0	10	Regulation	regulation	NN
11	13	of	of	IN
14	30	interferon-gamma	interferon-gamma	NN
31	35	gene	gene	NN
36	46	expression	expression	NN
46	47	.	.	.

49	65	Interferon-gamma	Interferon-gamma	NNP
66	67	(	(	(
68	77	IFN-gamma	IFN-gamma	NNP
78	79	)	)	)
79	80	,	,	,
81	85	also	also	RB
86	91	known	know	VBN
92	94	as	as	IN
95	99	type	type	NN
100	102	II	ii	CD
103	113	interferon	interferon	NN
113	114	,	,	,
115	117	is	be	VBZ
118	120	an	an	DT
121	130	important	important	JJ
131	147	immunoregulatory	immunoregulatory	JJ
148	152	gene	gene	NN
153	157	that	that	WDT
158	161	has	have	VBZ
162	170	multiple	multiple	JJ
171	178	effects	effect	NNS
179	181	on	on	IN
182	185	the	the	DT
186	197	development	development	NN
197	198	,	,	,
199	209	maturation	maturation	NN
209	210	,	,	,
211	214	and	and	CC
215	223	function	function	NN
224	226	of	of	IN
227	230	the	the	DT
231	237	immune	immune	JJ
238	244	system	system	NN
244	245	.	.	.

246	255	IFN-gamma	IFN-gamma	NNP
256	260	mRNA	mRNA	NNP
261	264	and	and	CC
265	272	protein	protein	NN
273	276	are	be	VBP
277	286	expressed	express	VBN
287	300	predominantly	predominantly	RB
301	303	by	by	IN
304	305	T	t	NN
306	311	cells	cell	NNS
312	315	and	and	CC
316	321	large	large	JJ
322	330	granular	granular	JJ
331	342	lymphocytes	lymphocyte	NNS
342	343	.	.	.

344	347	The	the	DT
348	357	IFN-gamma	IFN-gamma	NNP
358	362	mRNA	mRNA	NNP
363	365	is	be	VBZ
366	383	induced/inhibited	induced/inhibite	VBN
384	386	in	in	IN
387	392	these	these	DT
393	397	cell	cell	NN
398	403	types	type	NNS
404	406	by	by	IN
407	408	a	a	DT
409	413	wide	wide	JJ
414	421	variety	variety	NN
422	424	of	of	IN
425	438	extracellular	extracellular	JJ
439	446	signals	signal	NNS
446	447	,	,	,
448	452	thus	thus	RB
453	464	implicating	implicate	VBG
465	466	a	a	DT
467	473	number	number	NN
474	476	of	of	IN
477	484	diverse	diverse	JJ
484	485	,	,	,
486	489	yet	yet	RB
490	500	convergent	convergent	JJ
501	507	signal	signal	NN
508	520	transduction	transduction	NN
521	529	pathways	pathway	NNS
530	532	in	in	IN
533	536	its	its	PRP$
537	552	transcriptional	transcriptional	JJ
553	560	control	control	NN
560	561	.	.	.

562	564	In	in	IN
565	569	this	this	DT
570	576	review	review	NN
576	577	,	,	,
578	579	I	I	PRP
580	588	describe	describe	VBP
589	592	how	how	WRB
593	596	DNA	DNA	NNP
597	608	methylation	methylation	NN
609	612	and	and	CC
613	621	specific	specific	JJ
622	625	DNA	dna	NN
626	633	binding	binding	NN
634	642	proteins	protein	NNS
643	646	may	may	MD
647	655	regulate	regulate	VB
656	669	transcription	transcription	NN
670	672	of	of	IN
673	676	the	the	DT
677	686	IFN-gamma	IFN-gamma	NNP
687	691	gene	gene	NN
692	694	in	in	IN
695	703	response	response	NN
704	706	to	to	TO
707	720	extracellular	extracellular	JJ
721	728	signals	signal	NNS
728	729	.	.	.