0 16 SHP2-interacting shp2-interacting JJ 17 30 transmembrane transmembrane JJ 31 38 adaptor adaptor NN 39 46 protein protein NN 47 48 ( ( ( 48 51 SIT SIT NNP 51 52 ) ) ) 52 53 , , , 54 55 a a DT 56 61 novel novel JJ 62 78 disulfide-linked disulfide-linked JJ 79 84 dimer dimer NN 85 95 regulating regulate VBG 96 101 human human JJ 102 103 T t NN 104 108 cell cell NN 109 119 activation activation NN 119 120 . . . 122 123 T t NN 124 135 lymphocytes lymphocyte NNS 136 143 express express VBP 144 151 several several JJ 152 155 low low JJ 156 165 molecular molecular JJ 166 172 weight weight NN 173 186 transmembrane transmembrane JJ 187 194 adaptor adaptor NN 195 203 proteins protein NNS 204 208 that that WDT 209 216 recruit recruit VBP 217 220 src src NN 221 229 homology homology NN 230 231 ( ( ( 231 235 SH)2 sh)2 NN 236 253 domain-containing domain-containing JJ 254 267 intracellular intracellular JJ 268 277 molecules molecule NNS 278 280 to to TO 281 284 the the DT 285 289 cell cell NN 290 298 membrane membrane NN 299 302 via via IN 303 317 tyrosine-based tyrosine-based JJ 318 327 signaling signaling NN 328 334 motifs motif NNS 334 335 . . . 336 338 We we PRP 339 347 describe describe VBP 348 352 here here RB 353 354 a a DT 355 360 novel novel JJ 361 369 molecule molecule NN 370 372 of of IN 373 377 this this DT 378 383 group group NN 384 390 termed term VBN 391 394 SIT SIT NNP 395 396 ( ( ( 396 400 SHP2 SHP2 NNP 401 412 interacting interact VBG 413 426 transmembrane transmembrane JJ 427 434 adaptor adaptor NN 435 442 protein protein NN 442 443 ) ) ) 443 444 . . . 445 448 SIT sit NN 449 451 is be VBZ 452 453 a a DT 454 470 disulfide-linked disulfide-linked JJ 471 482 homodimeric homodimeric JJ 483 495 glycoprotein glycoprotein NN 496 500 that that WDT 501 503 is be VBZ 504 513 expressed express VBN 514 516 in in IN 517 528 lymphocytes lymphocyte NNS 528 529 . . . 530 535 After after IN 536 544 tyrosine tyrosine NN 545 560 phosphorylation phosphorylation NN 561 563 by by IN 564 567 src src NN 568 571 and and CC 572 580 possibly possibly RB 581 584 syk syk NN 585 592 protein protein NN 593 601 tyrosine tyrosine NN 602 609 kinases kinase NNS 610 613 SIT sit NN 614 622 recruits recruit VBZ 623 626 the the DT 627 630 SH2 sh2 NN 631 648 domain-containing domain-containing JJ 649 657 tyrosine tyrosine NN 658 669 phosphatase phosphatase NN 670 674 SHP2 shp2 NN 675 678 via via IN 679 681 an an DT 682 696 immunoreceptor immunoreceptor NN 697 711 tyrosine-based tyrosine-based JJ 712 722 inhibition inhibition NN 723 728 motif motif NN 728 729 . . . 730 744 Overexpression Overexpression NNP 745 747 of of IN 748 751 SIT SIT NNP 752 754 in in IN 755 761 Jurkat Jurkat NNP 762 767 cells cell NNS 768 781 downmodulates downmodulate VBZ 782 783 T t NN 784 788 cell cell NN 789 798 receptor- receptor- NN 799 802 and and CC 803 830 phytohemagglutinin-mediated phytohemagglutinin-mediated JJ 831 841 activation activation NN 842 844 of of IN 845 848 the the DT 849 856 nuclear nuclear JJ 857 863 factor factor NN 864 866 of of IN 867 876 activated activate VBN 877 878 T t NN 879 884 cells cell NNS 885 886 ( ( ( 886 891 NF-AT NF-AT NNP 891 892 ) ) ) 893 895 by by IN 896 907 interfering interfere VBG 908 912 with with IN 913 922 signaling signaling NN 923 932 processes process NNS 933 937 that that WDT 938 941 are be VBP 942 950 probably probably RB 951 958 located located JJ 959 967 upstream upstream RB 968 970 of of IN 971 981 activation activation NN 982 984 of of IN 985 998 phospholipase phospholipase NN 999 1000 C C NNP 1000 1001 . . . 1002 1009 However however RB 1009 1010 , , , 1011 1018 binding binding NN 1019 1021 of of IN 1022 1026 SHP2 shp2 NN 1027 1029 to to TO 1030 1033 SIT SIT NNP 1034 1036 is be VBZ 1037 1040 not not RB 1041 1049 required require VBN 1050 1053 for for IN 1054 1064 inhibition inhibition NN 1065 1067 of of IN 1068 1073 NF-AT NF-AT NNP 1074 1083 induction induction NN 1083 1084 , , , 1085 1095 suggesting suggest VBG 1096 1100 that that IN 1101 1104 SIT sit NN 1105 1108 not not RB 1109 1113 only only RB 1114 1123 regulates regulate VBZ 1124 1129 NF-AT NF-AT NNP 1130 1138 activity activity NN 1139 1142 but but CC 1143 1147 also also RB 1148 1156 controls control VBZ 1157 1162 NF-AT nf-at NN 1163 1172 unrelated unrelated JJ 1173 1181 pathways pathway NNS 1182 1184 of of IN 1185 1186 T t NN 1187 1191 cell cell NN 1192 1202 activation activation NN 1203 1212 involving involve VBG 1213 1217 SHP2 shp2 NN 1217 1218 . . .