0 10 Inhibition Inhibition NNP 11 13 of of IN 14 17 the the DT 18 33 differentiation differentiation NN 34 36 of of IN 37 42 human human JJ 43 50 myeloid myeloid JJ 51 55 cell cell NN 56 61 lines line NNS 62 64 by by IN 65 70 redox redox NN 71 78 changes change NNS 79 86 induced induce VBN 87 94 through through IN 95 106 glutathione glutathione NN 107 116 depletion depletion NN 116 117 . . . 119 121 We we PRP 122 126 have have VBP 127 139 investigated investigate VBN 140 143 the the DT 144 150 effect effect NN 151 153 of of IN 154 159 redox redox NN 160 167 changes change NNS 168 170 in in FW 171 175 vivo vivo FW 176 178 on on IN 179 182 the the DT 183 198 differentiation differentiation NN 199 201 of of IN 202 205 two two CD 206 211 human human JJ 212 219 myeloid myeloid JJ 220 224 cell cell NN 225 230 lines line NNS 230 231 , , , 232 237 HL-60 HL-60 NNP 238 241 and and CC 242 246 KG-1 kg-1 NN 246 247 . . . 248 251 The the DT 252 273 glutathione-depleting glutathione-depleting JJ 274 279 agent agent NN 280 287 diethyl diethyl NN 288 295 maleate maleate NN 296 297 ( ( ( 297 300 DEM DEM NNP 300 301 ) ) ) 302 311 prevented prevent VBD 312 315 the the DT 316 327 development development NN 328 330 of of IN 331 345 differentiated differentiate VBN 346 354 features feature NNS 355 357 in in IN 358 366 response response NN 367 369 to to TO 370 377 phorbol phorbol NN 378 384 esters ester NNS 384 385 , , , 386 395 including include VBG 396 405 adherence adherence NN 406 408 of of IN 409 412 the the DT 413 418 cells cell NNS 419 421 to to TO 422 429 plastic plastic JJ 430 438 surfaces surface NNS 439 442 and and CC 443 453 repression repression NN 454 456 of of IN 457 460 the the DT 461 476 myeloperoxidase myeloperoxidase NN 477 480 and and CC 481 485 CD34 cd34 NN 486 491 genes gene NNS 491 492 . . . 493 501 Moreover moreover RB 501 502 , , , 503 506 DEM DEM NNP 507 516 abolished abolish VBD 517 524 phorbol phorbol NN 525 537 12-myristate 12-myristate NN 538 556 13-acetate-induced 13-acetate-induced JJ 557 567 activation activation NN 568 570 of of IN 571 574 the the DT 575 588 transcription transcription NN 589 596 factors factor NNS 597 601 AP-1 ap-1 NN 602 605 and and CC 606 611 Egr-1 egr-1 NN 611 612 , , , 613 623 suggesting suggest VBG 624 628 that that IN 629 639 inhibition inhibition NN 640 642 of of IN 643 658 differentiation differentiation NN 659 662 may may MD 663 665 be be VB 666 669 due due IN 669 670 , , , 671 673 at at IN 674 679 least least JJS 680 682 in in IN 683 687 part part NN 687 688 , , , 689 691 to to TO 692 697 redox redox VB 698 711 modifications modification NNS 712 714 of of IN 715 720 these these DT 721 729 proteins protein NNS 729 730 . . .