0	12	Differential	differential	JJ
13	23	expression	expression	NN
24	27	and	and	CC
28	43	phosphorylation	phosphorylation	NN
44	46	of	of	IN
47	51	CTCF	CTCF	NNP
51	52	,	,	,
53	54	a	a	DT
55	60	c-myc	c-myc	NN
61	76	transcriptional	transcriptional	JJ
77	86	regulator	regulator	NN
86	87	,	,	,
88	94	during	during	IN
95	110	differentiation	differentiation	NN
111	113	of	of	IN
114	119	human	human	JJ
120	127	myeloid	myeloid	JJ
128	133	cells	cell	NNS
133	134	.	.	.

136	140	CTCF	CTCF	NNP
141	143	is	be	VBZ
144	145	a	a	DT
146	161	transcriptional	transcriptional	JJ
162	171	repressor	repressor	NN
172	174	of	of	IN
175	178	the	the	DT
179	184	c-myc	c-myc	NN
185	189	gene	gene	NN
189	190	.	.	.

191	199	Although	although	IN
200	204	CTCF	CTCF	NNP
205	208	has	have	VBZ
209	213	been	be	VBN
214	227	characterized	characterize	VBN
228	230	in	in	IN
231	235	some	some	DT
236	242	detail	detail	NN
242	243	,	,	,
244	249	there	there	EX
250	252	is	be	VBZ
253	257	very	very	RB
258	264	little	little	JJ
265	276	information	information	NN
277	282	about	about	IN
283	286	the	the	DT
287	297	regulation	regulation	NN
298	300	of	of	IN
301	305	CTCF	CTCF	NNP
306	314	activity	activity	NN
314	315	.	.	.

316	325	Therefore	therefore	RB
326	328	we	we	PRP
329	341	investigated	investigate	VBD
342	346	CTCF	CTCF	NNP
347	357	expression	expression	NN
358	361	and	and	CC
362	377	phosphorylation	phosphorylation	NN
378	384	during	during	IN
385	392	induced	induce	VBN
393	408	differentiation	differentiation	NN
409	411	of	of	IN
412	417	human	human	JJ
418	425	myeloid	myeloid	JJ
426	434	leukemia	leukemia	NN
435	440	cells	cell	NNS
440	441	.	.	.

442	444	We	we	PRP
445	450	found	find	VBD
451	455	that	that	IN
455	456	:	:	:
457	458	(	(	(
458	459	i	i	LS
459	460	)	)	)
461	465	both	both	CC
466	470	CTCF	CTCF	NNP
471	475	mRNA	mRNA	NNP
476	479	and	and	CC
480	487	protein	protein	NN
488	491	are	be	VBP
492	506	down-regulated	down-regulate	VBN
507	513	during	during	IN
514	522	terminal	terminal	JJ
523	538	differentiation	differentiation	NN
539	541	in	in	IN
542	546	most	most	JJS
547	551	cell	cell	NN
552	557	lines	line	NNS
558	564	tested	test	VBN
564	565	;	;	:
566	567	(	(	(
567	569	ii	ii	LS
569	570	)	)	)
571	575	CTCF	CTCF	NNP
576	591	down-regulation	down-regulation	NN
592	594	is	be	VBZ
595	603	retarded	retard	VBN
604	607	and	and	CC
608	612	less	less	RBR
613	623	pronounced	pronounced	JJ
624	628	than	than	IN
629	633	that	that	DT
634	636	of	of	IN
637	642	c-myc	c-myc	NN
642	643	;	;	:
644	645	(	(	(
645	648	iii	iii	LS
648	649	)	)	)
650	654	CTCF	CTCF	NNP
655	662	protein	protein	NN
663	665	is	be	VBZ
666	680	differentially	differentially	RB
681	695	phosphorylated	phosphorylate	VBN
696	699	and	and	CC
700	703	the	the	DT
704	719	phosphorylation	phosphorylation	NN
720	728	profiles	profile	NNS
729	735	depend	depend	VBP
736	738	on	on	IN
739	742	the	the	DT
743	758	differentiation	differentiation	NN
759	766	pathway	pathway	NN
766	767	.	.	.

768	770	We	we	PRP
771	780	concluded	conclude	VBD
781	785	that	that	IN
786	790	CTCF	CTCF	NNP
791	801	expression	expression	NN
802	805	and	and	CC
806	814	activity	activity	NN
815	817	is	be	VBZ
818	828	controlled	control	VBN
829	831	at	at	IN
832	847	transcriptional	transcriptional	JJ
848	851	and	and	CC
852	872	post-transcriptional	post-transcriptional	JJ
873	879	levels	level	NNS
879	880	.	.	.