0 5 Genes gene NNS 6 10 that that WDT 11 19 regulate regulate VBP 20 33 interleukin-4 interleukin-4 NN 34 44 expression expression NN 45 47 in in IN 48 49 T t NN 50 55 cells cell NNS 55 56 . . . 58 71 Interleukin-4 interleukin-4 NN 72 74 is be VBZ 75 77 an an DT 78 94 immunomodulatory immunomodulatory JJ 95 103 cytokine cytokine NN 104 109 which which WDT 110 115 plays play VBZ 116 117 a a DT 118 125 central central JJ 126 130 role role NN 131 133 in in IN 134 137 the the DT 138 148 regulation regulation NN 149 151 of of IN 152 160 allergic allergic JJ 161 164 and and CC 165 171 atopic atopic JJ 172 178 immune immune JJ 179 188 responses response NNS 188 189 . . . 190 201 Significant significant JJ 202 210 progress progress NN 211 214 has have VBZ 215 219 been be VBN 220 224 made make VBN 225 227 in in IN 228 235 gaining gain VBG 236 237 a a DT 238 246 detailed detailed JJ 247 260 understanding understanding NN 261 263 of of IN 264 267 the the DT 268 283 transcriptional transcriptional JJ 284 294 regulation regulation NN 295 297 of of IN 298 301 the the DT 302 315 interleukin-4 interleukin-4 NN 316 320 gene gene NN 320 321 . . . 322 325 The the DT 326 332 recent recent JJ 333 347 identification identification NN 348 351 and and CC 352 368 characterization characterization NN 369 371 of of IN 372 379 several several JJ 380 383 key key JJ 384 397 transcription transcription NN 398 405 factors factor NNS 406 409 has have VBZ 410 416 helped help VBN 417 419 to to TO 420 429 elucidate elucidate VB 430 433 the the DT 434 443 molecular molecular JJ 444 454 mechanisms mechanism NNS 455 457 of of IN 458 459 T t NN 460 466 helper helper NN 467 471 cell cell NN 472 480 cytokine cytokine NN 481 485 gene gene NN 486 496 expression expression NN 496 497 . . .