0 14 Identification identification NN 15 18 and and CC 19 31 purification purification NN 32 34 of of IN 35 40 human human JJ 41 45 Stat Stat NNP 46 54 proteins protein NNS 55 64 activated activate VBN 65 67 in in IN 68 76 response response NN 77 79 to to TO 80 93 interleukin-2 interleukin-2 NN 93 94 . . . 96 97 A a DT 98 101 key key JJ 102 110 cytokine cytokine NN 111 118 induced induce VBN 119 125 during during IN 126 129 the the DT 130 136 immune immune JJ 137 145 response response NN 146 148 is be VBZ 149 153 IL-2 il-2 NN 153 154 . . . 155 164 Following follow VBG 165 166 T t NN 167 171 cell cell NN 172 182 activation activation NN 182 183 , , , 184 187 the the DT 188 193 genes gene NNS 194 202 encoding encode VBG 203 207 IL-2 il-2 NN 208 211 and and CC 212 215 the the DT 216 223 various various JJ 224 230 chains chain NNS 231 233 of of IN 234 237 its its PRP$ 238 246 receptor receptor NN 247 250 are be VBP 251 268 transcriptionally transcriptionally RB 269 276 induced induce VBN 276 277 . . . 278 280 In in IN 281 285 turn turn NN 285 286 , , , 287 295 secreted secrete VBN 296 300 IL-2 il-2 NN 301 307 serves serve VBZ 308 310 to to TO 311 320 stimulate stimulate VB 321 324 the the DT 325 338 proliferation proliferation NN 339 342 and and CC 343 358 differentiation differentiation NN 359 361 of of IN 362 363 T t NN 364 375 lymphocytes lymphocyte NNS 375 376 . . . 377 384 Several several JJ 385 391 recent recent JJ 392 399 studies study NNS 400 404 have have VBP 405 415 implicated implicate VBN 416 419 Jak Jak NNP 420 427 kinases kinase NNS 428 430 in in IN 431 434 the the DT 435 444 signaling signaling NN 445 452 pathway pathway NN 453 460 induced induce VBN 461 463 by by IN 464 468 IL-2 il-2 NN 468 469 . . . 470 479 Following follow VBG 480 484 this this DT 485 489 lead lead NN 489 490 , , , 491 493 we we PRP 494 497 set set VBD 498 501 out out RP 502 504 to to TO 505 513 identify identify VB 514 527 transcription transcription NN 528 535 factors factor NNS 536 543 induced induce VBN 544 546 in in IN 547 555 response response NN 556 558 to to TO 559 563 IL-2 il-2 NN 563 564 . . . 565 570 Human human JJ 571 581 peripheral peripheral JJ 582 587 blood blood NN 588 599 lymphocytes lymphocyte NNS 600 604 were be VBD 605 613 observed observe VBN 614 616 to to TO 617 624 contain contain VB 625 632 several several JJ 633 647 IL-2-inducible il-2-inducible JJ 648 651 DNA dna NN 652 659 binding binding NN 660 670 activities activity NNS 670 671 . . . 672 679 Similar similar JJ 680 690 activities activity NNS 691 695 were be VBD 696 700 also also RB 701 709 observed observe VBN 710 712 in in IN 713 714 a a DT 715 726 transformed transform VBN 727 732 human human JJ 733 743 lymphocyte lymphocyte NN 744 748 line line NN 748 749 , , , 750 756 termed term VBN 757 759 YT YT NNP 759 760 . . . 761 763 We we PRP 764 768 have have VBP 769 777 purified purify VBN 778 783 these these DT 784 794 activities activity NNS 795 798 and and CC 799 804 found find VBD 805 809 that that IN 810 813 the the DT 814 823 principal principal JJ 824 838 IL-2-inducible il-2-inducible JJ 839 848 component component NN 849 854 bears bear VBZ 855 866 significant significant JJ 867 878 relatedness relatedness NN 879 881 to to TO 882 883 a a DT 884 901 prolactin-induced prolactin-induced JJ 902 915 transcription transcription NN 916 922 factor factor NN 923 928 first first RB 929 939 identified identify VBN 940 942 in in IN 943 948 sheep sheep NN 949 956 mammary mammary JJ 957 962 gland gland NN 963 969 tissue tissue NN 969 970 . . . 971 973 We we PRP 974 985 hypothesize hypothesize VBP 986 990 that that IN 991 1001 activation activation NN 1002 1004 of of IN 1005 1009 this this DT 1010 1017 protein protein NN 1017 1018 , , , 1019 1029 designated designate VBN 1030 1036 hStat5 hstat5 NN 1036 1037 , , , 1038 1043 helps help VBZ 1044 1050 govern govern VB 1051 1054 the the DT 1055 1065 biological biological JJ 1066 1073 effects effect NNS 1074 1076 of of IN 1077 1081 IL-2 il-2 NN 1082 1088 during during IN 1089 1092 the the DT 1093 1099 immune immune JJ 1100 1108 response response NN 1108 1109 . . .