0 11 Distinctive distinctive JJ 12 16 gene gene NN 17 27 expression expression NN 28 36 patterns pattern NNS 37 39 in in IN 40 45 human human JJ 46 53 mammary mammary JJ 54 64 epithelial epithelial JJ 65 70 cells cell NNS 71 74 and and CC 75 81 breast breast NN 82 90 cancers. cancers. NN 92 96 cDNA cdna NN 97 108 microarrays microarray NNS 109 112 and and CC 113 114 a a DT 115 125 clustering clustering NN 126 135 algorithm algorithm NN 136 140 were be VBD 141 145 used use VBN 146 148 to to TO 149 157 identify identify VB 158 166 patterns pattern NNS 167 169 of of IN 170 174 gene gene NN 175 185 expression expression NN 186 188 in in IN 189 194 human human JJ 195 202 mammary mammary JJ 203 213 epithelial epithelial JJ 214 219 cells cell NNS 220 227 growing grow VBG 228 230 in in IN 231 238 culture culture NN 239 242 and and CC 243 245 in in IN 246 253 primary primary JJ 254 259 human human JJ 260 266 breast breast NN 267 273 tumors tumor NNS 273 274 . . . 275 283 Clusters cluster NNS 284 286 of of IN 287 298 coexpressed coexpresse VBN 299 304 genes gene NNS 305 315 identified identify VBN 316 323 through through IN 324 337 manipulations manipulation NNS 338 340 of of IN 341 348 mammary mammary JJ 349 359 epithelial epithelial JJ 360 365 cells cell NNS 366 368 in in FW 369 374 vitro vitro FW 375 379 also also RB 380 386 showed show VBD 387 397 consistent consistent JJ 398 406 patterns pattern NNS 407 409 of of IN 410 419 variation variation NN 420 422 in in IN 423 433 expression expression NN 434 439 among among IN 440 446 breast breast NN 447 452 tumor tumor NN 453 460 samples sample NNS 460 461 . . . 462 464 By by IN 465 470 using use VBG 471 491 immunohistochemistry immunohistochemistry NN 492 496 with with IN 497 507 antibodies antibody NNS 508 515 against against IN 516 524 proteins protein NNS 525 532 encoded encode VBN 533 535 by by IN 536 537 a a DT 538 548 particular particular JJ 549 553 gene gene NN 554 556 in in IN 557 558 a a DT 559 566 cluster cluster NN 566 567 , , , 568 571 the the DT 572 580 identity identity NN 581 583 of of IN 584 587 the the DT 588 592 cell cell NN 593 597 type type NN 598 604 within within IN 605 608 the the DT 609 614 tumor tumor NN 615 623 specimen specimen NN 624 628 that that WDT 629 640 contributed contribute VBD 641 644 the the DT 645 653 observed observe VBN 654 658 gene gene NN 659 669 expression expression NN 670 677 pattern pattern NN 678 683 could could MD 684 686 be be VB 687 697 determined determine VBN 697 698 . . . 699 707 Clusters cluster NNS 708 710 of of IN 711 716 genes gene NNS 717 721 with with IN 722 730 coherent coherent JJ 731 741 expression expression NN 742 750 patterns pattern NNS 751 753 in in IN 754 762 cultured culture VBN 763 768 cells cell NNS 769 772 and and CC 773 775 in in IN 776 779 the the DT 780 786 breast breast NN 787 793 tumors tumor NNS 794 801 samples sample NNS 802 807 could could MD 808 810 be be VB 811 818 related related JJ 819 821 to to TO 822 830 specific specific JJ 831 839 features feature NNS 840 842 of of IN 843 853 biological biological JJ 854 863 variation variation NN 864 869 among among IN 870 873 the the DT 874 881 samples sample NNS 881 882 . . . 883 886 Two two CD 887 891 such such JJ 892 900 clusters cluster NNS 901 905 were be VBD 906 911 found find VBN 912 914 to to TO 915 919 have have VB 920 928 patterns pattern NNS 929 933 that that WDT 934 944 correlated correlate VBD 945 949 with with IN 950 959 variation variation NN 960 962 in in IN 963 967 cell cell NN 968 981 proliferation proliferation NN 982 987 rates rate NNS 988 991 and and CC 992 996 with with IN 997 1007 activation activation NN 1008 1010 of of IN 1011 1014 the the DT 1015 1028 IFN-regulated ifn-regulated JJ 1029 1035 signal signal NN 1036 1048 transduction transduction NN 1049 1056 pathway pathway NN 1056 1057 , , , 1058 1070 respectively respectively RB 1070 1071 . . . 1072 1080 Clusters cluster NNS 1081 1083 of of IN 1084 1089 genes gene NNS 1090 1099 expressed express VBN 1100 1102 by by IN 1103 1110 stromal stromal JJ 1111 1116 cells cell NNS 1117 1120 and and CC 1121 1132 lymphocytes lymphocyte NNS 1133 1135 in in IN 1136 1139 the the DT 1140 1146 breast breast NN 1147 1153 tumors tumor NNS 1154 1158 also also RB 1159 1163 were be VBD 1164 1174 identified identify VBN 1175 1177 in in IN 1178 1182 this this DT 1183 1191 analysis analysis NN 1191 1192 . . . 1193 1198 These these DT 1199 1206 results result NNS 1207 1214 support support VBP 1215 1218 the the DT 1219 1230 feasibility feasibility NN 1231 1234 and and CC 1235 1245 usefulness usefulness NN 1246 1248 of of IN 1249 1253 this this DT 1254 1264 systematic systematic JJ 1265 1273 approach approach NN 1274 1276 to to TO 1277 1285 studying study VBG 1286 1295 variation variation NN 1296 1298 in in IN 1299 1303 gene gene NN 1304 1314 expression expression NN 1315 1323 patterns pattern NNS 1324 1326 in in IN 1327 1332 human human JJ 1333 1340 cancers cancer NNS 1341 1343 as as IN 1344 1345 a a DT 1346 1351 means means NN 1352 1354 to to TO 1355 1362 dissect dissect VB 1363 1366 and and CC 1367 1375 classify classify VB 1376 1381 solid solid JJ 1382 1388 tumors tumor NNS 1388 1389 . . .