0 6 Signal Signal NNP 7 19 transduction transduction NN 20 28 pathways pathway NNS 29 38 activated activate VBN 39 41 in in IN 42 53 endothelial endothelial JJ 54 59 cells cell NNS 60 69 following follow VBG 70 79 infection infection NN 80 84 with with IN 85 94 Chlamydia Chlamydia NNP 95 105 pneumoniae pneumoniae NNP 105 106 . . . 108 117 Chlamydia chlamydia FW 118 128 pneumoniae pneumoniae FW 129 131 is be VBZ 132 134 an an DT 135 144 important important JJ 145 156 respiratory respiratory JJ 157 165 pathogen pathogen NN 165 166 . . . 167 175 Recently recently RB 175 176 , , , 177 180 its its PRP$ 181 189 presence presence NN 190 193 has have VBZ 194 198 been be VBN 199 211 demonstrated demonstrate VBN 212 214 in in IN 215 230 atherosclerotic atherosclerotic JJ 231 238 lesions lesion NNS 238 239 . . . 240 242 In in IN 243 247 this this DT 248 253 study study NN 253 254 , , , 255 257 we we PRP 258 271 characterized characterize VBD 272 274 C. c. FW 275 294 pneumoniae-mediated pneumoniae-mediated JJ 295 305 activation activation NN 306 308 of of IN 309 320 endothelial endothelial JJ 321 326 cells cell NNS 327 330 and and CC 331 343 demonstrated demonstrate VBD 344 346 an an DT 347 355 enhanced enhance VBN 356 366 expression expression NN 367 369 of of IN 370 381 endothelial endothelial JJ 382 390 adhesion adhesion NN 391 400 molecules molecule NNS 401 409 followed follow VBN 410 412 by by IN 413 423 subsequent subsequent JJ 424 431 rolling rolling NN 431 432 , , , 433 441 adhesion adhesion NN 441 442 , , , 443 446 and and CC 447 461 transmigration transmigration NN 462 464 of of IN 465 475 leukocytes leukocyte NNS 476 477 ( ( ( 477 486 monocytes monocyte NNS 486 487 , , , 488 500 granulocytes granulocyte NNS 500 501 ) ) ) 501 502 . . . 503 508 These these DT 509 516 effects effect NNS 517 521 were be VBD 522 529 blocked block VBN 530 532 by by IN 533 537 mAbs mab NNS 538 545 against against IN 546 557 endothelial endothelial JJ 558 564 and/or and/or CC 565 574 leukocyte leukocyte NN 575 583 adhesion adhesion NN 584 593 molecules molecule NNS 594 595 ( ( ( 595 600 beta1 beta1 NN 601 604 and and CC 605 610 beta2 beta2 NN 611 620 integrins integrin NNS 620 621 ) ) ) 621 622 . . . 623 635 Additionally additionally RB 635 636 , , , 637 647 activation activation NN 648 650 of of IN 651 660 different different JJ 661 667 signal signal NN 668 680 transduction transduction NN 681 689 pathways pathway NNS 690 692 in in IN 693 695 C. c. FW 696 715 pneumoniae-infected pneumoniae-infected JJ 716 727 endothelial endothelial JJ 728 733 cells cell NNS 734 737 was be VBD 738 743 shown show VBN 743 744 : : : 745 752 protein protein NN 753 761 tyrosine tyrosine NN 762 777 phosphorylation phosphorylation NN 777 778 , , , 779 792 up-regulation up-regulation NN 793 795 of of IN 796 810 phosphorylated phosphorylate VBN 811 818 p42/p44 p42/p44 NN 819 836 mitogen-activated mitogen-activated JJ 837 844 protein protein NN 845 851 kinase kinase NNP 851 852 , , , 853 856 and and CC 857 866 NF-kappaB NF-kappaB NNP 867 891 activation/translocation activation/translocation NN 892 900 occurred occur VBD 901 907 within within IN 908 913 10-15 10-15 CD 914 918 min. min. NN 919 928 Increased increase VBD 929 933 mRNA mrna NN 934 937 and and CC 938 945 surface surface NN 946 956 expression expression NN 957 959 of of IN 960 970 E-selectin E-selectin NNP 970 971 , , , 972 978 ICAM-1 ICAM-1 NNP 978 979 , , , 980 983 and and CC 984 990 VCAM-1 vcam-1 NN 991 995 were be VBD 996 1001 noted note VBN 1002 1008 within within IN 1009 1014 hours hour NNS 1014 1015 . . . 1016 1020 Thus thus RB 1020 1021 , , , 1022 1024 C. c. FW 1025 1035 pneumoniae pneumoniae FW 1036 1044 triggers trigger VBZ 1045 1046 a a DT 1047 1054 cascade cascade NN 1055 1057 of of IN 1058 1064 events event NNS 1065 1069 that that WDT 1070 1075 could could MD 1076 1080 lead lead VB 1081 1083 to to TO 1084 1095 endothelial endothelial JJ 1096 1106 activation activation NN 1106 1107 , , , 1108 1120 inflammation inflammation NN 1120 1121 , , , 1122 1125 and and CC 1126 1136 thrombosis thrombosis NN 1136 1137 , , , 1138 1143 which which WDT 1144 1146 in in IN 1147 1151 turn turn NN 1152 1155 may may MD 1156 1162 result result VB 1163 1165 in in IN 1166 1168 or or CC 1169 1172 may may MD 1173 1180 promote promote VB 1181 1196 atherosclerosis atherosclerosis NN 1196 1197 . . .