0	18	Lipopolysaccharide	Lipopolysaccharide	NNP
19	26	induces	induce	VBZ
27	42	phosphorylation	phosphorylation	NN
43	45	of	of	IN
46	50	MAD3	mad3	NN
51	54	and	and	CC
55	65	activation	activation	NN
66	68	of	of	IN
69	74	c-Rel	c-rel	NN
75	78	and	and	CC
79	86	related	related	JJ
87	95	NF-kappa	NF-kappa	NNP
96	97	B	B	NNP
98	106	proteins	protein	NNS
107	109	in	in	IN
110	115	human	human	JJ
116	125	monocytic	monocytic	JJ
126	131	THP-1	thp-1	NN
132	137	cells	cell	NNS
137	138	.	.	.

140	144	Many	many	JJ
145	152	effects	effect	NNS
153	155	of	of	IN
156	174	lipopolysaccharide	lipopolysaccharide	NN
175	176	(	(	(
176	179	LPS	LPS	NNP
179	180	)	)	)
181	183	on	on	IN
184	188	gene	gene	NN
189	199	expression	expression	NN
199	200	,	,	,
201	210	including	include	VBG
211	215	that	that	DT
216	218	of	of	IN
219	224	human	human	JJ
225	241	immunodeficiency	immunodeficiency	NN
242	247	virus	virus	NN
248	249	(	(	(
249	252	HIV	HIV	NNP
252	253	)	)	)
253	254	,	,	,
255	257	in	in	IN
258	267	monocytic	monocytic	JJ
268	273	cells	cell	NNS
274	277	are	be	VBP
278	286	mediated	mediate	VBN
287	289	by	by	IN
290	300	activation	activation	NN
301	303	of	of	IN
304	309	kappa	kappa	NN
310	311	B	B	NNP
312	323	DNA-binding	dna-binding	JJ
324	332	proteins	protein	NNS
332	333	.	.	.

334	341	However	however	RB
341	342	,	,	,
343	346	the	the	DT
347	355	specific	specific	JJ
356	363	members	member	NNS
364	366	of	of	IN
367	370	the	the	DT
371	379	NF-kappa	NF-kappa	NNP
380	385	B/Rel	B/Rel	NNP
386	399	transcription	transcription	NN
400	406	factor	factor	NN
407	413	family	family	NN
414	422	involved	involve	VBN
423	425	in	in	IN
426	429	the	the	DT
430	433	LPS	LPS	NNP
434	442	response	response	NN
442	443	,	,	,
444	447	and	and	CC
448	451	the	the	DT
452	462	mechanisms	mechanism	NNS
463	470	through	through	IN
471	476	which	which	WDT
477	490	LPS-generated	lps-generated	JJ
491	498	signals	signal	NNS
499	502	are	be	VBP
503	513	transduced	transduce	VBN
514	520	remain	remain	VBP
521	528	unclear	unclear	JJ
528	529	.	.	.

530	534	Here	here	RB
535	537	we	we	PRP
538	542	show	show	VBP
543	547	that	that	IN
548	551	LPS	LPS	NNP
552	559	induces	induce	VBZ
560	567	nuclear	nuclear	JJ
568	578	expression	expression	NN
579	581	of	of	IN
582	591	c-Rel/p50	c-rel/p50	NN
592	604	heterodimers	heterodimer	NNS
605	607	as	as	RB
608	612	well	well	RB
613	615	as	as	IN
616	623	p50/p65	p50/p65	NN
624	625	(	(	(
625	633	NF-kappa	NF-kappa	NNP
634	635	B	B	NNP
635	636	)	)	)
637	642	kappa	kappa	NN
643	644	B	B	NNP
645	656	DNA-binding	dna-binding	JJ
657	666	complexes	complex	NNS
667	669	in	in	IN
670	675	human	human	JJ
676	685	monocytic	monocytic	JJ
686	691	THP-1	thp-1	NN
692	697	cells	cell	NNS
697	698	.	.	.

699	706	Nuclear	nuclear	JJ
707	719	localization	localization	NN
720	722	of	of	IN
723	728	these	these	DT
729	737	proteins	protein	NNS
738	746	occurred	occur	VBD
747	760	concomitantly	concomitantly	RB
761	765	with	with	IN
766	767	a	a	DT
768	773	rapid	rapid	JJ
774	782	decrease	decrease	NN
783	785	in	in	IN
786	791	their	their	PRP$
792	801	cytosolic	cytosolic	JJ
802	808	levels	level	NNS
809	812	and	and	CC
813	816	was	be	VBD
817	828	independent	independent	JJ
829	831	of	of	IN
832	839	phorbol	phorbol	NN
840	855	ester-sensitive	ester-sensitive	JJ
856	863	protein	protein	NN
864	870	kinase	kinase	NNP
871	873	C.	C.	NNP
874	880	Within	within	IN
881	883	24	24	CD
884	885	h	h	NN
886	895	following	follow	VBG
896	899	LPS	LPS	NNP
900	911	stimulation	stimulation	NN
912	917	there	there	EX
918	921	was	be	VBD
922	923	a	a	DT
924	932	striking	striking	JJ
933	941	increase	increase	NN
942	944	in	in	IN
945	948	the	the	DT
949	955	levels	level	NNS
956	958	of	of	IN
959	964	c-Rel	c-rel	NN
964	965	,	,	,
966	970	p105	p105	NN
970	971	,	,	,
972	975	and	and	CC
976	979	p50	p50	NN
980	982	in	in	IN
983	986	the	the	DT
987	994	cytosol	cytosol	NN
994	995	.	.	.

996	999	The	the	DT
1000	1009	increased	increase	VBN
1010	1016	levels	level	NNS
1017	1019	of	of	IN
1020	1025	these	these	DT
1026	1034	proteins	protein	NNS
1035	1045	correlated	correlate	VBD
1046	1050	with	with	IN
1051	1060	increases	increase	NNS
1061	1063	in	in	IN
1064	1067	the	the	DT
1068	1075	amounts	amount	NNS
1076	1078	of	of	IN
1079	1084	their	their	PRP$
1085	1090	mRNAs	mrna	NNS
1091	1097	during	during	IN
1098	1101	LPS	LPS	NNP
1102	1112	activation	activation	NN
1113	1115	of	of	IN
1116	1121	THP-1	thp-1	NN
1122	1127	cells	cell	NNS
1127	1128	.	.	.

1129	1132	LPS	LPS	NNP
1133	1143	activation	activation	NN
1144	1146	of	of	IN
1147	1152	THP-1	thp-1	NN
1153	1158	cells	cell	NNS
1159	1167	resulted	result	VBD
1168	1170	in	in	IN
1171	1186	phosphorylation	phosphorylation	NN
1187	1189	of	of	IN
1190	1194	MAD3	MAD3	NNP
1195	1196	(	(	(
1196	1198	an	an	DT
1199	1200	I	i	NN
1201	1206	kappa	kappa	NN
1207	1213	B-like	b-like	JJ
1214	1221	protein	protein	NN
1221	1222	)	)	)
1222	1223	,	,	,
1224	1225	a	a	DT
1226	1231	rapid	rapid	JJ
1232	1240	increase	increase	NN
1241	1243	in	in	IN
1244	1248	MAD3	MAD3	NNP
1249	1253	mRNA	mRNA	NNP
1253	1254	,	,	,
1255	1258	and	and	CC
1259	1261	an	an	DT
1262	1270	increase	increase	NN
1271	1273	in	in	IN
1274	1278	MAD3	mad3	NN
1279	1286	protein	protein	NN
1287	1289	by	by	IN
1290	1291	2	2	CD
1292	1293	h	h	NN
1293	1294	.	.	.

1295	1299	Thus	thus	RB
1299	1300	,	,	,
1301	1304	LPS	LPS	NNP
1305	1315	activation	activation	NN
1316	1318	of	of	IN
1319	1324	human	human	JJ
1325	1334	monocytic	monocytic	JJ
1335	1340	cells	cell	NNS
1341	1348	results	result	VBZ
1349	1351	in	in	IN
1352	1359	nuclear	nuclear	JJ
1360	1370	expression	expression	NN
1371	1373	of	of	IN
1374	1383	c-Rel/p50	c-rel/p50	NN
1384	1387	and	and	CC
1388	1395	p50/p65	p50/p65	NN
1396	1397	(	(	(
1397	1405	NF-kappa	NF-kappa	NNP
1406	1407	B	B	NNP
1407	1408	)	)	)
1409	1412	and	and	CC
1413	1420	induces	induce	VBZ
1421	1436	phosphorylation	phosphorylation	NN
1437	1439	of	of	IN
1440	1444	MAD3	MAD3	NNP
1444	1445	.	.	.