0	15	Transcriptional	transcriptional	JJ
16	26	activation	activation	NN
27	29	of	of	IN
30	33	the	the	DT
34	44	macrophage	macrophage	NN
45	63	colony-stimulating	colony-stimulating	JJ
64	70	factor	factor	NN
71	75	gene	gene	NN
76	78	by	by	IN
79	83	IL-2	il-2	NN
84	86	is	be	VBZ
87	97	associated	associate	VBN
98	102	with	with	IN
103	112	secretion	secretion	NN
113	115	of	of	IN
116	125	bioactive	bioactive	JJ
126	136	macrophage	macrophage	NN
137	155	colony-stimulating	colony-stimulating	JJ
156	162	factor	factor	NN
163	170	protein	protein	NN
171	173	by	by	IN
174	183	monocytes	monocyte	NNS
184	187	and	and	CC
188	196	involves	involve	VBZ
197	207	activation	activation	NN
208	210	of	of	IN
211	214	the	the	DT
215	228	transcription	transcription	NN
229	235	factor	factor	NN
236	244	NF-kappa	NF-kappa	NNP
245	247	B.	B.	NNP
249	254	Human	human	JJ
255	265	peripheral	peripheral	JJ
266	271	blood	blood	NN
272	281	monocytes	monocyte	NNS
282	283	(	(	(
283	285	Mo	Mo	NNP
285	286	)	)	)
287	301	constitutively	constitutively	RB
302	309	display	display	VBP
310	313	the	the	DT
314	324	beta-chain	beta-chain	NN
325	327	of	of	IN
328	331	the	the	DT
332	340	receptor	receptor	NN
341	344	for	for	IN
345	349	IL-2	il-2	NN
349	350	,	,	,
351	358	whereas	whereas	IN
359	369	expression	expression	NN
370	372	of	of	IN
373	376	the	the	DT
377	382	IL-2R	IL-2R	NNP
383	394	alpha-chain	alpha-chain	NN
395	397	is	be	VBZ
398	401	not	not	RB
402	414	constitutive	constitutive	JJ
415	418	but	but	CC
419	428	inducible	inducible	JJ
429	433	with	with	IN
434	438	IL-2	il-2	NN
438	439	.	.	.

440	444	Here	here	RB
445	447	we	we	PRP
448	454	report	report	VBP
455	459	that	that	IN
460	467	binding	binding	NN
468	470	of	of	IN
471	476	human	human	JJ
477	481	IL-2	il-2	NN
482	484	to	to	TO
485	488	its	its	PRP$
489	496	binding	bind	VBG
497	501	site	site	NN
502	507	leads	lead	VBZ
508	510	to	to	TO
511	526	transcriptional	transcriptional	JJ
527	537	activation	activation	NN
538	540	of	of	IN
541	544	the	the	DT
545	555	macrophage	macrophage	NN
556	559	CSF	CSF	NNP
560	561	(	(	(
561	566	M-CSF	M-CSF	NNP
566	567	)	)	)
568	572	gene	gene	NN
573	575	in	in	IN
576	578	Mo	Mo	NNP
579	588	resulting	result	VBG
589	591	in	in	IN
592	604	accumulation	accumulation	NN
605	607	of	of	IN
608	613	M-CSF	M-CSF	NNP
614	618	mRNA	mRNA	NNP
619	622	and	and	CC
623	633	subsequent	subsequent	JJ
634	641	release	release	NN
642	644	of	of	IN
645	654	bioactive	bioactive	JJ
655	660	M-CSF	M-CSF	NNP
661	668	protein	protein	NN
669	671	as	as	IN
672	684	demonstrated	demonstrate	VBN
685	687	by	by	IN
688	693	ELISA	ELISA	NNP
694	697	and	and	CC
698	708	inhibition	inhibition	NN
709	711	of	of	IN
712	716	IL-2	il-2	NN
717	724	induced	induce	VBD
725	732	release	release	NN
733	735	of	of	IN
736	738	an	an	DT
739	759	activity-stimulating	activity-stimulating	JJ
760	766	growth	growth	NN
767	769	of	of	IN
770	783	monocyte-type	monocyte-type	JJ
784	792	colonies	colony	NNS
793	795	by	by	IN
796	797	a	a	DT
798	810	neutralizing	neutralize	VBG
811	821	anti-M-CSF	anti-m-csf	JJ
822	830	antibody	antibody	NN
830	831	.	.	.

832	847	Transcriptional	transcriptional	JJ
848	858	activation	activation	NN
859	861	of	of	IN
862	865	the	the	DT
866	871	M-CSF	M-CSF	NNP
872	876	gene	gene	NN
877	879	by	by	IN
880	884	IL-2	il-2	NN
885	887	is	be	VBZ
888	896	preceded	precede	VBN
897	899	by	by	IN
900	908	enhanced	enhance	VBN
909	916	binding	binding	NN
917	925	activity	activity	NN
926	928	of	of	IN
929	932	the	the	DT
933	946	transcription	transcription	NN
947	953	factor	factor	NN
954	962	NF-kappa	NF-kappa	NNP
963	964	B	B	NNP
965	967	to	to	TO
968	971	its	its	PRP$
972	983	recognition	recognition	NN
984	992	sequence	sequence	NN
993	995	in	in	IN
996	999	the	the	DT
1000	1001	5	5	CD
1001	1002	’	'	SYM
1003	1013	regulatory	regulatory	JJ
1014	1022	enhancer	enhancer	NN
1023	1029	region	region	NN
1030	1032	of	of	IN
1033	1036	the	the	DT
1037	1042	M-CSF	M-CSF	NNP
1043	1047	gene	gene	NN
1047	1048	.	.	.

1049	1057	Moreover	moreover	RB
1057	1058	,	,	,
1059	1064	using	use	VBG
1065	1066	a	a	DT
1067	1079	heterologous	heterologous	JJ
1080	1088	promoter	promoter	NN
1089	1090	(	(	(
1090	1096	herpes	herpes	NN
1097	1106	thymidine	thymidine	NN
1107	1113	kinase	kinase	NNP
1113	1114	)	)	)
1115	1124	construct	construct	NN
1125	1135	containing	contain	VBG
1136	1139	the	the	DT
1140	1148	NF-kappa	NF-kappa	NNP
1149	1150	B	B	NNP
1151	1160	consensus	consensus	NN
1161	1169	sequence	sequence	NN
1169	1170	,	,	,
1171	1173	it	it	PRP
1174	1176	is	be	VBZ
1177	1182	shown	show	VBN
1183	1187	that	that	IN
1188	1196	NF-kappa	NF-kappa	NNP
1197	1198	B	B	NNP
1199	1206	binding	binding	NN
1207	1209	by	by	IN
1210	1212	an	an	DT
1213	1225	IL-2-induced	il-2-induced	JJ
1226	1242	monocyte-derived	monocyte-derived	JJ
1243	1250	nuclear	nuclear	JJ
1251	1258	protein	protein	NN
1259	1266	confers	confer	VBZ
1267	1275	reporter	reporter	NN
1276	1280	gene	gene	NN
1281	1282	(	(	(
1282	1287	human	human	JJ
1288	1294	growth	growth	NN
1295	1302	hormone	hormone	NN
1302	1303	)	)	)
1304	1312	activity	activity	NN
1312	1313	.	.	.

1314	1319	Taken	take	VBN
1320	1328	together	together	RB
1328	1329	,	,	,
1330	1333	our	our	PRP$
1334	1342	findings	finding	NNS
1343	1351	indicate	indicate	VBP
1352	1356	that	that	IN
1357	1361	IL-2	il-2	NN
1362	1369	induces	induce	VBZ
1370	1374	gene	gene	NN
1375	1385	expression	expression	NN
1386	1388	of	of	IN
1389	1394	M-CSF	M-CSF	NNP
1395	1397	in	in	IN
1398	1403	human	human	JJ
1404	1417	blood-derived	blood-derived	JJ
1418	1420	Mo	Mo	NNP
1421	1424	and	and	CC
1425	1432	provide	provide	VBP
1433	1441	evidence	evidence	NN
1442	1445	for	for	IN
1446	1457	involvement	involvement	NN
1458	1460	of	of	IN
1461	1469	NF-kappa	NF-kappa	NNP
1470	1471	B	B	NNP
1472	1474	in	in	IN
1475	1490	transcriptional	transcriptional	JJ
1491	1501	regulation	regulation	NN
1502	1504	of	of	IN
1505	1509	this	this	DT
1510	1514	gene	gene	NN
1514	1515	.	.	.