0 10 Resistance resistance NN 11 13 to to TO 14 19 tumor tumor NN 20 28 necrosis necrosis NN 29 35 factor factor NN 36 43 induced induced JJ 44 53 apoptosis apoptosis NN 54 56 in in FW 57 62 vitro vitro FW 63 73 correlates correlate VBZ 74 78 with with IN 79 83 high high JJ 84 94 metastatic metastatic JJ 95 103 capacity capacity NN 104 106 of of IN 107 112 cells cell NNS 113 115 in in FW 116 120 vivo vivo FW 120 121 . . . 123 126 TNF TNF NNP 127 129 is be VBZ 130 133 one one CD 134 136 of of IN 137 140 the the DT 141 150 cytokines cytokine NNS 151 159 secreted secrete VBN 160 162 by by IN 163 166 the the DT 167 172 cells cell NNS 173 175 of of IN 176 179 the the DT 180 186 immune immune JJ 187 193 system system NN 193 194 . . . 195 198 Our our PRP$ 199 203 data datum NNS 204 215 demonstrate demonstrate VBP 216 220 that that IN 221 226 those those DT 227 231 cell cell NN 232 237 lines line NNS 238 245 lacking lack VBG 246 256 capability capability NN 257 259 to to TO 260 264 form form VB 265 275 metastatic metastatic JJ 276 282 tumors tumor NNS 283 285 in in FW 286 290 vivo vivo FW 291 294 are be VBP 295 306 susceptible susceptible JJ 307 309 to to TO 310 313 TNF TNF NNP 314 321 induced induced JJ 322 331 apoptosis apoptosis NN 332 334 in in FW 335 340 vitro vitro FW 340 341 . . . 342 349 However however RB 349 350 , , , 351 355 cell cell NN 356 361 lines line NNS 362 366 with with IN 367 371 high high JJ 372 382 metastatic metastatic JJ 383 392 potential potential NN 393 396 are be VBP 397 406 resistant resistant JJ 407 409 to to TO 410 413 TNF TNF NNP 414 416 in in FW 417 422 vitro vitro FW 422 423 . . . 424 435 Furthermore furthermore RB 435 436 , , , 437 440 the the DT 441 445 same same JJ 446 450 cell cell NN 451 456 lines line NNS 457 461 were be VBD 462 471 resistant resistant JJ 472 474 to to TO 475 484 cytolytic cytolytic JJ 485 491 action action NN 492 494 of of IN 495 500 other other JJ 501 510 cytotoxic cytotoxic JJ 511 519 proteins protein NNS 520 528 secreted secrete VBN 529 531 by by IN 532 535 LAK LAK NNP 536 541 cells cell NNS 541 542 . . . 543 546 Our our PRP$ 547 551 data datum NNS 552 558 showed show VBD 559 563 that that IN 564 567 TNF TNF NNP 568 578 resistance resistance NN 579 581 in in FW 582 587 vitro vitro FW 588 598 correlates correlate VBZ 599 603 with with IN 604 607 the the DT 608 617 increased increase VBN 618 623 level level NN 624 626 of of IN 627 640 transcription transcription NN 641 647 factor factor NN 648 657 NF-kappaB nf-kappab NN 657 658 . . . 659 663 This this DT 664 671 finding finding NN 672 675 may may MD 676 683 provide provide VB 684 685 a a DT 686 690 tool tool NN 691 693 to to TO 694 701 improve improve VB 702 709 current current JJ 710 719 protocols protocol NNS 720 722 of of IN 723 736 immunotherapy immunotherapy NN 737 740 and and CC 741 749 insights insight NNS 750 752 to to TO 753 756 how how WRB 757 762 tumor tumor NN 763 768 cells cell NNS 769 772 are be VBP 773 775 or or CC 776 779 are be VBP 780 783 not not RB 784 790 killed kill VBN 791 793 by by IN 794 797 LAK LAK NNP 798 803 cells cell NNS 803 804 . . .