0 9 Minimally minimally RB 10 18 modified modify VBN 19 22 low low JJ 23 30 density density NN 31 50 lipoprotein-induced lipoprotein-induced JJ 51 63 inflammatory inflammatory JJ 64 73 responses response NNS 74 76 in in IN 77 88 endothelial endothelial JJ 89 94 cells cell NNS 95 98 are be VBP 99 107 mediated mediate VBN 108 110 by by IN 111 117 cyclic cyclic JJ 118 127 adenosine adenosine NN 128 141 monophosphate monophosphate NN 141 142 . . . 144 146 We we PRP 147 151 have have VBP 152 162 previously previously RB 163 168 shown show VBN 169 173 that that IN 174 183 minimally minimally RB 184 192 oxidized oxidize VBN 193 196 LDL LDL NNP 197 198 ( ( ( 198 204 MM-LDL MM-LDL NNP 204 205 ) ) ) 206 215 activated activate VBD 216 227 endothelial endothelial JJ 228 233 cells cell NNS 234 236 to to TO 237 245 increase increase VB 246 251 their their PRP$ 252 263 interaction interaction NN 264 268 with with IN 269 278 monocytes monocyte NNS 279 282 but but CC 283 286 not not RB 287 298 neutrophils neutrophil NNS 298 299 , , , 300 308 inducing induce VBG 309 317 monocyte monocyte NN 318 321 but but CC 322 325 not not RB 326 336 neutrophil neutrophil NN 337 344 binding binding NN 345 348 and and CC 349 358 synthesis synthesis NN 359 361 of of IN 362 370 monocyte monocyte NN 371 382 chemotactic chemotactic JJ 383 392 protein-1 protein-1 NN 393 396 and and CC 397 405 monocyte monocyte NN 406 424 colony-stimulating colony-stimulating JJ 425 431 factor factor NN 432 433 ( ( ( 433 438 M-CSF M-CSF NNP 438 439 ) ) ) 439 440 . . . 441 443 In in IN 444 447 the the DT 448 455 present present JJ 456 463 studies study NNS 464 466 we we PRP 467 471 have have VBP 472 480 examined examine VBN 481 484 the the DT 485 494 signaling signaling NN 495 503 pathways pathway NNS 504 506 by by IN 507 512 which which WDT 513 517 this this DT 518 535 monocyte-specific monocyte-specific JJ 536 544 response response NN 545 547 is be VBZ 548 555 induced induce VBN 555 556 . . . 557 561 Both both CC 562 571 induction induction NN 572 574 of of IN 575 583 monocyte monocyte NN 584 591 binding binding NN 592 595 and and CC 596 600 mRNA mrna NN 601 607 levels level NNS 608 611 for for IN 612 617 M-CSF M-CSF NNP 618 620 by by IN 621 627 MM-LDL MM-LDL NNP 628 632 were be VBD 633 636 not not RB 637 646 inhibited inhibit VBN 647 649 in in IN 650 657 protein protein NN 658 664 kinase kinase NNP 665 675 C-depleted c-depleted JJ 676 687 endothelial endothelial JJ 688 693 cells cell NNS 693 694 . . . 695 696 A a DT 697 703 number number NN 704 706 of of IN 707 710 our our PRP$ 711 718 studies study NNS 719 727 indicate indicate VBP 728 732 that that IN 733 737 cAMP camp NN 738 740 is be VBZ 741 744 the the DT 745 751 second second JJ 752 761 messenger messenger NN 762 765 for for IN 766 769 the the DT 770 777 effects effect NNS 778 780 of of IN 781 787 MM-LDL MM-LDL NNP 788 793 cited cite VBD 794 799 above above RB 799 800 . . . 801 811 Incubation incubation NN 812 814 of of IN 815 826 endothelial endothelial JJ 827 832 cells cell NNS 833 837 with with IN 838 844 MM-LDL MM-LDL NNP 845 851 caused cause VBD 852 853 a a DT 854 857 173 173 CD 857 858 % % NN 859 867 increase increase NN 868 870 in in IN 871 884 intracellular intracellular JJ 885 889 cAMP camp NN 890 896 levels level NNS 896 897 . . . 898 904 Agents agent NNS 905 910 which which WDT 911 920 increased increase VBD 921 925 cAMP camp NN 926 932 levels level NNS 932 933 , , , 934 943 including include VBG 944 951 cholera cholera NN 952 957 toxin toxin NN 957 958 , , , 959 968 pertussis pertussis NN 969 974 toxin toxin NN 974 975 , , , 976 985 dibutyryl dibutyryl NN 986 990 cAMP camp NN 990 991 , , , 992 995 and and CC 996 1009 isoproterenol isoproterenol NN 1010 1018 mimicked mimic VBD 1019 1022 the the DT 1023 1030 actions action NNS 1031 1033 of of IN 1034 1040 MM-LDL MM-LDL NNP 1040 1041 . . . 1042 1048 Agents agent NNS 1049 1054 which which WDT 1055 1063 elevated elevate VBD 1064 1068 cAMP camp NN 1069 1073 were be VBD 1074 1078 also also RB 1079 1084 shown show VBN 1085 1087 to to TO 1088 1096 activate activate VB 1097 1099 NF NF NNP 1100 1105 kappa kappa NN 1106 1107 B B NNP 1107 1108 , , , 1109 1119 suggesting suggest VBG 1120 1121 a a DT 1122 1126 role role NN 1127 1130 for for IN 1131 1135 this this DT 1136 1149 transcription transcription NN 1150 1156 factor factor NN 1157 1159 in in IN 1160 1170 activation activation NN 1171 1173 of of IN 1174 1194 monocyte-endothelial monocyte-endothelial JJ 1195 1207 interactions interaction NNS 1207 1208 . . . 1209 1217 Although although IN 1218 1229 endothelial endothelial JJ 1230 1239 leukocyte leukocyte NN 1240 1248 adhesion adhesion NN 1249 1257 molecule molecule NN 1258 1259 ( ( ( 1259 1263 ELAM ELAM NNP 1263 1264 ) ) ) 1265 1269 mRNA mrna NN 1270 1279 synthesis synthesis NN 1280 1283 can can MD 1284 1286 be be VB 1287 1296 regulated regulate VBN 1297 1299 by by IN 1300 1302 NF NF NNP 1303 1308 kappa kappa NN 1309 1310 B B NNP 1310 1311 , , , 1312 1316 ELAM ELAM NNP 1317 1320 was be VBD 1321 1324 not not RB 1325 1334 expressed express VBN 1335 1338 and and CC 1339 1343 ELAM ELAM NNP 1344 1348 mRNA mRNA NNP 1349 1352 was be VBD 1353 1357 only only RB 1358 1366 slightly slightly RB 1367 1375 elevated elevated JJ 1376 1378 in in IN 1379 1387 response response NN 1388 1390 to to TO 1391 1397 MM-LDL MM-LDL NNP 1397 1398 . . . 1399 1401 We we PRP 1402 1409 present present VBP 1410 1418 evidence evidence NN 1419 1423 that that IN 1424 1433 induction induction NN 1434 1436 of of IN 1437 1447 neutrophil neutrophil NN 1448 1455 binding binding NN 1456 1458 by by IN 1459 1462 LPS LPS NNP 1463 1465 is be VBZ 1466 1474 actually actually RB 1475 1485 suppressed suppress VBN 1486 1488 by by IN 1489 1495 agents agent NNS 1496 1500 that that WDT 1501 1509 elevated elevate VBD 1510 1514 cAMP camp NN 1515 1521 levels level NNS 1521 1522 . . .