0 3 The the DT 4 8 role role NN 9 11 of of IN 12 18 shared share VBN 19 27 receptor receptor NN 28 34 motifs motif NNS 35 38 and and CC 39 45 common common JJ 46 50 Stat Stat NNP 51 59 proteins protein NNS 60 62 in in IN 63 66 the the DT 67 77 generation generation NN 78 80 of of IN 81 89 cytokine cytokine NN 90 100 pleiotropy pleiotropy NN 101 104 and and CC 105 115 redundancy redundancy NN 116 118 by by IN 119 123 IL-2 il-2 NN 123 124 , , , 125 129 IL-4 il-4 NN 129 130 , , , 131 135 IL-7 IL-7 NNP 135 136 , , , 137 142 IL-13 il-13 NN 142 143 , , , 144 147 and and CC 148 153 IL-15 IL-15 NNP 153 154 . . . 156 158 To to TO 159 169 understand understand VB 170 173 the the DT 174 183 molecular molecular JJ 184 189 bases base NNS 190 193 for for IN 194 202 cytokine cytokine NN 203 213 redundancy redundancy NN 214 217 and and CC 218 228 pleiotropy pleiotropy NN 228 229 , , , 230 232 we we PRP 233 237 have have VBP 238 246 compared compare VBN 247 250 the the DT 251 255 Stat Stat NNP 256 264 proteins protein NNS 265 274 activated activate VBN 275 277 in in IN 278 288 peripheral peripheral JJ 289 294 blood blood NN 295 306 lymphocytes lymphocyte NNS 307 308 ( ( ( 308 312 PBLs PBL NNP 312 313 ) ) ) 314 316 by by IN 317 326 cytokines cytokine NNS 327 331 with with IN 332 338 shared shared JJ 339 342 and and CC 343 351 distinct distinct JJ 352 359 actions action NNS 359 360 . . . 361 374 Interleukin-2 interleukin-2 NN 375 376 ( ( ( 376 380 IL-2 il-2 NN 380 381 ) ) ) 382 389 rapidly rapidly RB 390 399 activated activate VBD 400 405 Stat5 stat5 NN 406 408 in in IN 409 414 fresh fresh JJ 415 418 PBL PBL NNP 418 419 , , , 420 423 and and CC 424 429 Stat3 Stat3 NNP 430 433 and and CC 434 439 Stat5 Stat5 NNP 440 442 in in IN 443 455 preactivated preactivated JJ 456 459 PBL PBL NNP 459 460 . . . 461 465 IL-7 IL-7 NNP 466 469 and and CC 470 475 IL-15 IL-15 NNP 476 483 induced induce VBD 484 487 the the DT 488 492 same same JJ 493 502 complexes complex NNS 503 505 as as IN 506 510 IL-2 il-2 NN 510 511 , , , 512 513 a a DT 514 521 feature feature NN 522 531 explained explain VBN 532 534 by by IN 535 538 the the DT 539 548 existence existence NN 549 551 of of IN 552 559 similar similar JJ 560 583 tyrosine-phosphorylated tyrosine-phosphorylated JJ 584 590 motifs motif NNS 591 593 in in IN 594 597 the the DT 598 609 cytoplasmic cytoplasmic JJ 610 617 domains domain NNS 618 620 of of IN 621 626 IL-2R IL-2R NNP 627 631 beta beta NN 632 635 and and CC 636 641 IL-7R il-7r NN 642 646 that that WDT 647 650 can can MD 651 656 serve serve VB 657 659 as as IN 660 667 docking docking NN 668 673 sites site NNS 674 677 for for IN 678 682 Stat Stat NNP 683 691 proteins protein NNS 691 692 . . . 693 698 IL-13 il-13 NN 699 706 Induced induce VBD 707 710 the the DT 711 715 same same JJ 716 725 complexes complex NNS 726 728 as as IN 729 733 IL-4 il-4 NN 733 734 , , , 735 736 a a DT 737 744 finding finding NN 745 754 explained explain VBN 755 757 by by IN 758 761 our our PRP$ 762 769 studies study NNS 770 781 implicating implicate VBG 782 787 IL-4R il-4r NN 788 790 as as IN 791 792 a a DT 793 799 shared shared JJ 800 809 component component NN 810 812 of of IN 813 816 the the DT 817 826 receptors receptor NNS 826 827 . . . 828 833 These these DT 834 841 studies study NNS 842 853 demonstrate demonstrate VBP 854 858 that that IN 859 860 a a DT 861 867 single single JJ 868 876 cytokine cytokine NN 877 880 can can MD 881 889 activate activate VB 890 899 different different JJ 900 912 combinations combination NNS 913 915 of of IN 916 920 Stat Stat NNP 921 929 proteins protein NNS 930 935 under under IN 936 945 different different JJ 946 959 physiological physiological JJ 960 970 conditions condition NNS 970 971 , , , 972 975 and and CC 976 980 also also RB 981 989 indicate indicate VBP 990 993 two two CD 994 1004 mechanisms mechanism NNS 1005 1007 by by IN 1008 1013 which which WDT 1014 1022 distinct distinct JJ 1023 1032 cytokines cytokine NNS 1033 1036 can can MD 1037 1045 activate activate VB 1046 1049 the the DT 1050 1054 same same JJ 1055 1059 Stat Stat NNP 1060 1067 protein protein NN 1067 1068 . . .