0 9 PPARgamma PPARgamma NNP 10 20 activation activation NN 21 28 induces induce VBZ 29 32 the the DT 33 43 expression expression NN 44 46 of of IN 47 50 the the DT 51 60 adipocyte adipocyte NN 61 66 fatty fatty JJ 67 71 acid acid NN 72 79 binding binding NN 80 87 protein protein NN 88 92 gene gene NN 93 95 in in IN 96 101 human human JJ 102 111 monocytes monocyte NNS 111 112 . . . 114 117 The the DT 118 141 peroxisome-proliferator peroxisome-proliferator NN 142 151 activated activated JJ 152 160 receptor receptor NN 161 166 gamma gamma NN 167 168 ( ( ( 168 177 PPARgamma PPARgamma NNP 177 178 ) ) ) 178 179 , , , 180 181 a a DT 182 188 member member NN 189 191 of of IN 192 195 the the DT 196 203 nuclear nuclear JJ 204 212 receptor receptor NN 213 224 superfamily superfamily NN 225 227 of of IN 228 234 ligand ligand NN 235 244 activated activate VBD 245 258 transcription transcription NN 259 266 factors factor NNS 266 267 , , , 268 273 plays play VBZ 274 275 a a DT 276 279 key key JJ 280 284 role role NN 285 287 in in IN 288 291 the the DT 292 305 anti-diabetic anti-diabetic JJ 306 313 actions action NNS 314 316 of of IN 317 320 the the DT 321 339 thiazolidinediones thiazolidinedione NNS 340 341 ( ( ( 341 345 TZDs TZD NNP 345 346 ) ) ) 346 347 . . . 348 357 PPARgamma PPARgamma NNP 358 365 induces induce VBZ 366 369 the the DT 370 380 expression expression NN 381 383 of of IN 384 388 many many JJ 389 394 genes gene NNS 395 403 involved involve VBN 404 406 in in IN 407 412 lipid lipid NN 413 422 anabolism anabolism NN 422 423 , , , 424 433 including include VBG 434 437 the the DT 438 447 adipocyte adipocyte NN 448 453 fatty fatty JJ 454 458 acid acid NN 459 466 binding binding NN 467 474 protein protein NN 475 476 ( ( ( 476 479 aP2 ap2 NN 479 480 ) ) ) 480 481 , , , 482 485 and and CC 486 488 is be VBZ 489 490 a a DT 491 494 key key JJ 495 504 regulator regulator NN 505 507 of of IN 508 517 adipocyte adipocyte NN 518 533 differentiation differentiation NN 533 534 . . . 535 544 PPARgamma PPARgamma NNP 545 547 is be VBZ 548 552 also also RB 553 562 expressed express VBN 563 565 in in IN 566 579 hematopoietic hematopoietic JJ 580 585 cells cell NNS 586 589 and and CC 590 592 is be VBZ 593 605 up-regulated up-regulate VBN 606 608 in in IN 609 618 activated activate VBN 619 640 monocytes/macrophages monocytes/macrophage NNS 640 641 . . . 642 652 Activation Activation NNP 653 655 of of IN 656 665 PPARgamma PPARgamma NNP 666 669 may may MD 670 674 play play VB 675 676 a a DT 677 681 role role NN 682 684 in in IN 685 688 the the DT 689 698 induction induction NN 699 701 of of IN 702 717 differentiation differentiation NN 718 720 of of IN 721 732 macrophages macrophage NNS 733 735 to to TO 736 740 foam foam NN 741 746 cells cell NNS 747 751 that that WDT 752 755 are be VBP 756 766 associated associate VBN 767 771 with with IN 772 787 atherosclerotic atherosclerotic JJ 788 795 lesions lesion NNS 795 796 . . . 797 799 We we PRP 800 806 report report VBP 807 811 that that IN 812 816 both both CC 817 824 natural natural JJ 825 828 and and CC 829 838 synthetic synthetic JJ 839 848 PPARgamma PPARgamma NNP 849 857 agonists agonist NNS 858 864 induce induce VBP 865 870 time- time- NN 871 874 and and CC 875 889 dose-dependent dose-dependent JJ 890 899 increases increase NNS 900 902 in in IN 903 906 aP2 ap2 NN 907 911 mRNA mrna NN 912 914 in in IN 915 919 both both CC 920 927 primary primary JJ 928 933 human human JJ 934 943 monocytes monocyte NNS 944 947 and and CC 948 951 the the DT 952 961 monocytic monocytic JJ 962 966 cell cell NN 967 971 line line NN 971 972 , , , 973 978 THP-1 thp-1 NN 978 979 . . . 980 985 These these DT 986 990 data datum NNS 991 998 suggest suggest VBP 999 1003 that that IN 1004 1013 PPARgamma PPARgamma NNP 1014 1024 activation activation NN 1025 1028 may may MD 1029 1033 play play VB 1034 1035 a a DT 1036 1040 role role NN 1041 1043 in in IN 1044 1052 monocyte monocyte NN 1053 1068 differentiation differentiation NN 1069 1072 and and CC 1073 1081 function function NN 1082 1091 analogous analogous JJ 1092 1094 to to TO 1095 1098 its its PRP$ 1099 1117 well-characterized well-characterized JJ 1118 1122 role role NN 1123 1125 in in IN 1126 1136 adipocytes adipocyte NNS 1136 1137 . . .