0 9 Induction Induction NNP 10 12 of of IN 13 21 vascular vascular JJ 22 26 cell cell NN 27 35 adhesion adhesion NN 36 46 molecule-1 molecule-1 NN 47 49 by by IN 50 61 low-density low-density JJ 62 73 lipoprotein lipoprotein NN 73 74 . . . 76 87 Low-density low-density JJ 88 99 lipoprotein lipoprotein NN 100 101 ( ( ( 101 104 LDL LDL NNP 104 105 ) ) ) 106 108 is be VBZ 109 110 a a DT 111 127 well-established well-established JJ 128 132 risk risk NN 133 139 factor factor NN 140 143 for for IN 144 159 atherosclerosis atherosclerosis NN 159 160 . . . 161 165 When when WRB 166 177 endothelial endothelial JJ 178 183 cells cell NNS 184 187 are be VBP 188 197 incubated incubate VBN 198 202 with with IN 203 207 this this DT 208 219 lipoprotein lipoprotein NN 220 222 in in IN 223 239 pathophysiologic pathophysiologic JJ 240 247 amounts amount NNS 247 248 , , , 249 252 the the DT 253 258 cells cell NNS 259 262 are be VBP 263 272 activated activate VBN 272 273 . . . 274 279 Among among IN 280 283 the the DT 284 294 documented document VBN 295 303 cellular cellular JJ 304 313 responses response NNS 314 316 to to TO 317 320 LDL LDL NNP 321 323 is be VBZ 324 333 increased increase VBN 334 345 recruitment recruitment NN 346 348 of of IN 349 358 monocytes monocyte NNS 358 359 , , , 360 365 which which WDT 366 369 are be VBP 370 378 believed believe VBN 379 381 to to TO 382 386 play play VB 387 388 a a DT 389 394 major major JJ 395 399 role role NN 400 402 in in IN 403 412 promoting promote VBG 413 420 intimal intimal JJ 421 427 plaque plaque NN 428 437 formation formation NN 437 438 . . . 439 442 The the DT 443 451 findings finding NNS 452 461 presented present VBN 462 466 here here RB 467 471 link link VBP 472 474 an an DT 475 485 atheogenic atheogenic JJ 486 497 lipoprotein lipoprotein NN 497 498 , , , 499 502 LDL LDL NNP 502 503 , , , 504 508 with with IN 509 512 the the DT 513 522 induction induction NN 523 525 of of IN 526 528 an an DT 529 537 adhesion adhesion NN 538 546 molecule molecule NN 547 556 important important JJ 557 559 in in IN 560 573 atherogenesis atherogenesis NN 574 579 Human human JJ 580 583 LDL LDL NNP 584 591 induces induce VBZ 592 595 the the DT 596 604 vascular vascular JJ 605 609 cell cell NN 610 618 adhesion adhesion NN 619 629 molecule-1 molecule-1 NN 630 631 ( ( ( 631 637 VCAM-1 vcam-1 NN 637 638 ) ) ) 639 656 transcriptionally transcriptionally RB 657 661 with with IN 662 664 an an DT 665 673 increase increase NN 674 676 in in IN 677 681 mRNA mrna NN 682 688 levels level NNS 689 696 through through IN 697 707 activation activation NN 708 710 of of IN 711 714 the the DT 715 719 VCAM VCAM NNP 720 728 promoter promoter NN 728 729 . . . 730 734 This this DT 735 741 effect effect NN 742 744 is be VBZ 745 752 blocked block VBN 753 755 by by IN 756 765 anti-VCAM anti-vcam JJ 766 776 antibodies antibody NNS 776 777 . . . 778 783 After after IN 784 785 a a DT 786 791 2-day 2-day JJ 792 802 incubation incubation NN 803 805 in in IN 806 809 LDL LDL NNP 809 810 , , , 811 814 the the DT 815 822 binding binding NN 823 825 of of IN 826 834 NF-kappa NF-kappa NNP 835 836 B B NNP 836 837 , , , 838 843 which which WDT 844 846 is be VBZ 847 855 believed believe VBN 856 858 to to TO 859 861 be be VB 862 863 a a DT 864 867 key key JJ 868 884 oxidative-stress oxidative-stress NN 885 891 sensor sensor NN 892 895 for for IN 896 900 VCAM VCAM NNP 901 911 regulation regulation NN 911 912 , , , 913 920 remains remain VBZ 921 923 at at IN 924 929 basal basal JJ 930 935 level level NN 935 936 . . . 937 939 In in IN 940 948 contrast contrast NN 948 949 , , , 950 953 the the DT 954 961 binding binding NN 962 972 activities activity NNS 973 975 of of IN 976 980 AP-1 AP-1 NNP 981 984 and and CC 985 989 GATA GATA NNP 989 990 , , , 991 993 on on IN 994 997 the the DT 998 1003 other other JJ 1004 1008 hand hand NN 1008 1009 , , , 1010 1013 are be VBP 1014 1023 increased increase VBN 1024 1026 by by IN 1027 1030 LDL LDL NNP 1030 1031 . . . 1032 1036 Thus thus RB 1036 1037 , , , 1038 1039 a a DT 1040 1049 component component NN 1050 1052 of of IN 1053 1065 LDL-enhanced ldl-enhanced JJ 1066 1077 endothelial endothelial JJ 1078 1089 recruitment recruitment NN 1090 1092 of of IN 1093 1102 monocytes monocyte NNS 1103 1105 is be VBZ 1106 1116 attributed attribute VBN 1117 1119 to to TO 1120 1126 VCAM-1 vcam-1 NN 1127 1137 expression expression NN 1137 1138 , , , 1139 1144 which which WDT 1145 1152 appears appear VBZ 1153 1155 to to TO 1156 1158 be be VB 1159 1167 mediated mediate VBN 1168 1175 through through IN 1176 1180 AP-1 AP-1 NNP 1181 1184 and and CC 1185 1189 GATA GATA NNP 1189 1190 . . . 1191 1196 These these DT 1197 1201 data datum NNS 1202 1210 identify identify VBP 1211 1214 LDL LDL NNP 1215 1217 as as IN 1218 1219 a a DT 1220 1232 VCAM-inducer vcam-inducer NN 1233 1241 possibly possibly RB 1242 1250 distinct distinct JJ 1251 1255 from from IN 1256 1265 cytokines cytokine NNS 1266 1269 and and CC 1270 1279 endotoxin endotoxin NN 1279 1280 . . .