0	7	Effects	Effect	NNPS
8	10	of	of	IN
11	16	IL-10	IL-10	NNP
17	20	and	and	CC
21	25	IL-4	il-4	NN
26	28	on	on	IN
29	40	LPS-induced	lps-induced	JJ
41	54	transcription	transcription	NN
55	62	factors	factor	NNS
63	64	(	(	(
64	68	AP-1	AP-1	NNP
68	69	,	,	,
70	76	NF-IL6	NF-IL6	NNP
77	80	and	and	CC
81	89	NF-kappa	NF-kappa	NNP
90	91	B	B	NNP
91	92	)	)	)
93	98	which	which	WDT
99	102	are	be	VBP
103	111	involved	involve	VBN
112	114	in	in	IN
115	119	IL-6	IL-6	NNP
120	130	regulation	regulation	NN
130	131	.	.	.

133	147	Interleukin-10	Interleukin-10	NNP
148	149	(	(	(
149	154	IL-10	IL-10	NNP
154	155	)	)	)
155	156	,	,	,
157	161	like	like	IN
162	166	IL-4	il-4	NN
166	167	,	,	,
168	170	is	be	VBZ
171	176	known	know	VBN
177	179	to	to	TO
180	187	inhibit	inhibit	VB
188	196	cytokine	cytokine	NN
197	207	expression	expression	NN
208	210	in	in	IN
211	220	activated	activate	VBN
221	226	human	human	JJ
227	236	monocytes	monocyte	NNS
236	237	.	.	.

238	240	We	we	PRP
241	247	showed	show	VBD
248	252	that	that	IN
253	257	both	both	CC
258	263	IL-10	il-10	NN
264	267	and	and	CC
268	272	IL-4	il-4	NN
273	280	inhibit	inhibit	VBP
281	292	LPS-induced	lps-induced	JJ
293	297	IL-6	IL-6	NNP
298	302	mRNA	mRNA	NNP
303	306	and	and	CC
307	314	protein	protein	NN
315	325	expression	expression	NN
326	328	by	by	IN
329	339	inhibiting	inhibit	VBG
340	343	the	the	DT
344	357	transcription	transcription	NN
358	362	rate	rate	NN
363	365	of	of	IN
366	369	the	the	DT
370	374	IL-6	il-6	NN
375	379	gene	gene	NN
379	380	.	.	.

381	384	The	the	DT
385	391	strong	strong	JJ
392	402	inhibition	inhibition	NN
403	405	of	of	IN
406	409	the	the	DT
410	414	IL-6	IL-6	NNP
415	428	transcription	transcription	NN
429	433	rate	rate	NN
434	442	prompted	prompt	VBD
443	445	us	us	PRP
446	448	to	to	TO
449	454	study	study	VB
455	458	the	the	DT
459	465	effect	effect	NN
466	468	of	of	IN
469	474	IL-10	il-10	NN
475	478	and	and	CC
479	483	IL-4	il-4	NN
484	486	on	on	IN
487	490	the	the	DT
491	501	expression	expression	NN
502	504	of	of	IN
505	518	transcription	transcription	NN
519	526	factors	factor	NNS
526	527	.	.	.

528	530	We	we	PRP
531	541	questioned	question	VBD
542	549	whether	whether	IN
550	552	or	or	CC
553	556	not	not	RB
557	562	IL-10	il-10	NN
563	566	and	and	CC
567	571	IL-4	il-4	NN
572	580	affected	affect	VBD
581	584	the	the	DT
585	595	expression	expression	NN
596	598	of	of	IN
599	612	transcription	transcription	NN
613	620	factors	factor	NNS
621	625	that	that	WDT
626	629	are	be	VBP
630	635	known	know	VBN
636	638	to	to	TO
639	641	be	be	VB
642	650	involved	involve	VBN
651	653	in	in	IN
654	657	the	the	DT
658	665	control	control	NN
666	668	of	of	IN
669	672	the	the	DT
673	677	IL-6	IL-6	NNP
678	691	transcription	transcription	NN
692	696	rate	rate	NN
696	697	,	,	,
698	704	namely	namely	RB
705	714	activator	activator	NN
715	724	protein-1	protein-1	NN
725	726	(	(	(
726	730	AP-1	ap-1	NN
730	731	)	)	)
731	732	,	,	,
733	740	nuclear	nuclear	JJ
741	747	factor	factor	NN
748	752	IL-6	IL-6	NNP
753	754	(	(	(
754	760	NF-IL6	NF-IL6	NNP
760	761	)	)	)
761	762	,	,	,
763	766	and	and	CC
767	774	nuclear	nuclear	JJ
775	781	factor	factor	NN
782	787	kappa	kappa	NN
788	789	B	B	NNP
790	791	(	(	(
791	800	NF-kappaB	NF-kappaB	NNP
800	801	)	)	)
801	802	.	.	.

803	805	In	in	IN
806	821	electrophoretic	electrophoretic	JJ
822	830	mobility	mobility	NN
831	836	shift	shift	NN
837	843	assays	assay	NNS
844	845	(	(	(
845	850	EMSAs	EMSA	NNP
850	851	)	)	)
852	854	we	we	PRP
855	861	showed	show	VBD
862	866	that	that	IN
867	872	IL-10	il-10	NN
873	876	and	and	CC
877	881	IL-4	il-4	NN
882	891	inhibited	inhibit	VBD
892	903	LPS-induced	lps-induced	JJ
904	908	AP-1	ap-1	NN
909	916	binding	binding	NN
917	925	activity	activity	NN
925	926	.	.	.

927	930	The	the	DT
931	941	inhibiting	inhibit	VBG
942	948	effect	effect	NN
949	951	of	of	IN
952	956	IL-4	il-4	NN
957	960	was	be	VBD
961	969	slightly	slightly	RB
970	974	more	more	RBR
975	985	pronounced	pronounced	JJ
986	990	than	than	IN
991	995	that	that	DT
996	998	of	of	IN
999	1004	IL-10	IL-10	NNP
1004	1005	.	.	.

1006	1020	Downregulation	downregulation	NN
1021	1023	of	of	IN
1024	1035	LPS-induced	lps-induced	JJ
1036	1040	AP-1	ap-1	NN
1041	1044	was	be	VBD
1045	1056	accompanied	accompany	VBN
1056	1057	,	,	,
1058	1061	and	and	CC
1062	1066	thus	thus	RB
1067	1075	possibly	possibly	RB
1076	1085	explained	explain	VBN
1085	1086	,	,	,
1087	1089	by	by	IN
1090	1091	a	a	DT
1092	1099	reduced	reduce	VBN
1100	1110	expression	expression	NN
1111	1113	at	at	IN
1114	1118	mRNA	mrna	NN
1119	1124	level	level	NN
1125	1127	of	of	IN
1128	1131	the	the	DT
1132	1135	two	two	CD
1136	1141	major	major	JJ
1142	1152	components	component	NNS
1153	1155	of	of	IN
1156	1159	the	the	DT
1160	1164	AP-1	ap-1	NN
1165	1172	complex	complex	NN
1172	1173	,	,	,
1174	1180	namely	namely	RB
1181	1186	c-fos	c-fos	NN
1187	1190	and	and	CC
1191	1196	c-jun	c-jun	NN
1197	1199	as	as	IN
1200	1210	determined	determine	VBN
1211	1213	by	by	IN
1214	1222	Northern	northern	NN
1223	1234	experiments	experiment	NNS
1234	1235	.	.	.

1236	1243	Binding	binding	NN
1244	1252	activity	activity	NN
1253	1255	of	of	IN
1256	1262	NF-IL6	NF-IL6	NNP
1263	1266	was	be	VBD
1267	1271	also	also	RB
1272	1280	strongly	strongly	RB
1281	1290	inhibited	inhibit	VBN
1291	1293	by	by	IN
1294	1298	IL-4	il-4	NN
1299	1306	whereas	whereas	IN
1307	1312	IL-10	IL-10	NNP
1313	1319	showed	show	VBD
1320	1322	no	no	DT
1323	1329	effect	effect	NN
1329	1330	.	.	.

1331	1337	NF-IL6	NF-IL6	NNP
1338	1342	mRNA	mRNA	NNP
1343	1349	levels	level	NNS
1350	1354	were	be	VBD
1355	1358	not	not	RB
1359	1367	affected	affect	VBN
1368	1370	by	by	IN
1371	1376	IL-10	il-10	NN
1377	1379	or	or	CC
1380	1384	IL-4	il-4	NN
1384	1385	,	,	,
1386	1396	suggesting	suggest	VBG
1397	1401	that	that	IN
1402	1406	IL-4	il-4	NN
1407	1414	affects	affect	VBZ
1415	1422	binding	binding	NN
1423	1431	activity	activity	NN
1432	1434	of	of	IN
1435	1446	preexisting	preexist	VBG
1447	1453	NF-IL6	nf-il6	NN
1453	1454	.	.	.

1455	1462	Neither	neither	CC
1463	1468	IL-10	il-10	NN
1469	1472	nor	nor	CC
1473	1477	IL-4	il-4	NN
1478	1487	inhibited	inhibit	VBD
1488	1499	LPS-induced	lps-induced	JJ
1500	1508	NF-kappa	NF-kappa	NNP
1509	1510	B	B	NNP
1511	1518	binding	binding	NN
1519	1527	activity	activity	NN
1527	1528	.	.	.

1529	1531	In	in	IN
1532	1541	agreement	agreement	NN
1542	1546	with	with	IN
1547	1551	this	this	DT
1552	1559	finding	finding	NN
1559	1560	,	,	,
1561	1569	Northern	Northern	NNP
1570	1581	experiments	experiment	NNS
1582	1587	where	where	WRB
1588	1591	p65	p65	NN
1592	1595	and	and	CC
1596	1600	p105	p105	NN
1601	1605	mRNA	mrna	NN
1606	1612	levels	level	NNS
1613	1617	were	be	VBD
1618	1628	determined	determine	VBN
1628	1629	,	,	,
1630	1642	demonstrated	demonstrate	VBD
1643	1647	that	that	IN
1648	1658	expression	expression	NN
1659	1661	of	of	IN
1662	1667	these	these	DT
1668	1678	components	component	NNS
1679	1681	of	of	IN
1682	1685	the	the	DT
1686	1694	NF-kappa	NF-kappa	NNP
1695	1696	B	B	NNP
1697	1710	transcription	transcription	NN
1711	1717	factor	factor	NN
1718	1722	were	be	VBD
1723	1726	not	not	RB
1727	1735	affected	affect	VBN
1736	1738	by	by	IN
1739	1744	IL-10	il-10	NN
1745	1747	or	or	CC
1748	1752	IL-4	il-4	NN
1752	1753	.	.	.

1754	1765	Furthermore	furthermore	RB
1765	1766	,	,	,
1767	1774	neither	neither	CC
1775	1780	IL-10	il-10	NN
1781	1784	nor	nor	CC
1785	1789	IL-4	il-4	NN
1790	1796	showed	show	VBD
1797	1800	any	any	DT
1801	1807	effect	effect	NN
1808	1810	on	on	IN
1811	1818	I-kappa	I-kappa	NNP
1819	1820	B	B	NNP
1821	1825	mRNA	mrna	NN
1826	1836	expression	expression	NN
1837	1839	as	as	IN
1840	1850	determined	determine	VBN
1851	1853	by	by	IN
1854	1862	Northern	northern	NN
1863	1874	experiments	experiment	NNS
1874	1875	.	.	.

1876	1880	Thus	thus	RB
1880	1881	,	,	,
1882	1887	IL-10	il-10	NN
1888	1891	and	and	CC
1892	1896	IL-4	il-4	NN
1897	1906	similarly	similarly	RB
1907	1913	affect	affect	VBP
1914	1918	IL-6	il-6	NN
1919	1929	expression	expression	NN
1929	1930	.	.	.

1931	1938	However	however	RB
1938	1939	,	,	,
1940	1943	for	for	IN
1944	1948	IL-4	il-4	NN
1949	1953	this	this	DT
1954	1957	was	be	VBD
1958	1969	accompanied	accompany	VBN
1970	1974	with	with	IN
1975	1976	a	a	DT
1977	1986	reduction	reduction	NN
1987	1989	of	of	IN
1990	1994	AP-1	ap-1	NN
1995	1998	and	and	CC
1999	2005	NF-IL6	NF-IL6	NNP
2006	2013	binding	binding	NN
2014	2022	activity	activity	NN
2023	2030	whereas	whereas	IN
2031	2036	IL-10	IL-10	NNP
2037	2041	only	only	RB
2042	2051	inhibited	inhibit	VBD
2052	2056	AP-1	ap-1	NN
2057	2064	binding	binding	NN
2065	2073	activity	activity	NN
2073	2074	.	.	.