0 9 Prolactin Prolactin NNP 10 13 and and CC 14 27 interleukin-2 interleukin-2 NN 28 37 receptors receptor NNS 38 40 in in IN 41 42 T t NN 43 54 lymphocytes lymphocyte NNS 55 61 signal signal VBP 62 69 through through IN 70 71 a a DT 72 86 MGF-STAT5-like mgf-stat5-like JJ 87 100 transcription transcription NN 101 107 factor factor NN 107 108 . . . 110 113 The the DT 114 118 cell cell NN 119 126 surface surface NN 127 136 receptors receptor NNS 137 140 for for IN 141 144 PRL PRL NNP 145 148 and and CC 149 162 interleukin-2 interleukin-2 NN 163 164 ( ( ( 164 168 IL-2 il-2 NN 168 169 ) ) ) 170 173 are be VBP 174 186 structurally structurally RB 187 195 distinct distinct JJ 195 196 , , , 197 200 but but CC 201 206 share share VBP 207 217 regulatory regulatory JJ 218 223 tasks task NNS 224 226 in in IN 227 228 T t NN 229 240 lymphocytes lymphocyte NNS 240 241 . . . 242 246 They they PRP 247 250 can can MD 251 260 stimulate stimulate VB 261 274 proliferation proliferation NN 275 278 and and CC 279 287 activate activate VBP 288 301 transcription transcription NN 302 304 of of IN 305 317 over-lapping over-lapping JJ 318 322 sets set NNS 323 325 of of IN 326 331 genes gene NNS 332 334 of of IN 335 336 T t NN 337 342 cells cell NNS 342 343 . . . 344 347 PRL PRL NNP 348 351 and and CC 352 356 IL-2 il-2 NN 357 365 receptor receptor NN 366 376 activation activation NN 377 380 are be VBP 381 385 both both DT 386 392 linked link VBN 393 395 to to TO 396 399 the the DT 400 408 Jak/Stat Jak/Stat NNP 409 410 ( ( ( 410 416 signal signal NN 417 427 transducer transducer NN 428 431 and and CC 432 441 activator activator NN 442 444 of of IN 445 458 transcription transcription NN 458 459 ) ) ) 460 467 pathway pathway NN 467 468 . . . 469 471 We we PRP 472 484 investigated investigate VBD 485 488 the the DT 489 496 ability ability NN 497 499 of of IN 500 503 PRL PRL NNP 504 507 and and CC 508 512 IL-2 il-2 NN 513 515 to to TO 516 524 activate activate VB 525 529 Stat Stat NNP 530 538 proteins protein NNS 539 541 in in IN 542 551 different different JJ 552 553 T t NN 554 558 cell cell NN 559 564 lines line NNS 564 565 . . . 566 569 The the DT 570 573 DNA dna NN 574 581 binding binding NN 582 595 specificities specificity NNS 595 596 , , , 597 600 the the DT 601 613 reactivities reactivity NNS 614 620 toward toward IN 621 634 Stat-specific stat-specific JJ 635 643 antisera antiserum NNS 643 644 , , , 645 648 and and CC 649 652 the the DT 653 656 mol mol NN 657 659 wt wt NN 660 662 of of IN 663 668 IL-2- IL-2- NNP 669 672 and and CC 673 684 PRL-induced prl-induced JJ 685 696 DNA-binding dna-binding JJ 697 705 proteins protein NNS 706 708 in in IN 709 712 Nb2 Nb2 NNP 713 716 and and CC 717 721 C196 C196 NNP 722 723 T t NN 724 728 cell cell NN 729 734 lines line NNS 735 739 were be VBD 740 752 investigated investigate VBN 752 753 . . . 754 755 A a DT 756 766 comparison comparison NN 767 771 with with IN 772 775 the the DT 776 780 Stat Stat NNP 781 789 proteins protein NNS 790 797 induced induce VBN 798 800 by by IN 801 817 interferon-gamma interferon-gamma NN 817 818 , , , 819 822 PRL PRL NNP 822 823 , , , 824 827 and and CC 828 832 IL-6 IL-6 NNP 833 835 in in IN 836 840 T47D T47D NNP 841 848 mammary mammary JJ 849 854 tumor tumor NN 855 860 cells cell NNS 861 864 was be VBD 865 869 made make VBN 869 870 . . . 871 873 We we PRP 874 879 found find VBD 880 884 that that IN 885 890 these these DT 891 901 parameters parameter NNS 902 906 were be VBD 907 924 indistinguishable indistinguishable JJ 925 928 for for IN 929 932 one one CD 933 935 of of IN 936 939 the the DT 940 944 PRL- prl- NN 945 948 and and CC 949 961 IL-2-induced il-2-induced JJ 962 969 factors factor NNS 969 970 . . . 971 972 A a DT 973 986 transcription transcription NN 987 993 factor factor NN 994 1001 closely closely RB 1002 1009 related related JJ 1010 1012 to to TO 1013 1020 mammary mammary JJ 1021 1026 gland gland NN 1027 1039 factor-Stat5 factor-stat5 NN 1040 1042 is be VBZ 1043 1050 rapidly rapidly RB 1051 1060 activated activate VBN 1061 1065 upon upon IN 1066 1077 interaction interaction NN 1078 1080 of of IN 1081 1085 IL-2 IL-2 NNP 1086 1089 and and CC 1090 1093 PRL PRL NNP 1094 1098 with with IN 1099 1104 their their PRP$ 1105 1115 respective respective JJ 1116 1125 receptors receptor NNS 1125 1126 . . . 1127 1137 Activation Activation NNP 1138 1140 of of IN 1141 1142 a a DT 1143 1149 second second JJ 1150 1157 protein protein NN 1158 1165 related relate VBN 1166 1168 to to TO 1169 1174 Stat1 Stat1 NNP 1175 1178 was be VBD 1179 1183 also also RB 1184 1192 observed observe VBN 1192 1193 . . . 1194 1197 Our our PRP$ 1198 1205 results result NNS 1206 1215 emphasize emphasize VBP 1216 1219 the the DT 1220 1224 role role NN 1225 1227 of of IN 1228 1231 PRL PRL NNP 1232 1234 as as IN 1235 1236 a a DT 1237 1246 regulator regulator NN 1247 1249 of of IN 1250 1253 the the DT 1254 1260 immune immune JJ 1261 1269 response response NN 1270 1273 and and CC 1274 1282 indicate indicate VBP 1283 1287 that that IN 1288 1291 the the DT 1292 1296 Stat Stat NNP 1297 1304 factors factor NNS 1305 1312 mammary mammary JJ 1313 1318 gland gland NN 1319 1331 factor-Stat5 factor-stat5 NN 1332 1335 and and CC 1336 1341 Stat1 Stat1 NNP 1342 1346 play play VBP 1347 1348 a a DT 1349 1353 role role NN 1354 1356 in in IN 1357 1360 the the DT 1361 1371 regulation regulation NN 1372 1374 of of IN 1375 1379 gene gene NN 1380 1390 expression expression NN 1391 1397 during during IN 1398 1399 T t NN 1400 1404 cell cell NN 1405 1416 development development NN 1416 1417 . . .