0 5 IL-10 IL-10 NNP 6 13 induces induce VBZ 14 17 the the DT 18 26 tyrosine tyrosine NN 27 42 phosphorylation phosphorylation NN 43 45 of of IN 46 50 tyk2 tyk2 NN 51 54 and and CC 55 59 Jak1 Jak1 NNP 60 63 and and CC 64 67 the the DT 68 80 differential differential JJ 81 89 assembly assembly NN 90 92 of of IN 93 98 STAT1 stat1 NN 99 104 alpha alpha NN 105 108 and and CC 109 114 STAT3 stat3 NN 115 124 complexes complex NNS 125 127 in in IN 128 133 human human JJ 134 135 T t NN 136 141 cells cell NNS 142 145 and and CC 146 155 monocytes monocyte NNS 155 156 . . . 158 163 IL-10 IL-10 NNP 164 171 affects affect VBZ 172 181 monocytes monocyte NNS 182 185 and and CC 186 187 T t NN 188 193 cells cell NNS 194 196 by by IN 197 204 driving drive VBG 205 208 the the DT 209 220 progression progression NN 221 223 of of IN 224 230 immune immune JJ 231 245 responsiveness responsiveness NN 246 250 such such JJ 251 255 that that IN 256 259 Th2 th2 NN 260 279 lymphocyte-mediated lymphocyte-mediated JJ 280 287 effects effect NNS 288 299 predominate predominate VBP 299 300 . . . 301 303 In in IN 304 308 this this DT 309 315 report report NN 315 316 , , , 317 319 we we PRP 320 324 show show VBP 325 329 that that IN 330 332 in in IN 333 342 monocytes monocyte NNS 343 346 and and CC 347 348 T t NN 349 354 cells cell NNS 355 360 IL-10 il-10 NN 361 371 stimulates stimulate VBZ 372 380 tyrosine tyrosine NN 381 396 phosphorylation phosphorylation NN 397 399 of of IN 400 403 the the DT 404 410 signal signal NN 411 422 transducers transducer NNS 423 426 and and CC 427 437 activators activator NNS 438 440 of of IN 441 454 transcription transcription NN 454 455 , , , 456 461 STAT1 stat1 NN 462 467 alpha alpha NN 468 471 and and CC 472 477 STAT3 stat3 NN 477 478 , , , 479 481 in in IN 482 483 a a DT 484 496 differential differential JJ 497 503 manner manner NN 504 508 such such IN 509 513 that that IN 514 517 the the DT 518 526 relative relative JJ 527 536 formation formation NN 537 539 of of IN 540 545 homo- homo- JJ 546 549 and and CC 550 562 heterodimers heterodimer NNS 563 569 varies vary VBZ 570 577 between between IN 578 581 the the DT 582 585 two two CD 586 590 cell cell NN 591 596 types type NNS 596 597 . . . 598 606 Moreover moreover RB 606 607 , , , 608 617 monocytes monocyte NNS 618 625 express express VBP 626 627 a a DT 628 633 novel novel JJ 634 650 IL-10-stimulated il-10-stimulated JJ 651 655 STAT stat NN 656 663 protein protein NN 664 668 with with IN 669 671 an an DT 672 676 M(r) m(r) NN 677 679 of of IN 680 682 70 70 CD 683 686 kDa kda NN 687 691 that that WDT 692 694 is be VBZ 695 705 recognized recognize VBN 706 708 by by IN 709 712 the the DT 713 723 anti-STAT3 anti-stat3 JJ 724 726 Ab Ab NNP 727 730 but but CC 731 733 is be VBZ 734 737 not not RB 738 746 observed observe VBN 747 749 in in IN 750 751 T t NN 752 757 cells cell NNS 757 758 . . . 759 764 IL-10 IL-10 NNP 765 774 treatment treatment NN 775 777 of of IN 778 782 both both DT 783 784 T t NN 785 790 cells cell NNS 791 794 and and CC 795 804 monocytes monocyte NNS 805 812 results result VBZ 813 815 in in IN 816 819 the the DT 820 834 ligand-induced ligand-induced JJ 835 843 tyrosine tyrosine NN 844 859 phosphorylation phosphorylation NN 860 862 of of IN 863 867 tyk2 tyk2 NN 868 871 and and CC 872 876 Jak1 Jak1 NNP 876 877 , , , 878 881 but but CC 882 885 not not RB 886 890 Jak2 jak2 NN 891 893 or or CC 894 898 Jak3 jak3 NN 898 899 . . . 900 909 Selective selective JJ 910 920 modulation modulation NN 921 923 of of IN 924 930 immune immune JJ 931 945 responsiveness responsiveness NN 946 948 by by IN 949 954 IL-10 il-10 NN 955 957 in in IN 958 963 cells cell NNS 964 968 such such JJ 969 971 as as IN 972 981 monocytes monocyte NNS 982 985 and and CC 986 987 T t NN 988 993 cells cell NNS 994 997 may may MD 998 1004 result result VB 1005 1007 in in IN 1008 1012 part part NN 1013 1017 from from IN 1018 1021 the the DT 1022 1034 differential differential JJ 1035 1045 activation activation NN 1046 1048 of of IN 1049 1053 STAT STAT NNP 1054 1061 protein protein NN 1062 1067 pairs pair NNS 1067 1068 . . .