0 15 Transcriptional transcriptional JJ 16 26 regulation regulation NN 27 29 of of IN 30 31 T t NN 32 42 lymphocyte lymphocyte NN 43 54 development development NN 55 58 and and CC 59 67 function function NN 67 68 . . . 70 73 The the DT 74 85 development development NN 86 89 and and CC 90 98 function function NN 99 101 of of IN 102 103 T t NN 104 115 lymphocytes lymphocyte NNS 116 119 are be VBP 120 129 regulated regulate VBN 130 137 tightly tightly RB 138 140 by by IN 141 147 signal signal NN 148 160 transduction transduction NN 161 169 pathways pathway NNS 170 174 that that WDT 175 182 include include VBP 183 191 specific specific JJ 192 204 cell-surface cell-surface JJ 205 214 receptors receptor NNS 214 215 , , , 216 229 intracellular intracellular JJ 230 239 signaling signal VBG 240 249 molecules molecule NNS 249 250 , , , 251 254 and and CC 255 262 nuclear nuclear JJ 263 276 transcription transcription NN 277 284 factors factor NNS 284 285 . . . 286 291 Since since IN 292 296 1988 1988 CD 296 297 , , , 298 305 several several JJ 306 314 families family NNS 315 317 of of IN 318 330 functionally functionally RB 331 340 important important JJ 341 342 T t NN 343 347 cell cell NN 348 361 transcription transcription NN 362 369 factors factor NNS 370 374 have have VBP 375 379 been be VBN 380 390 identified identify VBN 390 391 . . . 392 397 These these DT 398 405 include include VBP 406 409 the the DT 410 416 Ikaros Ikaros NNP 416 417 , , , 418 422 LKLF LKLF NNP 422 423 , , , 424 427 and and CC 428 433 GATA3 gata3 NN 434 445 zinc-finger zinc-finger JJ 446 454 proteins protein NNS 454 455 ; ; : 456 459 the the DT 460 463 Ets Ets NNPS 463 464 , , , 465 473 CREB/ATF CREB/ATF NNP 473 474 , , , 475 478 and and CC 479 487 NF-kappa NF-kappa NNP 488 498 B/Rel/NFAT B/Rel/NFAT NNP 499 512 transcription transcription NN 513 520 factors factor NNS 520 521 ; ; : 522 525 the the DT 526 530 Stat Stat NNP 531 539 proteins protein NNS 539 540 ; ; : 541 544 and and CC 545 548 HMG HMG NNP 549 552 box box NN 553 566 transcription transcription NN 567 574 factors factor NNS 575 579 such such JJ 580 582 as as IN 583 587 LEF1 LEF1 NNP 587 588 , , , 589 593 TCF1 TCF1 NNP 593 594 , , , 595 598 and and CC 599 603 Sox4 sox4 NN 603 604 . . . 605 607 In in IN 608 612 this this DT 613 619 review review NN 619 620 , , , 621 623 we we PRP 624 633 summarize summarize VBP 634 637 our our PRP$ 638 645 current current JJ 646 659 understanding understanding NN 660 662 of of IN 663 666 the the DT 667 682 transcriptional transcriptional JJ 683 693 regulation regulation NN 694 696 of of IN 697 698 T t NN 699 703 cell cell NN 704 715 development development NN 716 719 and and CC 720 728 function function NN 729 733 with with IN 734 744 particular particular JJ 745 753 emphasis emphasis NN 754 756 on on IN 757 760 the the DT 761 768 results result NNS 769 771 of of IN 772 778 recent recent JJ 779 783 gene gene NN 784 793 targeting targeting NN 794 797 and and CC 798 808 transgenic transgenic JJ 809 820 experiments experiment NNS 820 821 . . . 822 824 In in IN 825 833 addition addition NN 834 836 to to TO 837 847 increasing increase VBG 848 851 our our PRP$ 852 865 understanding understanding NN 866 868 of of IN 869 872 the the DT 873 882 molecular molecular JJ 883 891 pathways pathway NNS 892 896 that that WDT 897 905 regulate regulate VBP 906 907 T t NN 908 912 cell cell NN 913 924 development development NN 925 928 and and CC 929 937 function function NN 937 938 , , , 939 944 these these DT 945 952 results result NNS 953 957 have have VBP 958 967 suggested suggest VBN 968 973 novel novel JJ 974 981 targets target NNS 982 985 for for IN 986 993 genetic genetic JJ 994 997 and and CC 998 1013 pharmacological pharmacological JJ 1014 1026 manipulation manipulation NN 1027 1029 of of IN 1030 1031 T t NN 1032 1036 cell cell NN 1037 1045 immunity immunity NN 1045 1046 . . .