0 3 The the DT 4 6 Ah ah NN 7 15 receptor receptor NN 16 26 recognizes recognize VBZ 27 30 DNA DNA NNP 31 38 binding binding NN 39 44 sites site NNS 45 48 for for IN 49 52 the the DT 53 54 B B NNP 55 59 cell cell NN 60 73 transcription transcription NN 74 80 factor factor NN 80 81 , , , 82 86 BSAP BSAP NNP 86 87 : : : 88 89 a a DT 90 98 possible possible JJ 99 108 mechanism mechanism NN 109 112 for for IN 113 128 dioxin-mediated dioxin-mediated JJ 129 139 alteration alteration NN 140 142 of of IN 143 147 CD19 cd19 NN 148 152 gene gene NN 153 163 expression expression NN 164 166 in in IN 167 172 human human JJ 173 174 B B NNP 175 186 lymphocytes lymphocyte NNS 186 187 . . . 189 224 2,3,7,8-tetrachlorodibenzo-p-dioxin 2,3,7,8-tetrachlorodibenzo-p-dioxin NN 225 226 ( ( ( 226 230 TCDD TCDD NNP 230 231 ) ) ) 232 240 inhibits inhibit VBZ 241 247 murine murine JJ 248 251 and and CC 252 257 human human JJ 258 259 B B NNP 260 270 lymphocyte lymphocyte NN 271 285 immunoglobulin immunoglobulin NN 286 296 production production NN 297 304 through through IN 305 307 an an DT 308 315 unknown unknown JJ 316 325 mechanism mechanism NN 325 326 . . . 327 331 This this DT 332 337 study study NN 338 350 investigated investigate VBD 351 354 the the DT 355 361 effect effect NN 362 364 of of IN 365 369 TCDD TCDD NNP 370 372 on on IN 373 383 expression expression NN 384 386 of of IN 387 390 the the DT 391 395 CD19 cd19 NN 396 400 gene gene NN 401 403 in in IN 404 405 a a DT 406 411 human human JJ 412 413 B B NNP 414 424 lymphocyte lymphocyte NN 425 429 cell cell NN 430 434 line line NN 434 435 . . . 436 444 Northern Northern NNP 445 449 blot blot NN 450 458 analysis analysis NN 459 465 showed show VBD 466 470 that that IN 471 475 TCDD TCDD NNP 476 485 treatment treatment NN 486 495 decreased decrease VBD 496 502 steady steady JJ 503 508 state state NN 509 515 levels level NNS 516 518 of of IN 519 523 CD19 CD19 NNP 524 528 mRNA mRNA NNP 529 531 by by IN 532 534 67 67 CD 534 535 % % NN 536 538 in in IN 539 542 the the DT 543 547 IM-9 IM-9 NNP 548 552 cell cell NN 553 557 line line NN 557 558 . . . 559 564 Using use VBG 565 566 a a DT 567 570 gel gel NN 571 579 mobility mobility NN 580 585 shift shift NN 586 591 assay assay NN 591 592 , , , 593 595 we we PRP 596 606 identified identify VBD 607 608 a a DT 609 620 DNA-binding dna-binding JJ 621 628 complex complex NN 629 631 in in IN 632 636 IM-9 IM-9 NNP 637 644 nuclear nuclear JJ 645 653 extracts extract NNS 654 658 that that IN 659 661 by by IN 662 669 several several JJ 670 678 criteria criterion NNS 679 686 appears appear VBZ 687 689 to to TO 690 692 be be VB 693 696 the the DT 697 699 Ah ah NN 700 708 receptor receptor NN 708 709 . . . 710 712 In in IN 713 721 addition addition NN 721 722 , , , 723 726 the the DT 727 729 Ah ah NN 730 738 receptor receptor NN 739 746 complex complex NN 747 757 recognized recognize VBD 758 759 a a DT 760 763 DNA dna NN 764 771 binding binding NN 772 776 site site NN 777 780 for for IN 781 782 B B NNP 783 787 cell cell NN 788 804 lineage-specific lineage-specific JJ 805 814 activator activator NN 815 822 protein protein NN 823 824 ( ( ( 824 828 BSAP BSAP NNP 828 829 ) ) ) 830 832 in in IN 833 836 the the DT 837 845 promoter promoter NN 846 852 region region NN 853 855 of of IN 856 859 the the DT 860 865 human human JJ 866 870 CD19 cd19 NN 871 875 gene gene NN 876 881 which which WDT 882 884 is be VBZ 885 892 similar similar JJ 893 895 to to TO 896 899 the the DT 900 909 consensus consensus NN 910 912 Ah ah NN 913 921 receptor receptor NN 922 925 DNA dna NN 926 933 binding binding NN 934 938 site site NN 938 939 . . . 940 945 These these DT 946 953 results result NNS 954 961 suggest suggest VBP 962 966 that that IN 967 970 the the DT 971 974 AhR ahr NN 975 980 could could MD 981 990 interfere interfere VB 991 995 with with IN 996 1011 BSAP-stimulated bsap-stimulated JJ 1012 1016 CD19 cd19 NN 1017 1021 gene gene NN 1022 1035 transcription transcription NN 1036 1038 by by IN 1039 1050 competition competition NN 1051 1054 for for IN 1055 1056 a a DT 1057 1063 common common JJ 1064 1067 DNA dna NN 1068 1075 binding binding NN 1076 1080 site site NN 1080 1081 . . .