0 1 [ [ ( 1 11 Corticoids corticoid NNS 12 15 and and CC 16 23 allergy allergy NN 23 24 ] ] ) 26 38 Inflammation Inflammation NNP 39 41 is be VBZ 42 52 constantly constantly RB 53 61 observed observe VBN 62 64 in in IN 65 73 allergic allergic JJ 74 83 reactions reaction NNS 83 84 . . . 85 100 Corticosteroids corticosteroid NNS 101 104 are be VBP 105 109 most most RBS 110 119 effective effective JJ 120 122 in in IN 123 133 preventing prevent VBG 134 137 the the DT 138 142 late late JJ 143 148 phase phase NN 149 151 of of IN 152 160 allergic allergic JJ 161 169 reaction reaction NN 169 170 . . . 171 174 The the DT 175 181 action action NN 182 184 of of IN 185 205 glucocorticosteroids glucocorticosteroid NNS 206 208 is be VBZ 209 217 mediated mediate VBN 218 225 through through IN 226 240 glucocorticoid glucocorticoid NN 241 250 receptors receptor NNS 251 258 present present JJ 259 261 in in IN 262 265 the the DT 266 274 cellular cellular JJ 275 284 cytoplasm cytoplasm NN 284 285 . . . 286 290 When when WRB 291 300 activated activate VBN 300 301 , , , 302 316 glucocorticoid glucocorticoid NN 317 326 receptors receptor NNS 327 331 form form VBP 332 333 a a DT 334 339 dimer dimer NN 340 343 and and CC 344 348 bind bind VBP 349 351 to to TO 352 355 DNA dna NN 356 361 after after IN 362 371 migration migration NN 372 376 into into IN 377 380 the the DT 381 388 nucleus nucleus NN 388 389 . . . 390 401 Interaction Interaction NNP 402 404 to to TO 405 408 DNA DNA NNP 409 416 induces induce VBZ 417 424 changes change NNS 425 427 in in IN 428 431 the the DT 432 445 transcription transcription NN 446 450 rate rate NN 450 451 , , , 452 459 leading lead VBG 460 462 to to TO 463 469 either either CC 470 474 gene gene NN 475 484 induction induction NN 485 487 or or CC 488 492 gene gene NN 493 503 repression repression NN 503 504 . . . 505 519 Glucocorticoid glucocorticoid NN 520 529 receptors receptor NNS 530 533 are be VBP 534 538 also also RB 539 543 able able JJ 544 546 to to TO 547 555 interact interact VB 556 560 with with IN 561 576 transcriptional transcriptional JJ 577 584 factors factor NNS 585 589 such such JJ 590 592 as as IN 593 597 AP-1 ap-1 NN 598 599 ( ( ( 599 608 activator activator NN 609 618 protein-1 protein-1 NN 618 619 ) ) ) 620 622 of of IN 623 631 NF-kappa NF-kappa NNP 632 633 B B NNP 634 635 ( ( ( 635 642 nuclear nuclear JJ 643 655 factor-kappa factor-kappa NN 656 657 B B NNP 657 658 ) ) ) 658 659 . . . 660 667 Through through IN 668 673 these these DT 674 681 actions action NNS 682 702 glucocorticosteroids glucocorticosteroid NNS 703 706 are be VBP 707 718 susceptible susceptible JJ 719 721 to to TO 722 728 modify modify VB 729 738 functions function NNS 739 741 of of IN 742 747 cells cell NNS 748 756 involved involve VBN 757 759 in in IN 760 763 the the DT 764 772 allergic allergic JJ 773 785 inflammatory inflammatory JJ 786 794 response response NN 794 795 . . . 796 800 They they PRP 801 804 are be VBP 805 807 in in IN 808 818 particular particular JJ 819 823 able able JJ 824 826 to to TO 827 834 inhibit inhibit VB 835 839 most most JJS 840 842 of of IN 843 846 the the DT 847 863 pro-inflammatory pro-inflammatory JJ 864 873 functions function NNS 874 876 of of IN 877 880 the the DT 881 892 eosinophils eosinophil NNS 892 893 . . .