0	13	Non-steroidal	non-steroidal	JJ
14	31	anti-inflammatory	anti-inflammatory	JJ
32	37	drugs	drug	NNS
38	45	inhibit	inhibit	VBP
46	49	the	the	DT
50	60	expression	expression	NN
61	63	of	of	IN
64	73	cytokines	cytokine	NNS
74	77	and	and	CC
78	84	induce	induce	VB
85	90	HSP70	hsp70	NN
91	93	in	in	IN
94	99	human	human	JJ
100	109	monocytes	monocyte	NNS
109	110	.	.	.

112	118	Recent	recent	JJ
119	126	studies	study	NNS
127	131	have	have	VBP
132	137	shown	show	VBN
138	142	that	that	IN
143	146	the	the	DT
147	160	non-steroidal	non-steroidal	JJ
161	178	anti-inflammatory	anti-inflammatory	JJ
179	184	drugs	drug	NNS
185	186	(	(	(
186	192	NSAIDs	NSAID	NNPS
192	193	)	)	)
194	202	activate	activate	VBP
203	207	heat	heat	NN
208	213	shock	shock	NN
214	227	transcription	transcription	NN
228	234	factor	factor	NN
235	236	(	(	(
236	240	HSF1	HSF1	NNP
240	241	)	)	)
242	246	from	from	IN
247	248	a	a	DT
249	255	latent	latent	JJ
256	267	cytoplasmic	cytoplasmic	JJ
268	272	form	form	NN
273	275	to	to	TO
276	277	a	a	DT
278	285	nuclear	nuclear	JJ
285	286	,	,	,
287	290	DNA	DNA	NNP
291	298	binding	binding	NN
299	304	state	state	NN
304	305	.	.	.

306	308	As	as	IN
309	313	HSF1	HSF1	NNP
314	317	can	can	MD
318	326	function	function	VB
327	329	as	as	IN
330	334	both	both	CC
335	337	an	an	DT
338	347	activator	activator	NN
348	350	of	of	IN
351	355	heat	heat	NN
356	361	shock	shock	NN
362	367	genes	gene	NNS
368	371	and	and	CC
372	373	a	a	DT
374	383	repressor	repressor	NN
384	386	of	of	IN
387	395	non-heat	non-heat	JJ
396	401	shock	shock	NN
402	407	genes	gene	NNS
408	412	such	such	JJ
413	415	as	as	IN
416	420	IL1B	IL1B	NNP
421	424	and	and	CC
425	427	c-	c-	NN
428	431	fos	fo	NNS
431	432	,	,	,
433	435	we	we	PRP
436	440	have	have	VBP
441	449	examined	examine	VBN
450	453	the	the	DT
454	463	potential	potential	JJ
464	468	role	role	NN
469	471	of	of	IN
472	476	HSF1	hsf1	NN
477	479	in	in	IN
480	483	the	the	DT
484	491	effects	effect	NNS
492	494	of	of	IN
495	501	NSAIDs	nsaid	NNS
502	504	on	on	IN
505	509	gene	gene	NN
510	520	expression	expression	NN
521	523	in	in	IN
524	525	a	a	DT
526	531	human	human	JJ
532	541	monocytic	monocytic	JJ
542	546	cell	cell	NN
547	551	line	line	NN
552	557	THP-1	thp-1	NN
557	558	.	.	.

559	561	We	we	PRP
562	567	found	find	VBD
568	572	that	that	IN
573	576	two	two	CD
577	584	members	member	NNS
585	587	of	of	IN
588	591	the	the	DT
592	598	NSAIDs	NSAID	NNP
598	599	,	,	,
600	606	sodium	sodium	NN
607	617	salicylate	salicylate	NN
618	621	and	and	CC
622	630	sulindac	sulindac	NN
631	638	repress	repress	VBP
639	642	the	the	DT
643	647	IL1B	il1b	NN
648	656	promoter	promoter	NN
657	659	to	to	TO
660	667	similar	similar	JJ
668	674	degree	degree	NN
675	677	to	to	TO
678	682	heat	heat	NN
683	688	shock	shock	NN
689	691	or	or	CC
692	696	HSF1	hsf1	NN
697	711	overexpression	overexpression	NN
711	712	.	.	.

713	715	In	in	IN
716	724	addition	addition	NN
724	725	,	,	,
726	732	sodium	sodium	NN
733	743	salicylate	salicylate	NN
744	747	and	and	CC
748	758	additional	additional	JJ
759	765	NSAIDs	nsaid	NNS
766	770	used	use	VBN
771	773	at	at	IN
774	788	concentrations	concentration	NNS
789	793	that	that	WDT
794	802	activate	activate	VBP
803	807	HSF1	hsf1	NN
808	812	also	also	RB
813	822	inhibited	inhibit	VBD
823	826	the	the	DT
827	837	expression	expression	NN
838	840	of	of	IN
841	846	other	other	JJ
847	856	monocytic	monocytic	JJ
857	862	genes	gene	NNS
863	864	(	(	(
864	873	TNF-alpha	TNF-alpha	NNP
873	874	,	,	,
875	883	IL-1beta	IL-1beta	NNP
883	884	,	,	,
885	889	IL-6	IL-6	NNP
889	890	,	,	,
891	895	IL-8	IL-8	NNP
895	896	,	,	,
897	902	IL-10	IL-10	NNP
902	903	,	,	,
904	910	ICAM-1	ICAM-1	NNP
910	911	)	)	)
912	921	activated	activate	VBN
922	924	by	by	IN
925	933	exposure	exposure	NN
934	936	to	to	TO
937	938	a	a	DT
939	955	pro-inflammatory	pro-inflammatory	JJ
956	964	stimulus	stimulus	NN
965	966	(	(	(
966	984	lipopolysaccharide	lipopolysaccharide	NN
984	985	,	,	,
986	989	LPS	LPS	NNP
989	990	)	)	)
990	991	.	.	.

992	994	At	at	IN
995	1000	least	least	JJS
1001	1003	in	in	IN
1004	1007	the	the	DT
1008	1012	case	case	NN
1013	1015	of	of	IN
1016	1019	the	the	DT
1020	1024	IL1B	IL1B	NNP
1025	1033	promoter	promoter	NN
1033	1034	,	,	,
1035	1045	repression	repression	NN
1046	1049	did	do	VBD
1050	1053	not	not	RB
1054	1058	seem	seem	VB
1059	1061	to	to	TO
1062	1069	involve	involve	VB
1070	1077	another	another	DT
1078	1084	factor	factor	NN
1085	1090	whose	whose	WP$
1091	1099	activity	activity	NN
1100	1102	is	be	VBZ
1103	1111	affected	affect	VBN
1112	1114	by	by	IN
1115	1118	the	the	DT
1119	1125	NSAIDs	NSAID	NNP
1125	1126	,	,	,
1127	1135	NFkappaB	NFkappaB	NNP
1136	1138	as	as	IN
1139	1142	the	the	DT
1143	1147	IL1B	IL1B	NNP
1148	1156	promoter	promoter	NN
1157	1165	fragment	fragment	NN
1166	1170	used	use	VBN
1171	1173	in	in	IN
1174	1177	our	our	PRP$
1178	1185	studies	study	NNS
1186	1188	is	be	VBZ
1189	1192	not	not	RB
1193	1201	NFkappaB	nfkappab	NN
1202	1212	responsive	responsive	JJ
1213	1216	and	and	CC
1217	1222	binds	bind	VBZ
1223	1235	specifically	specifically	RB
1236	1238	to	to	TO
1239	1243	HSF1	hsf1	NN
1243	1244	.	.	.

1245	1253	Exposure	exposure	NN
1254	1256	to	to	TO
1257	1263	NSAIDs	NSAID	NNP
1264	1267	had	have	VBD
1268	1269	a	a	DT
1270	1277	complex	complex	JJ
1278	1284	effect	effect	NN
1285	1287	on	on	IN
1288	1291	HSP	HSP	NNP
1292	1296	gene	gene	NN
1297	1307	expression	expression	NN
1308	1311	and	and	CC
1312	1317	while	while	IN
1318	1326	sulindac	sulindac	NN
1327	1336	activated	activate	VBD
1337	1340	the	the	DT
1341	1347	stress	stress	NN
1348	1358	responsive	responsive	JJ
1359	1365	HSP70B	HSP70B	NNP
1366	1374	promoter	promoter	NN
1374	1375	,	,	,
1376	1382	sodium	sodium	NN
1383	1393	salicylate	salicylate	NN
1394	1397	did	do	VBD
1398	1401	not	not	RB
1401	1402	.	.	.

1403	1405	In	in	IN
1406	1414	addition	addition	NN
1414	1415	,	,	,
1416	1420	only	only	RB
1421	1422	a	a	DT
1423	1429	subset	subset	NN
1430	1432	of	of	IN
1433	1436	the	the	DT
1437	1443	NSAIDs	NSAID	NNPS
1444	1451	induced	induce	VBD
1452	1457	HSP70	HSP70	NNP
1458	1462	mRNA	mrna	NN
1463	1470	species	specie	NNS
1470	1471	.	.	.

1472	1477	These	these	DT
1478	1486	findings	finding	NNS
1487	1494	reflect	reflect	VBP
1495	1498	the	the	DT
1499	1509	properties	property	NNS
1510	1512	of	of	IN
1513	1517	HSF1	hsf1	NN
1518	1523	which	which	WDT
1524	1527	can	can	MD
1528	1530	be	be	VB
1531	1540	activated	activate	VBN
1541	1543	to	to	TO
1544	1546	at	at	IN
1547	1552	least	least	JJS
1553	1556	two	two	CD
1557	1560	DNA	dna	NN
1561	1568	binding	binding	NN
1569	1574	forms	form	NNS
1575	1579	only	only	RB
1580	1583	one	one	CD
1584	1586	of	of	IN
1587	1592	which	which	WDT
1593	1602	activates	activate	VBZ
1603	1607	heat	heat	NN
1608	1613	shock	shock	NN
1614	1623	promoters	promoter	NNS
1624	1627	and	and	CC
1628	1635	suggest	suggest	VBP
1636	1640	that	that	IN
1641	1651	individual	individual	JJ
1652	1657	NSAID	nsaid	NN
1658	1664	family	family	NN
1665	1672	members	member	NNS
1673	1676	may	may	MD
1677	1691	differentially	differentially	RB
1692	1698	induce	induce	VB
1699	1702	one	one	CD
1703	1705	or	or	CC
1706	1711	other	other	JJ
1712	1714	of	of	IN
1715	1720	these	these	DT
1721	1726	forms	form	NNS
1726	1727	.	.	.

1728	1735	Overall	overall	RB
1736	1745	therefore	therefore	RB
1745	1746	,	,	,
1747	1755	exposure	exposure	NN
1756	1758	to	to	TO
1759	1765	NSAIDs	NSAID	NNP
1766	1771	leads	lead	VBZ
1772	1774	to	to	TO
1775	1776	a	a	DT
1777	1785	profound	profound	JJ
1786	1792	switch	switch	NN
1793	1795	in	in	IN
1796	1800	gene	gene	NN
1801	1811	expression	expression	NN
1812	1814	in	in	IN
1815	1824	monocytic	monocytic	JJ
1825	1830	cells	cell	NNS
1830	1831	,	,	,
1832	1836	with	with	IN
1837	1848	suppression	suppression	NN
1849	1851	of	of	IN
1852	1857	genes	gene	NNS
1858	1866	involved	involve	VBN
1867	1869	in	in	IN
1870	1880	macrophage	macrophage	NN
1881	1891	activation	activation	NN
1892	1895	and	and	CC
1896	1905	induction	induction	NN
1906	1908	of	of	IN
1909	1915	stress	stress	NN
1916	1921	genes	gene	NNS
1922	1925	and	and	CC
1926	1930	HSF1	hsf1	NN
1931	1938	appears	appear	VBZ
1939	1941	to	to	TO
1942	1946	play	play	VB
1947	1948	a	a	DT
1949	1959	regulatory	regulatory	JJ
1960	1964	role	role	NN
1965	1967	in	in	IN
1968	1973	these	these	DT
1974	1981	effects	effect	NNS
1981	1982	.	.	.

1983	1992	Copyright	Copyright	NNP
1993	1997	1999	1999	CD
1998	2006	Academic	Academic	NNP
2007	2012	Press	Press	NNP
2012	2013	.	.	.