0 18 NF-kappaB-mediated nf-kappab-mediated JJ 19 32 up-regulation up-regulation NN 33 35 of of IN 36 41 Bcl-x Bcl-x NNP 42 45 and and CC 46 54 Bfl-1/A1 Bfl-1/A1 NNP 55 57 is be VBZ 58 66 required require VBN 67 70 for for IN 71 75 CD40 CD40 NNP 76 84 survival survival NN 85 94 signaling signaling NN 95 97 in in IN 98 99 B B NNP 100 111 lymphocytes lymphocyte NNS 111 112 . . . 114 124 Activation Activation NNP 125 127 of of IN 128 132 CD40 CD40 NNP 133 135 is be VBZ 136 145 essential essential JJ 146 149 for for IN 150 166 thymus-dependent thymus-dependent JJ 167 174 humoral humoral JJ 175 181 immune immune JJ 182 191 responses response NNS 192 195 and and CC 196 204 rescuing rescue VBG 205 206 B B NNP 207 212 cells cell NNS 213 217 from from IN 218 227 apoptosis apoptosis NN 227 228 . . . 229 233 Many many JJ 234 236 of of IN 237 240 the the DT 241 248 effects effect NNS 249 251 of of IN 252 256 CD40 CD40 NNP 257 260 are be VBP 261 269 believed believe VBN 270 272 to to TO 273 275 be be VB 276 284 achieved achieve VBN 285 292 through through IN 293 300 altered alter VBN 301 305 gene gene NN 306 316 expression expression NN 316 317 . . . 318 320 In in IN 321 329 addition addition NN 330 332 to to TO 333 338 Bcl-x Bcl-x NNP 338 339 , , , 340 341 a a DT 342 347 known known JJ 348 362 CD40-regulated cd40-regulated JJ 363 376 antiapoptotic antiapoptotic JJ 377 385 molecule molecule NN 385 386 , , , 387 389 we we PRP 390 400 identified identify VBD 401 402 a a DT 403 410 related related JJ 411 424 antiapoptotic antiapoptotic JJ 425 433 molecule molecule NN 433 434 , , , 435 443 A1/Bfl-1 A1/Bfl-1 NNP 443 444 , , , 445 447 as as IN 448 449 a a DT 450 464 CD40-inducible cd40-inducible JJ 465 469 gene gene NN 469 470 . . . 471 481 Inhibition Inhibition NNP 482 484 of of IN 485 488 the the DT 489 498 NF-kappaB NF-kappaB NNP 499 506 pathway pathway NN 507 509 by by IN 510 524 overexpression overexpression NN 525 527 of of IN 528 529 a a DT 530 545 dominant-active dominant-active JJ 546 555 inhibitor inhibitor NN 556 558 of of IN 559 568 NF-kappaB NF-kappaB NNP 569 578 abolished abolish VBD 579 591 CD40-induced cd40-induced JJ 592 605 up-regulation up-regulation NN 606 608 of of IN 609 613 both both CC 614 617 the the DT 618 623 Bfl-1 bfl-1 NN 624 627 and and CC 628 633 Bcl-x Bcl-x NNP 634 639 genes gene NNS 640 643 and and CC 644 648 also also RB 649 659 eliminated eliminate VBD 660 663 the the DT 664 671 ability ability NN 672 674 of of IN 675 679 CD40 CD40 NNP 680 682 to to TO 683 689 rescue rescue VB 690 701 Fas-induced fas-induced JJ 702 706 cell cell NN 707 712 death death NN 712 713 . . . 714 720 Within within IN 721 724 the the DT 725 733 upstream upstream JJ 734 742 promoter promoter NN 743 749 region region NN 750 752 of of IN 753 758 Bcl-x Bcl-x NNP 758 759 , , , 760 761 a a DT 762 771 potential potential JJ 772 789 NF-kappaB-binding nf-kappab-binding JJ 790 798 sequence sequence NN 799 802 was be VBD 803 808 found find VBN 809 811 to to TO 812 819 support support VB 820 839 NF-kappaB-dependent nf-kappab-dependent JJ 840 855 transcriptional transcriptional JJ 856 866 activation activation NN 866 867 . . . 868 879 Furthermore furthermore RB 879 880 , , , 881 891 expression expression NN 892 894 of of IN 895 908 physiological physiological JJ 909 915 levels level NNS 916 918 of of IN 919 924 Bcl-x Bcl-x NNP 925 934 protected protect VBD 935 936 B B NNP 937 942 cells cell NNS 943 947 from from IN 948 960 Fas-mediated fas-mediated JJ 961 970 apoptosis apoptosis NN 971 973 in in IN 974 977 the the DT 978 985 absence absence NN 986 988 of of IN 989 998 NF-kappaB NF-kappaB NNP 999 1008 signaling signaling NN 1008 1009 . . . 1010 1014 Thus thus RB 1014 1015 , , , 1016 1019 our our PRP$ 1020 1027 results result NNS 1028 1035 suggest suggest VBP 1036 1040 that that IN 1041 1054 CD40-mediated cd40-mediated JJ 1055 1059 cell cell NN 1060 1068 survival survival NN 1069 1077 proceeds proceed VBZ 1078 1085 through through IN 1086 1105 NF-kappaB-dependent nf-kappab-dependent JJ 1106 1119 up-regulation up-regulation NN 1120 1122 of of IN 1123 1128 Bcl-2 bcl-2 NN 1129 1135 family family NN 1136 1143 members member NNS 1143 1144 . . .