0 3 E1A E1A NNP 4 8 gene gene NN 9 19 expression expression NN 20 27 induces induce VBZ 28 42 susceptibility susceptibility NN 43 45 to to TO 46 53 killing killing NN 54 56 by by IN 57 59 NK NK NNP 60 65 cells cell NNS 66 75 following follow VBG 76 91 immortalization immortalization NN 92 95 but but CC 96 99 not not RB 100 110 adenovirus adenovirus NN 111 120 infection infection NN 121 123 of of IN 124 129 human human JJ 130 135 cells cell NNS 135 136 . . . 138 148 Adenovirus Adenovirus NNP 149 150 ( ( ( 150 152 Ad Ad NNP 152 153 ) ) ) 154 163 infection infection NN 164 167 and and CC 168 171 E1A E1A NNP 172 184 transfection transfection NN 185 189 were be VBD 190 194 used use VBN 195 197 to to TO 198 203 model model VB 204 211 changes change NNS 212 214 in in IN 215 229 susceptibility susceptibility NN 230 232 to to TO 233 235 NK NK NNP 236 240 cell cell NN 241 248 killing killing NN 249 255 caused cause VBN 256 258 by by IN 259 268 transient transient JJ 269 271 vs vs IN 272 278 stable stable JJ 279 282 E1A E1A NNP 283 293 expression expression NN 294 296 in in IN 297 302 human human JJ 303 308 cells cell NNS 308 309 . . . 310 314 Only only RB 315 321 stably stably RB 322 333 transfected transfecte VBN 334 340 target target NN 341 346 cells cell NNS 347 356 exhibited exhibit VBD 357 366 cytolytic cytolytic JJ 367 381 susceptibility susceptibility NN 381 382 , , , 383 390 despite despite IN 391 401 expression expression NN 402 404 of of IN 405 415 equivalent equivalent JJ 416 422 levels level NNS 423 425 of of IN 426 429 E1A E1A NNP 430 438 proteins protein NNS 439 441 in in IN 442 453 Ad-infected ad-infected JJ 454 461 targets target NNS 461 462 . . . 463 466 The the DT 467 476 inability inability NN 477 479 of of IN 480 483 E1A E1A NNP 484 488 gene gene NN 489 497 products product NNS 498 500 to to TO 501 507 induce induce VB 508 517 cytolytic cytolytic JJ 518 532 susceptibility susceptibility NN 533 539 during during IN 540 549 infection infection NN 550 553 was be VBD 554 557 not not RB 558 567 explained explain VBN 568 570 by by IN 571 573 an an DT 574 584 inhibitory inhibitory JJ 585 591 effect effect NN 592 594 of of IN 595 600 viral viral JJ 601 610 infection infection NN 611 613 on on IN 614 623 otherwise otherwise RB 624 635 susceptible susceptible JJ 636 642 target target NN 643 648 cells cell NNS 649 651 or or CC 652 654 by by IN 655 660 viral viral JJ 661 665 gene gene NN 666 673 effects effect NNS 674 676 on on IN 677 682 class class NN 683 684 I i CD 685 688 MHC MHC NNP 689 696 antigen antigen NN 697 707 expression expression NN 708 710 on on IN 711 717 target target NN 718 723 cells cell NNS 723 724 . . . 725 729 This this DT 730 742 differential differential JJ 743 749 effect effect NN 750 752 of of IN 753 756 E1A E1A NNP 757 767 expression expression NN 768 770 on on IN 771 774 the the DT 775 784 cytolytic cytolytic JJ 785 795 phenotypes phenotype NNS 796 798 of of IN 799 807 infected infected JJ 808 811 and and CC 812 818 stably stably RB 819 830 transfected transfecte VBN 831 836 human human JJ 837 842 cells cell NNS 843 851 suggests suggest VBZ 852 856 that that IN 857 862 human human JJ 863 865 NK nk NN 866 871 cells cell NNS 872 879 provide provide VBP 880 882 an an DT 883 892 effective effective JJ 893 904 immunologic immunologic JJ 905 912 barrier barrier NN 913 920 against against IN 921 924 the the DT 925 927 in in FW 928 932 vivo vivo FW 933 941 survival survival NN 942 945 and and CC 946 956 neoplastic neoplastic JJ 957 968 progression progression NN 969 971 of of IN 972 988 E1A-immortalized e1a-immortalized JJ 989 994 cells cell NNS 995 999 that that WDT 1000 1003 may may MD 1004 1010 emerge emerge VB 1011 1015 from from IN 1016 1019 the the DT 1020 1029 reservoir reservoir NN 1030 1032 of of IN 1033 1045 persistently persistently RB 1046 1054 infected infected JJ 1055 1060 cells cell NNS 1061 1063 in in IN 1064 1067 the the DT 1068 1073 human human JJ 1074 1078 host host NN 1078 1079 . . .