0	10	Expression	expression	NN
11	13	of	of	IN
14	17	the	the	DT
18	28	nucleoside	nucleoside	NN
29	40	diphosphate	diphosphate	NN
41	47	kinase	kinase	NNP
48	50	in	in	IN
51	56	human	human	JJ
57	61	skin	skin	NN
62	69	cancers	cancer	NNS
69	70	:	:	:
71	73	an	an	DT
74	93	immunohistochemical	immunohistochemical	JJ
94	99	study	study	NN
99	100	.	.	.

102	112	Expression	expression	NN
113	115	of	of	IN
116	126	nucleoside	nucleoside	NN
127	143	diphosphate(NDP)	diphosphate(NDP)	NNP
144	150	kinase	kinase	NNP
150	151	,	,	,
152	157	which	which	WDT
158	160	is	be	VBZ
161	171	homologous	homologous	JJ
172	174	to	to	TO
175	178	the	the	DT
179	183	nm23	nm23	NN
184	188	gene	gene	NN
189	196	product	product	NN
197	199	in	in	IN
200	201	a	a	DT
202	209	variety	variety	NN
210	212	of	of	IN
213	220	species	specie	NNS
220	221	,	,	,
222	225	has	have	VBZ
226	230	been	be	VBN
231	236	found	find	VBN
237	239	to	to	TO
240	242	be	be	VB
243	252	inversely	inversely	RB
253	263	associated	associate	VBN
264	268	with	with	IN
269	279	metastatic	metastatic	JJ
280	289	potential	potential	NN
289	290	.	.	.

291	298	However	however	RB
298	299	,	,	,
300	303	the	the	DT
304	316	relationship	relationship	NN
317	324	remains	remain	VBZ
325	338	controversial	controversial	JJ
339	348	according	accord	VBG
349	351	to	to	TO
352	355	the	the	DT
356	361	tumor	tumor	NN
362	366	cell	cell	NN
367	372	types	type	NNS
373	376	and	and	CC
377	389	experimental	experimental	JJ
390	396	system	system	NN
396	397	,	,	,
398	402	with	with	IN
403	414	conflicting	conflict	VBG
415	422	results	result	NNS
423	427	from	from	IN
428	437	different	different	JJ
438	446	research	research	NN
447	453	groups	group	NNS
453	454	.	.	.

455	457	In	in	IN
458	463	order	order	NN
464	466	to	to	TO
467	476	determine	determine	VB
477	484	whether	whether	IN
485	488	NDP	NDP	NNP
489	495	kinase	kinase	NNP
496	506	expression	expression	NN
507	513	serves	serve	VBZ
514	516	as	as	IN
517	518	a	a	DT
519	525	marker	marker	NN
526	529	for	for	IN
530	540	metastatic	metastatic	JJ
541	550	potential	potential	NN
551	553	in	in	IN
554	559	human	human	JJ
560	564	skin	skin	NN
565	571	cancer	cancer	NN
571	572	,	,	,
573	575	we	we	PRP
576	584	assessed	assess	VBD
585	588	the	the	DT
589	595	levels	level	NNS
596	598	of	of	IN
599	602	NDP	NDP	NNP
603	609	kinase	kinase	NNP
610	620	expression	expression	NN
621	623	in	in	IN
624	625	9	9	CD
626	642	keratoacanthomas	keratoacanthoma	NNS
643	644	(	(	(
644	647	KAs	KA	NNP
647	648	)	)	)
648	649	,	,	,
650	652	26	26	CD
653	661	squamous	squamous	JJ
662	666	cell	cell	NN
667	677	carcinomas	carcinoma	NNS
678	679	(	(	(
679	683	SCCs	SCC	NNP
683	684	)	)	)
684	685	,	,	,
686	689	and	and	CC
690	692	25	25	CD
693	698	basal	basal	JJ
699	703	cell	cell	NN
704	714	carcinomas	carcinoma	NNS
715	716	(	(	(
716	720	BCCs	BCC	NNP
720	721	)	)	)
722	727	using	use	VBG
728	748	immunohistochemistry	immunohistochemistry	NN
748	749	.	.	.

750	753	The	the	DT
754	764	expression	expression	NN
765	767	of	of	IN
768	771	NDP	NDP	NNP
772	778	kinase	kinase	NNP
779	782	was	be	VBD
783	790	intense	intense	JJ
791	793	in	in	IN
794	796	KA	KA	NNP
797	800	and	and	CC
801	804	SCC	SCC	NNP
805	813	compared	compare	VBN
814	818	with	with	IN
819	822	BCC	BCC	NNP
822	823	.	.	.

824	831	However	however	RB
831	832	,	,	,
833	836	the	the	DT
837	847	difference	difference	NN
848	850	of	of	IN
851	854	NDP	NDP	NNP
855	861	kinase	kinase	NNP
862	872	expression	expression	NN
873	880	between	between	IN
881	883	KA	KA	NNP
884	887	and	and	CC
888	891	SCC	SCC	NNP
892	895	was	be	VBD
896	899	not	not	RB
900	913	statistically	statistically	RB
914	925	significant	significant	JJ
925	926	.	.	.

927	930	And	and	CC
931	936	there	there	EX
937	940	was	be	VBD
941	943	no	no	DT
944	957	statistically	statistically	RB
958	969	significant	significant	JJ
970	980	difference	difference	NN
981	983	in	in	IN
984	987	NDP	NDP	NNP
988	994	kinase	kinase	NNP
995	1005	expression	expression	NN
1006	1013	between	between	IN
1014	1017	SCC	SCC	NNP
1018	1022	with	with	IN
1023	1033	metastasis	metastasis	NN
1034	1037	and	and	CC
1038	1041	SCC	SCC	NNP
1042	1049	without	without	IN
1050	1060	metastasis	metastasis	NN
1060	1061	.	.	.

1062	1065	Our	our	PRP$
1066	1073	results	result	NNS
1074	1084	contradict	contradict	VBP
1085	1088	the	the	DT
1089	1099	hypothesis	hypothesis	NN
1100	1110	concerning	concern	VBG
1111	1114	the	the	DT
1115	1123	possible	possible	JJ
1124	1128	role	role	NN
1129	1131	of	of	IN
1132	1136	nm23	nm23	NN
1137	1141	gene	gene	NN
1142	1144	as	as	IN
1145	1146	a	a	DT
1147	1157	metastatic	metastatic	JJ
1158	1168	suppressor	suppressor	NN
1169	1173	gene	gene	NN
1174	1176	in	in	IN
1177	1182	human	human	JJ
1183	1187	skin	skin	NN
1188	1194	cancer	cancer	NN
1194	1195	.	.	.

1196	1199	The	the	DT
1200	1209	mechanism	mechanism	NN
1210	1212	of	of	IN
1213	1227	overexpression	overexpression	NN
1228	1230	in	in	IN
1231	1238	various	various	JJ
1239	1244	tumor	tumor	NN
1245	1249	cell	cell	NN
1250	1255	types	type	NNS
1256	1259	and	and	CC
1260	1263	its	its	PRP$
1264	1274	biological	biological	JJ
1275	1287	significance	significance	NN
1288	1290	in	in	IN
1291	1300	cutaneous	cutaneous	JJ
1301	1315	carcinogenesis	carcinogenesis	NN
1316	1322	remain	remain	VBP
1323	1325	to	to	TO
1326	1328	be	be	VB
1329	1339	determined	determine	VBN
1339	1340	.	.	.