0 10 Expression expression NN 11 13 of of IN 14 32 erythroid-specific erythroid-specific JJ 33 38 genes gene NNS 39 41 in in IN 42 47 acute acute JJ 48 64 megakaryoblastic megakaryoblastic JJ 65 74 leukaemia leukaemia NN 75 78 and and CC 79 88 transient transient JJ 89 107 myeloproliferative myeloproliferative JJ 108 116 disorder disorder NN 117 119 in in IN 120 124 Down Down NNP 124 126 ’s 's POS 127 135 syndrome syndrome NN 135 136 . . . 138 143 Acute acute JJ 144 160 megakaryoblastic megakaryoblastic JJ 161 170 leukaemia leukaemia NN 171 172 ( ( ( 172 174 M7 M7 NNP 174 175 ) ) ) 176 179 and and CC 180 189 transient transient JJ 190 208 myeloproliferative myeloproliferative JJ 209 217 disorder disorder NN 218 220 in in IN 221 225 Down Down NNP 225 227 ’s 's POS 228 236 syndrome syndrome NN 237 238 ( ( ( 238 241 TMD TMD NNP 241 242 ) ) ) 243 246 are be VBP 247 260 characterized characterize VBN 261 263 by by IN 264 269 rapid rapid JJ 270 276 growth growth NN 277 279 of of IN 280 288 abnormal abnormal JJ 289 294 blast blast NN 295 300 cells cell NNS 301 306 which which WDT 307 314 express express VBP 315 329 megakaryocytic megakaryocytic JJ 330 337 markers marker NNS 337 338 . . . 339 341 To to TO 342 349 clarify clarify VB 350 360 properties property NNS 361 363 of of IN 364 367 the the DT 368 373 blast blast NN 374 379 cells cell NNS 380 382 in in IN 383 385 M7 M7 NNP 386 389 and and CC 390 393 TMD TMD NNP 394 399 cases case NNS 399 400 , , , 401 403 we we PRP 404 412 examined examine VBD 413 422 erythroid erythroid JJ 423 430 markers marker NNS 431 441 expression expression NN 442 444 in in IN 445 451 blasts blast NNS 452 456 from from IN 457 460 six six CD 461 466 cases case NNS 467 471 with with IN 472 474 M7 m7 NN 475 478 and and CC 479 484 seven seven CD 485 490 cases case NNS 491 495 with with IN 496 499 TMD TMD NNP 500 502 in in IN 503 507 this this DT 508 513 study study NN 513 514 . . . 515 533 Erythroid-specific erythroid-specific JJ 534 539 mRNAs mrna NNS 540 548 encoding encode VBG 549 561 gamma-globin gamma-globin NN 562 565 and and CC 566 575 erythroid erythroid JJ 576 597 delta-aminolevulinate delta-aminolevulinate NN 598 606 synthase synthase NN 607 611 were be VBD 612 617 found find VBN 618 620 to to TO 621 623 be be VB 624 633 expressed express VBN 634 636 in in IN 637 643 blasts blast NNS 644 648 from from IN 649 653 most most JJS 654 656 of of IN 657 662 these these DT 663 668 cases case NNS 668 669 , , , 670 680 indicating indicate VBG 681 685 that that IN 686 696 majorities majority NNS 697 699 of of IN 700 703 the the DT 704 710 blasts blast NNS 711 713 in in IN 714 716 M7 M7 NNP 717 720 and and CC 721 724 TMD TMD NNP 725 730 cases case NNS 731 735 have have VBP 736 745 erythroid erythroid JJ 746 749 and and CC 750 764 megakaryocytic megakaryocytic JJ 765 775 phenotypes phenotype NNS 775 776 . . . 777 779 We we PRP 780 784 also also RB 785 790 found find VBD 791 795 that that IN 796 801 mRNAs mrna NNS 802 810 encoding encode VBG 811 817 GATA-1 gata-1 NN 818 821 and and CC 822 828 GATA-2 gata-2 NN 829 832 are be VBP 833 842 expressed express VBN 843 845 in in IN 846 849 all all PDT 850 855 these these DT 856 861 cases case NNS 861 862 . . . 863 868 These these DT 869 876 results result NNS 877 884 suggest suggest VBP 885 889 that that IN 890 892 M7 m7 NN 893 899 blasts blast NNS 900 903 and and CC 904 907 TMD tmd NN 908 914 blasts blast NNS 915 925 correspond correspond VBP 926 928 to to TO 929 932 the the DT 933 957 erythroid/megakaryocytic erythroid/megakaryocytic JJ 958 969 bipotential bipotential JJ 970 980 progenitor progenitor NN 981 986 cells cell NNS 986 987 . . .