0 1 A a DT 2 10 chimeric chimeric JJ 11 15 type type NN 16 23 II/type ii/type NN 24 25 I i CD 26 39 interleukin-1 interleukin-1 NN 40 48 receptor receptor NN 49 52 can can MD 53 60 mediate mediate VB 61 74 interleukin-1 interleukin-1 NN 75 84 induction induction NN 85 87 of of IN 88 92 gene gene NN 93 103 expression expression NN 104 106 in in IN 107 108 T t NN 109 114 cells cell NNS 114 115 . . . 117 120 The the DT 121 125 type type NN 126 127 I i CD 128 141 interleukin-1 interleukin-1 NN 142 150 receptor receptor NN 151 152 ( ( ( 152 157 IL-1R IL-1R NNP 157 158 ) ) ) 159 161 is be VBZ 162 169 capable capable JJ 170 172 of of IN 173 184 transducing transduce VBG 185 186 a a DT 187 193 signal signal NN 194 203 resulting result VBG 204 206 in in IN 207 215 promoter promoter NN 216 226 activation activation NN 227 229 in in IN 230 231 T t NN 232 237 cells cell NNS 237 238 . . . 239 243 This this DT 244 250 signal signal NN 251 263 transduction transduction NN 264 266 is be VBZ 267 276 dependent dependent JJ 277 279 on on IN 280 283 the the DT 284 295 cytoplasmic cytoplasmic JJ 296 302 domain domain NN 302 303 , , , 304 309 which which WDT 310 318 consists consist VBZ 319 321 of of IN 322 325 213 213 CD 326 331 amino amino NN 332 337 acids acid NNS 337 338 . . . 339 341 In in IN 342 350 contrast contrast NN 351 353 to to TO 354 357 the the DT 358 362 type type NN 363 364 I i CD 365 373 receptor receptor NN 373 374 , , , 375 378 the the DT 379 383 type type NN 384 386 II ii CD 387 392 IL-1R IL-1R NNP 393 396 has have VBZ 397 398 a a DT 399 404 small small JJ 405 416 cytoplasmic cytoplasmic JJ 417 421 tail tail NN 421 422 , , , 423 426 and and CC 427 429 it it PRP 430 432 is be VBZ 433 436 not not RB 437 442 clear clear JJ 443 450 whether whether IN 451 455 this this DT 456 464 receptor receptor NN 465 467 is be VBZ 468 469 a a DT 470 488 signal-transducing signal-transducing JJ 489 491 or or CC 492 493 a a DT 494 504 regulatory regulatory JJ 505 513 molecule molecule NN 513 514 . . . 515 519 Here here RB 520 522 we we PRP 523 529 report report VBP 530 534 that that IN 535 538 the the DT 539 543 type type NN 544 546 II ii CD 547 552 IL-1R IL-1R NNP 553 557 does do VBZ 558 561 not not RB 562 569 mediate mediate VB 570 574 gene gene NN 575 585 activation activation NN 586 588 in in IN 589 595 Jurkat Jurkat NNP 596 601 cells cell NNS 601 602 . . . 603 610 However however RB 610 611 , , , 612 613 a a DT 614 620 hybrid hybrid NN 621 629 receptor receptor NN 630 638 composed compose VBN 639 641 of of IN 642 645 the the DT 646 659 extracellular extracellular JJ 660 663 and and CC 664 677 transmembrane transmembrane NN 678 685 regions region NNS 686 688 of of IN 689 692 the the DT 693 698 human human JJ 699 703 type type NN 704 706 II ii CD 707 720 interleukin-1 interleukin-1 NN 721 726 fused fuse VBN 727 729 to to TO 730 733 the the DT 734 745 cytoplasmic cytoplasmic JJ 746 752 domain domain NN 753 755 of of IN 756 759 the the DT 760 765 human human JJ 766 770 type type NN 771 772 I i CD 773 778 IL-1R il-1r NN 779 782 was be VBD 783 790 capable capable JJ 791 793 of of IN 794 805 transducing transduce VBG 806 807 a a DT 808 814 signal signal NN 815 821 across across IN 822 825 the the DT 826 834 membrane membrane NN 835 844 resulting result VBG 845 847 in in IN 848 849 a a DT 850 857 pattern pattern NN 858 860 of of IN 861 865 gene gene NN 866 876 activation activation NN 877 886 identical identical JJ 887 889 to to TO 890 894 that that DT 895 903 mediated mediate VBN 904 906 by by IN 907 910 the the DT 911 915 type type NN 916 917 I i CD 918 923 IL-1R il-1r NN 923 924 . . . 925 928 Our our PRP$ 929 936 results result NNS 937 946 indicated indicate VBD 947 951 that that IN 952 955 the the DT 956 969 extracellular extracellular JJ 970 976 domain domain NN 977 979 of of IN 980 983 the the DT 984 988 type type NN 989 991 II ii CD 992 997 IL-1R IL-1R NNP 998 1001 was be VBD 1002 1009 capable capable JJ 1010 1012 of of IN 1013 1025 functionally functionally RB 1026 1037 interacting interact VBG 1038 1042 with with IN 1043 1056 interleukin-1 interleukin-1 NN 1057 1060 and and CC 1061 1073 transmitting transmit VBG 1074 1077 the the DT 1078 1087 resulting result VBG 1088 1094 signal signal NN 1095 1097 to to TO 1098 1099 a a DT 1100 1112 heterologous heterologous JJ 1113 1124 cytoplasmic cytoplasmic JJ 1125 1131 domain domain NN 1131 1132 . . .