0	4	Cell	cell	NN
5	10	type-	type-	NN
11	14	and	and	CC
15	29	stage-specific	stage-specific	JJ
30	40	expression	expression	NN
41	43	of	of	IN
44	47	the	the	DT
48	55	CD20/B1	cd20/b1	NN
56	63	antigen	antigen	NN
64	74	correlates	correlate	VBZ
75	79	with	with	IN
80	83	the	the	DT
84	92	activity	activity	NN
93	95	of	of	IN
96	97	a	a	DT
98	106	diverged	diverged	JJ
107	114	octamer	octamer	NN
115	118	DNA	dna	NN
119	124	motif	motif	NN
125	132	present	present	JJ
133	135	in	in	IN
136	139	its	its	PRP$
140	148	promoter	promoter	NN
148	149	.	.	.

151	154	The	the	DT
155	163	CD20(B1)	cd20(b1)	NN
164	168	gene	gene	NN
169	176	encodes	encode	VBZ
177	178	a	a	DT
179	180	B	B	NNP
181	194	cell-specific	cell-specific	JJ
195	202	protein	protein	NN
203	211	involved	involve	VBN
212	214	in	in	IN
215	218	the	the	DT
219	229	regulation	regulation	NN
230	232	of	of	IN
233	238	human	human	JJ
239	240	B	B	NNP
241	245	cell	cell	NN
246	259	proliferation	proliferation	NN
260	263	and	and	CC
264	279	differentiation	differentiation	NN
279	280	.	.	.

281	288	Studies	study	NNS
289	293	with	with	IN
294	295	5	5	CD
295	296	’	'	SYM
297	305	deletion	deletion	NN
306	310	CD20	cd20	NN
311	323	promoter-CAT	promoter-cat	NN
324	334	constructs	construct	NNS
335	339	have	have	VBP
340	350	previously	previously	RB
351	359	revealed	reveal	VBN
360	363	two	two	CD
364	371	regions	region	NNS
372	374	of	of	IN
375	378	the	the	DT
379	387	promoter	promoter	NN
388	395	between	between	IN
396	401	bases	base	NNS
402	406	-186	-186	CD
407	410	and	and	CC
411	415	-280	-280	CD
416	419	and	and	CC
420	427	between	between	IN
428	433	bases	base	NNS
434	438	-280	-280	CD
439	442	and	and	CC
443	447	-454	-454	CD
448	453	which	which	WDT
454	463	contained	contain	VBD
464	472	positive	positive	JJ
473	483	regulatory	regulatory	JJ
484	492	elements	element	NNS
492	493	.	.	.

494	496	In	in	IN
497	501	this	this	DT
502	507	study	study	NN
508	510	we	we	PRP
511	521	identified	identify	VBD
522	523	a	a	DT
524	532	sequence	sequence	NN
533	540	element	element	NN
541	548	present	present	JJ
549	551	in	in	IN
552	555	the	the	DT
556	560	most	most	RBS
561	569	proximal	proximal	JJ
570	576	region	region	NN
577	584	located	located	JJ
585	592	between	between	IN
593	598	bases	base	NNS
599	603	-214	-214	CD
604	607	and	and	CC
608	612	-201	-201	CD
612	613	,	,	,
614	627	TTCTTCTAATTAA	TTCTTCTAATTAA	NNP
627	628	,	,	,
629	634	which	which	WDT
635	637	is	be	VBZ
638	647	important	important	JJ
648	650	in	in	IN
651	654	the	the	DT
655	659	high	high	JJ
660	672	constitutive	constitutive	JJ
673	683	expression	expression	NN
684	686	of	of	IN
687	691	CD20	CD20	NNP
692	694	in	in	IN
695	701	mature	mature	JJ
702	703	B	B	NNP
704	709	cells	cell	NNS
710	713	and	and	CC
714	717	the	the	DT
718	727	induction	induction	NN
728	730	of	of	IN
731	735	CD20	CD20	NNP
736	738	in	in	IN
739	744	pre-B	pre-b	JJ
745	750	cells	cell	NNS
750	751	.	.	.

752	756	This	this	DT
757	765	sequence	sequence	NN
766	773	element	element	NN
774	777	was	be	VBD
778	786	referred	refer	VBN
787	789	to	to	TO
790	792	as	as	IN
793	796	the	the	DT
797	800	BAT	BAT	NNP
801	804	box	box	NN
805	808	and	and	CC
809	812	its	its	PRP$
813	821	deletion	deletion	NN
822	835	significantly	significantly	RB
836	843	reduced	reduce	VBD
844	847	the	the	DT
848	856	activity	activity	NN
857	859	of	of	IN
860	861	a	a	DT
862	866	CD20	CD20	NNP
867	879	promoter-CAT	promoter-cat	NN
880	889	construct	construct	NN
890	892	in	in	IN
893	894	B	B	NNP
895	900	cells	cell	NNS
900	901	.	.	.

902	910	Mobility	mobility	NN
911	916	shift	shift	NN
917	923	assays	assay	NNS
924	928	with	with	IN
929	936	various	various	JJ
937	943	mutant	mutant	JJ
944	950	probes	probe	NNS
951	954	and	and	CC
955	956	B	B	NNP
957	961	cell	cell	NN
962	969	nuclear	nuclear	JJ
970	978	extracts	extract	NNS
979	991	demonstrated	demonstrate	VBD
992	996	that	that	IN
997	1000	the	the	DT
1001	1005	core	core	NN
1006	1014	sequence	sequence	NN
1015	1019	TAAT	TAAT	NNP
1020	1023	was	be	VBD
1024	1033	essential	essential	JJ
1034	1037	for	for	IN
1038	1045	binding	bind	VBG
1046	1048	to	to	TO
1049	1053	this	this	DT
1054	1058	site	site	NN
1058	1059	.	.	.

1060	1065	Cross	Cross	NNP
1066	1077	competition	competition	NN
1078	1089	experiments	experiment	NNS
1090	1094	with	with	IN
1095	1097	an	an	DT
1098	1105	octamer	octamer	NN
1106	1114	sequence	sequence	NN
1115	1119	from	from	IN
1120	1123	the	the	DT
1124	1126	Ig	Ig	NNP
1127	1132	heavy	heavy	JJ
1133	1138	chain	chain	NN
1139	1147	promoter	promoter	NN
1147	1148	,	,	,
1149	1152	the	the	DT
1153	1156	BAT	BAT	NNP
1157	1160	box	box	NN
1160	1161	,	,	,
1162	1165	and	and	CC
1166	1167	a	a	DT
1168	1175	TA-rich	ta-rich	JJ
1176	1184	sequence	sequence	NN
1185	1192	present	present	JJ
1193	1195	in	in	IN
1196	1199	the	the	DT
1200	1204	CD21	cd21	NN
1205	1213	promoter	promoter	NN
1214	1222	revealed	reveal	VBD
1223	1227	that	that	IN
1228	1231	all	all	DT
1232	1237	three	three	CD
1238	1247	sequences	sequence	NNS
1248	1253	bound	bind	VBD
1254	1257	the	the	DT
1258	1262	same	same	JJ
1263	1270	nuclear	nuclear	JJ
1271	1279	proteins	protein	NNS
1280	1290	suggesting	suggest	VBG
1291	1295	that	that	IN
1296	1299	the	the	DT
1300	1303	BAT	BAT	NNP
1304	1307	box	box	NN
1308	1315	binding	binding	NN
1316	1324	proteins	protein	NNS
1325	1329	were	be	VBD
1330	1335	Oct-1	oct-1	NN
1336	1339	and	and	CC
1340	1345	Oct-2	oct-2	NN
1345	1346	.	.	.

1347	1359	Southwestern	Southwestern	NNP
1360	1368	blotting	blotting	NN
1369	1372	and	and	CC
1373	1375	UV	UV	NNP
1376	1389	cross-linking	cross-linking	JJ
1390	1397	studies	study	NNS
1398	1407	confirmed	confirm	VBD
1408	1412	that	that	IN
1413	1416	the	the	DT
1417	1420	BAT	BAT	NNP
1421	1424	box	box	NN
1425	1432	binding	binding	NN
1433	1441	proteins	protein	NNS
1442	1446	were	be	VBD
1447	1452	Oct-1	oct-1	NN
1453	1456	and	and	CC
1457	1462	Oct-2	oct-2	NN
1462	1463	.	.	.

1464	1467	The	the	DT
1468	1476	affinity	affinity	NN
1477	1479	of	of	IN
1480	1483	the	the	DT
1484	1487	BAT	BAT	NNP
1488	1491	box	box	NN
1492	1499	binding	binding	NN
1500	1508	proteins	protein	NNS
1509	1512	for	for	IN
1513	1516	the	the	DT
1517	1520	BAT	BAT	NNP
1521	1524	box	box	NN
1525	1528	was	be	VBD
1529	1542	approximately	approximately	RB
1543	1550	25-fold	25-fold	RB
1551	1555	less	less	JJR
1556	1560	than	than	IN
1561	1564	for	for	IN
1565	1568	the	the	DT
1569	1576	octamer	octamer	NN
1577	1585	sequence	sequence	NN
1586	1589	and	and	CC
1590	1593	the	the	DT
1594	1597	BAT	BAT	NNP
1598	1601	box	box	NN
1602	1609	binding	binding	NN
1610	1618	proteins	protein	NNS
1619	1630	dissociated	dissociate	VBN
1631	1635	from	from	IN
1636	1639	the	the	DT
1640	1643	BAT	BAT	NNP
1644	1647	box	box	NN
1648	1655	10-fold	10-fold	RB
1656	1660	more	more	RBR
1661	1668	rapidly	rapidly	RB
1669	1673	than	than	IN
1674	1678	from	from	IN
1679	1682	the	the	DT
1683	1690	octamer	octamer	NN
1691	1699	sequence	sequence	NN
1699	1700	.	.	.

1701	1708	Despite	despite	IN
1709	1713	this	this	DT
1714	1719	lower	low	JJR
1720	1728	affinity	affinity	NN
1728	1729	,	,	,
1730	1731	a	a	DT
1732	1738	trimer	trimer	NN
1739	1741	of	of	IN
1742	1745	the	the	DT
1746	1749	BAT	BAT	NNP
1750	1753	box	box	NN
1754	1762	sequence	sequence	NN
1763	1766	was	be	VBD
1767	1769	as	as	IN
1770	1781	efficiently	efficiently	RB
1782	1796	transactivated	transactivate	VBN
1797	1799	by	by	IN
1800	1802	an	an	DT
1803	1808	Oct-2	oct-2	NN
1809	1819	expression	expression	NN
1820	1826	vector	vector	NN
1827	1829	as	as	IN
1830	1833	was	be	VBD
1834	1835	a	a	DT
1836	1842	trimer	trimer	NN
1843	1845	of	of	IN
1846	1849	the	the	DT
1850	1857	octamer	octamer	NN
1858	1866	sequence	sequence	NN
1867	1869	in	in	IN
1870	1874	HeLa	HeLa	NNP
1875	1880	cells	cell	NNS
1880	1881	.	.	.

1882	1885	The	the	DT
1886	1889	BAT	BAT	NNP
1890	1893	box	box	NN
1894	1897	and	and	CC
1898	1903	Oct-2	oct-2	NN
1904	1908	were	be	VBD
1909	1913	also	also	RB
1914	1924	implicated	implicate	VBN
1925	1927	in	in	IN
1928	1931	the	the	DT
1932	1941	induction	induction	NN
1942	1944	of	of	IN
1945	1949	CD20	CD20	NNP
1950	1952	in	in	IN
1953	1956	the	the	DT
1957	1962	pre-B	pre-b	JJ
1963	1967	cell	cell	NN
1968	1972	line	line	NN
1972	1973	,	,	,
1974	1980	PB-697	PB-697	NNP
1980	1981	,	,	,
1982	1985	via	via	IN
1986	1993	phorbol	phorbol	NN
1994	2000	esters	ester	NNS
2000	2001	.	.	.

2002	2005	The	the	DT
2006	2015	induction	induction	NN
2016	2018	of	of	IN
2019	2023	CD20	CD20	NNP
2024	2028	mRNA	mRNA	NNP
2029	2032	was	be	VBD
2033	2043	temporally	temporally	RB
2044	2054	associated	associate	VBN
2055	2059	with	with	IN
2060	2069	induction	induction	NN
2070	2072	of	of	IN
2073	2078	Oct-2	Oct-2	NNP
2079	2083	mRNA	mRNA	NNP
2084	2087	and	and	CC
2088	2089	a	a	DT
2090	2093	BAT	bat	NN
2094	2105	box-deleted	box-deleted	JJ
2106	2114	CD20-CAT	CD20-CAT	NNP
2115	2124	construct	construct	NN
2124	2125	,	,	,
2126	2128	in	in	IN
2129	2137	contrast	contrast	NN
2138	2140	to	to	TO
2141	2144	the	the	DT
2145	2149	wild	wild	JJ
2150	2154	type	type	NN
2154	2155	,	,	,
2156	2159	was	be	VBD
2160	2166	poorly	poorly	RB
2167	2174	induced	induce	VBN
2175	2177	by	by	IN
2178	2185	phorbol	phorbol	NN
2186	2192	esters	ester	NNS
2192	2193	.	.	.

2194	2202	Together	together	RB
2203	2208	these	these	DT
2209	2216	results	result	NNS
2217	2224	suggest	suggest	VBP
2225	2229	that	that	IN
2230	2233	the	the	DT
2234	2237	BAT	BAT	NNP
2238	2241	box	box	NN
2242	2249	binding	binding	NN
2250	2258	proteins	protein	NNS
2259	2262	are	be	VBP
2263	2272	important	important	JJ
2273	2275	in	in	IN
2276	2279	the	the	DT
2280	2281	B	B	NNP
2282	2286	cell	cell	NN
2287	2295	specific	specific	JJ
2296	2306	expression	expression	NN
2307	2309	of	of	IN
2310	2314	CD20	CD20	NNP
2315	2318	and	and	CC
2319	2326	perhaps	perhaps	RB
2327	2331	CD21	cd21	NN
2331	2332	.	.	.