0 10 Repression repression NN 11 13 by by IN 14 20 Ikaros Ikaros NNP 21 24 and and CC 25 31 Aiolos Aiolos NNP 32 34 is be VBZ 35 43 mediated mediate VBN 44 51 through through IN 52 59 histone histone NN 60 71 deacetylase deacetylase NN 72 81 complexes complex NNS 81 82 . . . 84 88 Here here RB 89 91 we we PRP 92 96 show show VBP 97 101 that that IN 102 105 the the DT 106 114 lymphoid lymphoid JJ 115 134 lineage-determining lineage-determining JJ 135 142 factors factor NNS 143 149 Ikaros Ikaros NNP 150 153 and and CC 154 160 Aiolos Aiolos NNP 161 164 can can MD 165 173 function function VB 174 176 as as IN 177 183 strong strong JJ 184 199 transcriptional transcriptional JJ 200 210 repressors repressor NNS 210 211 . . . 212 216 This this DT 217 225 function function NN 226 228 is be VBZ 229 237 mediated mediate VBN 238 245 through through IN 246 249 two two CD 250 260 repression repression NN 261 268 domains domain NNS 269 272 and and CC 273 275 is be VBZ 276 285 dependent dependent JJ 286 290 upon upon IN 291 294 the the DT 295 303 promoter promoter NN 304 311 context context NN 312 315 and and CC 316 320 cell cell NN 321 325 type type NN 325 326 . . . 327 337 Repression repression NN 338 340 by by IN 341 347 Ikaros Ikaros NNP 348 356 proteins protein NNS 357 367 correlates correlate VBZ 368 372 with with IN 373 389 hypo-acetylation hypo-acetylation NN 390 392 of of IN 393 397 core core NN 398 406 histones histone NNS 407 409 at at IN 410 418 promoter promoter NN 419 424 sites site NNS 425 428 and and CC 429 431 is be VBZ 432 440 relieved relieve VBN 441 443 by by IN 444 451 histone histone NN 452 463 deacetylase deacetylase NN 464 474 inhibitors inhibitor NNS 474 475 . . . 476 486 Consistent consistent JJ 487 491 with with IN 492 497 these these DT 498 506 findings finding NNS 506 507 , , , 508 514 Ikaros Ikaros NNP 515 518 and and CC 519 522 its its PRP$ 523 533 repression repression NN 534 541 domains domain NNS 542 545 can can MD 546 554 interact interact VB 555 557 in in FW 558 562 vivo vivo FW 563 566 and and CC 567 569 in in FW 570 575 vitro vitro FW 576 580 with with IN 581 584 the the DT 585 590 mSin3 msin3 NN 591 597 family family NN 598 600 of of IN 601 614 co-repressors co-repressor NNS 615 620 which which WDT 621 625 bind bind VBP 626 628 to to TO 629 636 histone histone NN 637 649 deacetylases deacetylas NNS 649 650 . . . 651 656 Based base VBN 657 659 on on IN 660 665 these these DT 666 669 and and CC 670 673 our our PRP$ 674 680 recent recent JJ 681 689 findings finding NNS 690 692 of of IN 693 705 associations association NNS 706 713 between between IN 714 720 Ikaros Ikaros NNP 721 724 and and CC 725 734 Mi-2-HDAC Mi-2-HDAC NNP 734 735 , , , 736 738 we we PRP 739 746 propose propose VBP 747 751 that that IN 752 758 Ikaros Ikaros NNP 759 765 family family NN 766 773 members member NNS 774 782 modulate modulate VBP 783 787 gene gene NN 788 798 expression expression NN 799 805 during during IN 806 816 lymphocyte lymphocyte NN 817 828 development development NN 829 831 by by IN 832 842 recruiting recruit VBG 843 851 distinct distinct JJ 852 859 histone histone NN 860 871 deacetylase deacetylase NN 872 881 complexes complex NNS 882 884 to to TO 885 893 specific specific JJ 894 903 promoters promoter NNS 903 904 . . .