 1060 is be VBZ 1061 1070 expressed express VBN 1071 1076 could could MD 1077 1079 be be VB 1080 1090 influenced influence VBN 1091 1093 by by IN 1094 1097 its its PRP$ 1098 1106 presence presence NN 1106 1107 . . .