0 4 p105 p105 NN 5 8 and and CC 9 12 p98 p98 NN 13 22 precursor precursor NN 23 31 proteins protein NNS 32 36 play play VBP 37 39 an an DT 40 46 active active JJ 47 51 role role NN 52 54 in in IN 55 63 NF-kappa NF-kappa NNP 64 74 B-mediated b-mediated JJ 75 81 signal signal NN 82 94 transduction transduction NN 94 95 . . . 97 100 The the DT 101 113 Rel/NF-kappa Rel/NF-kappa NNP 114 115 B B NNP 116 122 family family NN 123 125 of of IN 126 139 transcription transcription NN 140 147 factors factor NNS 148 150 is be VBZ 151 159 composed compose VBN 160 162 of of IN 163 166 two two CD 167 175 distinct distinct JJ 176 185 subgroups subgroup NNS 185 186 , , , 187 195 proteins protein NNS 196 200 that that WDT 201 208 undergo undergo VBP 209 220 proteolytic proteolytic JJ 221 231 processing processing NN 232 235 and and CC 236 243 contain contain VBP 244 256 SWI6/ankyrin SWI6/ankyrin NNP 257 264 repeats repeat NNS 265 267 in in IN 268 273 their their PRP$ 274 282 carboxyl carboxyl NN 283 290 termini terminus NNS 291 292 ( ( ( 292 296 p105 p105 NN 296 297 , , , 298 301 p98 p98 NN 301 302 ) ) ) 302 303 , , , 304 307 and and CC 308 313 those those DT 314 321 without without IN 322 326 such such JJ 327 334 repeats repeat NNS 335 339 that that WDT 340 342 do do VBP 343 346 not not RB 347 354 require require VB 355 365 processing processing NN 366 367 ( ( ( 367 370 p65 p65 NN 370 371 , , , 372 377 c-Rel c-rel NN 377 378 , , , 379 383 RelB RelB NNP 383 384 , , , 385 388 and and CC 389 395 Dorsal Dorsal NNP 395 396 ) ) ) 396 397 . . . 398 400 We we PRP 401 412 demonstrate demonstrate VBP 413 417 that that IN 418 421 the the DT 422 426 p105 p105 NN 427 430 and and CC 431 434 p98 p98 NN 435 445 precursors precursor NNS 446 451 share share VBP 452 462 functional functional JJ 463 473 properties property NNS 474 478 with with IN 479 482 the the DT 483 484 I i NN 485 490 kappa kappa NN 491 492 B B NNP 493 501 proteins protein NNS 501 502 , , , 503 508 which which WDT 509 513 also also RB 514 521 contain contain VBP 522 534 SWI6/ankyrin SWI6/ankyrin NNP 535 542 repeats repeat NNS 542 543 . . . 544 548 Both both CC 549 553 p105 p105 NN 554 557 and and CC 558 561 p98 p98 NN 562 566 were be VBD 567 572 found find VBN 573 575 to to TO 576 580 form form VB 581 587 stable stable JJ 588 597 complexes complex NNS 598 602 with with IN 603 608 other other JJ 609 621 Rel/NF-kappa Rel/NF-kappa NNP 622 623 B B NNP 624 630 family family NN 631 638 members member NNS 638 639 , , , 640 649 including include VBG 650 653 p65 p65 NN 654 657 and and CC 658 663 c-Rel c-rel NN 663 664 . . . 665 676 Association Association NNP 677 681 with with IN 682 685 the the DT 686 696 precursors precursor NNS 697 699 is be VBZ 700 710 sufficient sufficient JJ 711 714 for for IN 715 726 cytoplasmic cytoplasmic JJ 727 736 retention retention NN 737 739 of of IN 740 746 either either CC 747 750 p65 p65 NN 751 753 or or CC 754 759 c-Rel c-rel NN 759 760 , , , 761 765 both both DT 766 768 of of IN 769 774 which which WDT 775 778 are be VBP 779 788 otherwise otherwise RB 789 796 nuclear nuclear JJ 796 797 . . . 798 803 These these DT 804 813 complexes complex NNS 814 821 undergo undergo VBP 822 841 stimulus-responsive stimulus-responsive JJ 842 852 processing processing NN 853 855 to to TO 856 863 produce produce VB 864 870 active active JJ 871 880 p50/c-Rel p50/c-rel NN 881 884 and and CC 885 894 p55/c-Rel p55/c-rel NN 895 904 complexes complex NNS 904 905 . . . 906 911 These these DT 912 924 observations observation NNS 925 932 suggest suggest VBP 933 934 a a DT 935 941 second second JJ 942 949 pathway pathway NN 950 957 leading lead VBG 958 960 to to TO 961 969 NF-kappa NF-kappa NNP 970 971 B B NNP 972 981 induction induction NN 981 982 , , , 983 985 in in IN 986 991 which which WDT 992 1002 processing processing NN 1003 1005 of of IN 1006 1009 the the DT 1010 1020 precursors precursor NNS 1021 1027 rather rather RB 1028 1032 than than IN 1033 1048 phosphorylation phosphorylation NN 1049 1051 of of IN 1052 1053 I i NN 1054 1059 kappa kappa NN 1060 1061 B B NNP 1062 1067 plays play VBZ 1068 1069 a a DT 1070 1075 major major JJ 1076 1080 role role NN 1080 1081 . . .