0	6	Signal	Signal	NNP
7	19	transduction	transduction	NN
20	22	by	by	IN
23	26	DR3	DR3	NNP
26	27	,	,	,
28	29	a	a	DT
30	35	death	death	NN
36	53	domain-containing	domain-containing	JJ
54	62	receptor	receptor	NN
63	70	related	related	JJ
71	73	to	to	TO
74	80	TNFR-1	TNFR-1	NNP
81	84	and	and	CC
85	89	CD95	CD95	NNP
89	90	.	.	.

92	97	Tumor	tumor	NN
98	106	necrosis	necrosis	NN
107	113	factor	factor	NN
114	124	receptor-1	receptor-1	NN
125	126	(	(	(
126	132	TNFR-1	tnfr-1	NN
132	133	)	)	)
134	137	and	and	CC
138	142	CD95	CD95	NNP
143	144	(	(	(
144	148	also	also	RB
149	155	called	call	VBN
156	159	Fas	Fas	NNP
160	162	or	or	CC
163	168	APO-1	APO-1	NNP
168	169	)	)	)
170	173	are	be	VBP
174	182	cytokine	cytokine	NN
183	192	receptors	receptor	NNS
193	197	that	that	WDT
198	204	engage	engage	VBP
205	208	the	the	DT
209	218	apoptosis	apoptosis	NN
219	226	pathway	pathway	NN
227	234	through	through	IN
235	236	a	a	DT
237	243	region	region	NN
244	246	of	of	IN
247	260	intracellular	intracellular	JJ
261	269	homology	homology	NN
269	270	,	,	,
271	281	designated	designate	VBN
282	285	the	the	DT
286	287	“	``	``
287	292	death	death	NN
293	299	domain	domain	NN
299	300	.	.	.
300	301	”	''	''

302	309	Another	another	DT
310	315	death	death	NN
316	333	domain-containing	domain-containing	JJ
334	340	member	member	NN
341	343	of	of	IN
344	347	the	the	DT
348	352	TNFR	TNFR	NNP
353	359	family	family	NN
359	360	,	,	,
361	366	death	death	NN
367	375	receptor	receptor	NN
376	377	3	3	CD
378	379	(	(	(
379	382	DR3	DR3	NNP
382	383	)	)	)
383	384	,	,	,
385	388	was	be	VBD
389	399	identified	identify	VBN
400	403	and	and	CC
404	407	was	be	VBD
408	413	shown	show	VBN
414	416	to	to	TO
417	423	induce	induce	VB
424	428	both	both	CC
429	438	apoptosis	apoptosis	NN
439	442	and	and	CC
443	453	activation	activation	NN
454	456	of	of	IN
457	464	nuclear	nuclear	JJ
465	471	factor	factor	NN
472	478	kappaB	kappab	NN
478	479	.	.	.

480	490	Expression	expression	NN
491	493	of	of	IN
494	497	DR3	DR3	NNP
498	505	appears	appear	VBZ
506	508	to	to	TO
509	511	be	be	VB
512	522	restricted	restrict	VBN
523	525	to	to	TO
526	533	tissues	tissue	NNS
534	542	enriched	enrich	VBN
543	545	in	in	IN
546	557	lymphocytes	lymphocyte	NNS
557	558	.	.	.

559	562	DR3	dr3	NN
563	569	signal	signal	NN
570	582	transduction	transduction	NN
583	585	is	be	VBZ
586	594	mediated	mediate	VBN
595	597	by	by	IN
598	599	a	a	DT
600	607	complex	complex	NN
608	610	of	of	IN
611	624	intracellular	intracellular	JJ
625	634	signaling	signal	VBG
635	644	molecules	molecule	NNS
645	654	including	include	VBG
655	660	TRADD	TRADD	NNP
660	661	,	,	,
662	667	TRAF2	TRAF2	NNP
667	668	,	,	,
669	673	FADD	FADD	NNP
673	674	,	,	,
675	678	and	and	CC
679	684	FLICE	FLICE	NNP
684	685	.	.	.

686	690	Thus	thus	RB
690	691	,	,	,
692	695	DR3	DR3	NNP
696	702	likely	likely	RB
703	708	plays	play	VBZ
709	710	a	a	DT
711	715	role	role	NN
716	718	in	in	IN
719	729	regulating	regulate	VBG
730	740	lymphocyte	lymphocyte	NN
741	752	homeostasis	homeostasis	NN
752	753	.	.	.