0	11	Interleukin	Interleukin	NNP
12	14	12	12	CD
15	22	induces	induce	VBZ
23	31	tyrosine	tyrosine	NN
32	47	phosphorylation	phosphorylation	NN
48	51	and	and	CC
52	62	activation	activation	NN
63	65	of	of	IN
66	71	STAT4	stat4	NN
72	74	in	in	IN
75	80	human	human	JJ
81	92	lymphocytes	lymphocyte	NNS
92	93	.	.	.

95	106	Interleukin	Interleukin	NNP
107	109	12	12	CD
110	111	(	(	(
111	116	IL-12	il-12	NN
116	117	)	)	)
118	120	is	be	VBZ
121	123	an	an	DT
124	133	important	important	JJ
134	150	immunoregulatory	immunoregulatory	JJ
151	159	cytokine	cytokine	NN
160	165	whose	whose	WP$
166	174	receptor	receptor	NN
175	177	is	be	VBZ
178	179	a	a	DT
180	186	member	member	NN
187	189	of	of	IN
190	193	the	the	DT
194	207	hematopoietin	hematopoietin	NN
208	216	receptor	receptor	NN
217	228	superfamily	superfamily	NN
228	229	.	.	.

230	232	We	we	PRP
233	237	have	have	VBP
238	246	recently	recently	RB
247	259	demonstrated	demonstrate	VBN
260	264	that	that	IN
265	276	stimulation	stimulation	NN
277	279	of	of	IN
280	285	human	human	JJ
286	287	T	t	NN
288	291	and	and	CC
292	299	natural	natural	JJ
300	306	killer	killer	NN
307	312	cells	cell	NNS
313	317	with	with	IN
318	323	IL-12	il-12	NN
324	331	induces	induce	VBZ
332	340	tyrosine	tyrosine	NN
341	356	phosphorylation	phosphorylation	NN
357	359	of	of	IN
360	363	the	the	DT
364	369	Janus	Janus	NNP
370	376	family	family	NN
377	385	tyrosine	tyrosine	NN
386	392	kinase	kinase	NNP
393	397	JAK2	JAK2	NNP
398	401	and	and	CC
402	406	Tyk2	Tyk2	NNP
406	407	,	,	,
408	419	implicating	implicate	VBG
420	425	these	these	DT
426	433	kinases	kinase	NNS
434	436	in	in	IN
437	440	the	the	DT
441	450	immediate	immediate	JJ
451	462	biochemical	biochemical	JJ
463	471	response	response	NN
472	474	to	to	TO
475	480	IL-12	il-12	NN
480	481	.	.	.

482	490	Recently	recently	RB
490	491	,	,	,
492	505	transcription	transcription	NN
506	513	factors	factor	NNS
514	519	known	know	VBN
520	522	as	as	IN
523	528	STATs	STAT	NNP
529	530	(	(	(
530	536	signal	signal	NN
537	548	transducers	transducer	NNS
549	552	and	and	CC
553	563	activators	activator	NNS
564	566	of	of	IN
567	580	transcription	transcription	NN
580	581	)	)	)
582	586	have	have	VBP
587	591	been	be	VBN
592	597	shown	show	VBN
598	600	to	to	TO
601	603	be	be	VB
604	612	tyrosine	tyrosine	NN
613	627	phosphorylated	phosphorylated	JJ
628	631	and	and	CC
632	641	activated	activate	VBN
642	644	in	in	IN
645	653	response	response	NN
654	656	to	to	TO
657	658	a	a	DT
659	665	number	number	NN
666	668	of	of	IN
669	678	cytokines	cytokine	NNS
679	683	that	that	WDT
684	688	bind	bind	VBP
689	702	hematopoietin	hematopoietin	NN
703	712	receptors	receptor	NNS
713	716	and	and	CC
717	725	activate	activate	VBP
726	729	JAK	JAK	NNP
730	737	kinases	kinase	NNS
737	738	.	.	.

739	741	In	in	IN
742	746	this	this	DT
747	753	report	report	NN
754	756	we	we	PRP
757	768	demonstrate	demonstrate	VBP
769	773	that	that	IN
774	779	IL-12	il-12	NN
780	787	induces	induce	VBZ
788	796	tyrosine	tyrosine	NN
797	812	phosphorylation	phosphorylation	NN
813	815	of	of	IN
816	817	a	a	DT
818	826	recently	recently	RB
827	837	identified	identify	VBN
838	842	STAT	STAT	NNP
843	849	family	family	NN
850	856	member	member	NN
856	857	,	,	,
858	863	STAT4	STAT4	NNP
863	864	,	,	,
865	868	and	and	CC
869	873	show	show	VBP
874	878	that	that	IN
879	884	STAT4	stat4	NN
885	895	expression	expression	NN
896	898	is	be	VBZ
899	908	regulated	regulate	VBN
909	911	by	by	IN
912	918	T-cell	t-cell	NN
919	929	activation	activation	NN
929	930	.	.	.

931	942	Furthermore	furthermore	RB
942	943	,	,	,
944	946	we	we	PRP
947	951	show	show	VBP
952	956	that	that	IN
957	962	IL-12	il-12	NN
963	973	stimulates	stimulate	VBZ
974	983	formation	formation	NN
984	986	of	of	IN
987	988	a	a	DT
989	1000	DNA-binding	dna-binding	JJ
1001	1008	complex	complex	NN
1009	1013	that	that	WDT
1014	1024	recognizes	recognize	VBZ
1025	1026	a	a	DT
1027	1030	DNA	dna	NN
1031	1039	sequence	sequence	NN
1040	1050	previously	previously	RB
1051	1056	shown	show	VBN
1057	1059	to	to	TO
1060	1064	bind	bind	VB
1065	1069	STAT	stat	NN
1070	1078	proteins	protein	NNS
1079	1082	and	and	CC
1083	1087	that	that	IN
1088	1092	this	this	DT
1093	1100	complex	complex	NN
1101	1109	contains	contain	VBZ
1110	1115	STAT4	stat4	NN
1115	1116	.	.	.

1117	1122	These	these	DT
1123	1127	data	datum	NNS
1127	1128	,	,	,
1129	1132	and	and	CC
1133	1136	the	the	DT
1137	1143	recent	recent	JJ
1144	1157	demonstration	demonstration	NN
1158	1160	of	of	IN
1161	1164	JAK	JAK	NNP
1165	1180	phosphorylation	phosphorylation	NN
1181	1183	by	by	IN
1184	1189	IL-12	il-12	NN
1189	1190	,	,	,
1191	1199	identify	identify	VBP
1200	1201	a	a	DT
1202	1207	rapid	rapid	JJ
1208	1227	signal-transduction	signal-transduction	NN
1228	1235	pathway	pathway	NN
1236	1242	likely	likely	JJ
1243	1245	to	to	TO
1246	1253	mediate	mediate	VB
1254	1267	IL-12-induced	il-12-induced	JJ
1268	1272	gene	gene	NN
1273	1283	expression	expression	NN
1283	1284	.	.	.