0 7 Control Control NNP 8 10 of of IN 11 15 cell cell NN 16 21 cycle cycle NN 22 27 entry entry NN 28 31 and and CC 32 41 apoptosis apoptosis NN 42 44 in in IN 45 46 B B NNP 47 58 lymphocytes lymphocyte NNS 59 67 infected infect VBN 68 70 by by IN 71 83 Epstein-Barr epstein-barr JJ 84 89 virus virus NN 89 90 . . . 92 101 Infection infection NN 102 104 of of IN 105 110 human human JJ 111 112 B B NNP 113 118 cells cell NNS 119 123 with with IN 124 136 Epstein-Barr epstein-barr JJ 137 142 virus virus NN 143 144 ( ( ( 144 147 EBV EBV NNP 147 148 ) ) ) 149 156 results result VBZ 157 159 in in IN 160 170 activation activation NN 171 173 of of IN 174 177 the the DT 178 182 cell cell NN 183 188 cycle cycle NN 189 192 and and CC 193 197 cell cell NN 198 204 growth growth NN 204 205 . . . 206 208 To to TO 209 218 interpret interpret VB 219 222 the the DT 223 233 mechanisms mechanism NNS 234 236 by by IN 237 242 which which WDT 243 246 EBV EBV NNP 247 256 activates activate VBZ 257 260 the the DT 261 265 cell cell NN 265 266 , , , 267 269 we we PRP 270 274 have have VBP 275 282 assayed assay VBN 283 287 many many JJ 288 296 proteins protein NNS 297 305 involved involve VBN 306 308 in in IN 309 316 control control NN 317 319 of of IN 320 323 the the DT 324 326 G0 g0 NN 327 330 and and CC 331 333 G1 g1 NN 334 340 phases phase NNS 341 343 of of IN 344 347 the the DT 348 352 cell cell NN 353 358 cycle cycle NN 359 362 and and CC 363 373 regulation regulation NN 374 376 of of IN 377 386 apoptosis apoptosis NN 386 387 . . . 388 390 In in IN 391 394 EBV EBV NNP 395 404 infection infection NN 405 409 most most JJS 410 412 of of IN 413 416 the the DT 417 424 changes change NNS 424 425 , , , 426 435 including include VBG 436 439 the the DT 440 445 early early JJ 446 455 induction induction NN 456 458 of of IN 459 465 cyclin cyclin NN 466 468 D2 d2 NN 468 469 , , , 470 473 are be VBP 474 483 dependent dependent JJ 484 486 on on IN 487 497 expression expression NN 498 500 of of IN 501 504 EBV EBV NNP 505 510 genes gene NNS 510 511 , , , 512 515 but but CC 516 518 an an DT 519 529 alteration alteration NN 530 532 in in IN 533 536 the the DT 537 542 E2F-4 e2f-4 NN 543 550 profile profile NN 551 554 was be VBD 555 561 partly partly RB 562 573 independent independent JJ 574 576 of of IN 577 582 viral viral JJ 583 587 gene gene NN 588 598 expression expression NN 598 599 , , , 600 610 presumably presumably RB 611 620 occurring occur VBG 621 623 in in IN 624 632 response response NN 633 635 to to TO 636 642 signal signal NN 643 655 transduction transduction NN 656 665 activated activate VBN 666 670 when when WRB 671 674 the the DT 675 680 virus virus NN 681 686 binds bind VBZ 687 689 to to TO 690 693 its its PRP$ 694 702 receptor receptor NN 702 703 , , , 704 708 CD21 CD21 NNP 708 709 . . . 710 712 By by IN 713 722 comparing compare VBG 723 726 the the DT 727 737 expression expression NN 738 740 of of IN 741 746 genes gene NNS 747 758 controlling control VBG 759 768 apoptosis apoptosis NN 768 769 , , , 770 779 including include VBG 780 785 those those DT 786 794 encoding encode VBG 795 802 several several JJ 803 810 members member NNS 811 813 of of IN 814 817 the the DT 818 823 BCL-2 bcl-2 NN 824 830 family family NN 831 833 of of IN 834 842 proteins protein NNS 842 843 , , , 844 847 the the DT 848 853 known known JJ 854 862 relative relative JJ 863 873 resistance resistance NN 874 876 of of IN 877 893 EBV-immortalized ebv-immortalized JJ 894 900 B-cell b-cell NN 901 906 lines line NNS 907 909 to to TO 910 919 apoptosis apoptosis NN 920 927 induced induce VBN 928 930 by by IN 931 934 low low JJ 935 940 serum serum NN 941 944 was be VBD 945 950 found find VBN 951 953 to to TO 954 963 correlate correlate VB 964 968 with with IN 969 979 expression expression NN 980 982 of of IN 983 987 both both CC 988 993 BCL-2 bcl-2 NN 994 997 and and CC 998 1001 A20 A20 NNP 1001 1002 . . . 1003 1006 A20 A20 NNP 1007 1010 can can MD 1011 1013 be be VB 1014 1023 regulated regulate VBN 1024 1026 by by IN 1027 1030 the the DT 1031 1040 NF-kappaB NF-kappaB NNP 1041 1054 transcription transcription NN 1055 1061 factor factor NN 1061 1062 , , , 1063 1068 which which WDT 1069 1071 is be VBZ 1072 1077 known know VBN 1078 1080 to to TO 1081 1083 be be VB 1084 1093 activated activate VBN 1094 1096 by by IN 1097 1100 the the DT 1101 1104 EBV EBV NNP 1105 1110 LMP-1 lmp-1 NN 1111 1118 protein protein NN 1118 1119 . . . 1120 1132 Quantitative quantitative JJ 1133 1139 assays assay NNS 1140 1152 demonstrated demonstrate VBD 1153 1154 a a DT 1155 1161 direct direct JJ 1162 1170 temporal temporal JJ 1171 1183 relationship relationship NN 1184 1191 between between IN 1192 1197 LMP-1 lmp-1 NN 1198 1205 protein protein NN 1206 1212 levels level NNS 1213 1216 and and CC 1217 1223 active active JJ 1224 1233 NF-kappaB nf-kappab NN 1234 1240 during during IN 1241 1244 the the DT 1245 1249 time time NN 1250 1256 course course NN 1257 1259 of of IN 1260 1269 infection infection NN 1269 1270 . . .