0 10 Engagement engagement NN 11 13 of of IN 14 21 natural natural JJ 22 34 cytotoxicity cytotoxicity NN 35 43 programs program NNS 44 53 regulates regulate VBZ 54 58 AP-1 ap-1 NN 59 69 expression expression NN 70 72 in in IN 73 76 the the DT 77 80 NKL NKL NNP 81 86 human human JJ 87 89 NK NK NNP 90 94 cell cell NN 95 99 line line NN 99 100 . . . 102 104 NK NK NNP 105 109 cell cell NN 110 122 cytotoxicity cytotoxicity NN 123 125 is be VBZ 126 127 a a DT 128 132 fast fast JJ 133 136 and and CC 137 146 efficient efficient JJ 147 156 mechanism mechanism NN 157 159 of of IN 160 166 target target NN 167 171 cell cell NN 172 177 lysis lysis NN 177 178 . . . 179 184 Using use VBG 185 198 transcription transcription NN 199 207 analysis analysis NN 207 208 , , , 209 213 such such JJ 214 216 as as IN 217 226 multiplex multiplex JJ 227 236 messenger messenger NN 237 243 assays assay NNS 243 244 , , , 245 247 we we PRP 248 252 show show VBP 253 257 here here RB 258 262 that that IN 263 270 natural natural JJ 271 283 cytotoxicity cytotoxicity NN 284 291 exerted exert VBN 292 294 by by IN 295 298 the the DT 299 304 human human JJ 305 308 NKL NKL NNP 309 313 cell cell NN 314 318 line line NN 319 329 correlates correlate VBZ 330 334 with with IN 335 339 mRNA mrna NN 340 352 accumulation accumulation NN 353 355 of of IN 356 360 very very RB 361 366 early early JJ 367 376 activator activator NN 377 384 protein protein NN 385 386 ( ( ( 386 391 AP)-1 ap)-1 NN 392 405 transcription transcription NN 406 412 factor factor NN 413 418 genes gene NNS 419 423 such such JJ 424 426 as as IN 427 431 JunB JunB NNP 431 432 , , , 433 437 FosB FosB NNP 438 441 and and CC 442 447 c-Fos c-fos NN 447 448 . . . 449 451 In in IN 452 460 addition addition NN 460 461 , , , 462 473 DNA-binding dna-binding JJ 474 484 activities activity NNS 485 487 of of IN 488 495 Jun-Fos Jun-Fos NNP 496 508 heterodimers heterodimer NNS 509 513 were be VBD 514 522 observed observe VBN 523 525 by by IN 526 541 electrophoretic electrophoretic JJ 542 550 mobility mobility NN 551 556 shift shift NN 557 563 assays assay NNS 564 570 during during IN 571 574 the the DT 575 581 course course NN 582 584 of of IN 585 592 natural natural JJ 593 605 cytotoxicity cytotoxicity NN 605 606 . . . 607 618 Interaction interaction NN 619 626 between between IN 627 646 immunoglobulin-like immunoglobulin-like JJ 647 669 transcript-2/leukocyte transcript-2/leukocyte NN 670 677 Ig-like ig-like JJ 678 686 receptor receptor NN 687 688 1 1 CD 689 691 on on IN 692 695 NKL nkl NN 696 701 cells cell NNS 702 705 and and CC 706 713 HLA-B27 hla-b27 NN 714 716 on on IN 717 723 target target NN 724 729 cells cell NNS 730 735 leads lead VBZ 736 738 to to TO 739 741 an an DT 742 752 impairment impairment NN 753 755 of of IN 756 759 NKL NKL NNP 760 767 natural natural JJ 768 780 cytotoxicity cytotoxicity NN 780 781 , , , 782 787 which which WDT 788 798 correlates correlate VBZ 799 803 with with IN 804 806 an an DT 807 814 absence absence NN 815 817 of of IN 818 822 JunB JunB NNP 822 823 , , , 824 828 FosB FosB NNP 828 829 , , , 830 833 and and CC 834 839 c-Fos c-fos NN 840 853 transcription transcription NN 853 854 , , , 855 857 as as RB 858 862 well well RB 863 865 as as IN 866 868 an an DT 869 876 absence absence NN 877 879 of of IN 880 885 their their PRP$ 886 897 DNA-binding dna-binding JJ 898 906 activity activity NN 906 907 . . . 908 911 Our our PRP$ 912 919 studies study NNS 920 924 thus thus RB 925 933 indicate indicate VBP 934 938 that that IN 938 939 , , , 940 947 despite despite IN 948 951 the the DT 952 960 rapidity rapidity NN 961 963 of of IN 964 966 NK NK NNP 967 980 cell-mediated cell-mediated JJ 981 986 lysis lysis NN 986 987 , , , 988 992 AP-1 ap-1 NN 993 1006 transcription transcription NN 1007 1013 factor factor NN 1014 1016 is be VBZ 1017 1026 activated activate VBN 1027 1033 during during IN 1034 1037 the the DT 1038 1043 early early JJ 1044 1049 stage stage NN 1050 1052 of of IN 1053 1055 NK NK NNP 1056 1060 cell cell NN 1061 1070 cytolytic cytolytic JJ 1071 1079 programs program NNS 1080 1083 and and CC 1084 1088 that that IN 1089 1099 engagement engagement NN 1100 1102 of of IN 1103 1105 NK NK NNP 1106 1110 cell cell NN 1111 1121 inhibitory inhibitory JJ 1122 1131 receptors receptor NNS 1132 1135 for for IN 1136 1139 MHC MHC NNP 1140 1145 class class NN 1146 1147 I i CD 1148 1157 molecules molecule NNS 1158 1165 impairs impair VBZ 1166 1169 the the DT 1170 1174 very very RB 1175 1180 early early JJ 1181 1191 activation activation NN 1192 1194 of of IN 1195 1199 AP-1 ap-1 NN 1199 1200 . . .