0	10	Neutrophil	Neutrophil	NNP
11	21	maturation	maturation	NN
22	25	and	and	CC
26	29	the	the	DT
30	34	role	role	NN
35	37	of	of	IN
38	46	retinoic	retinoic	JJ
47	51	acid	acid	NN
51	52	.	.	.

54	64	Neutrophil	Neutrophil	NNP
65	75	maturation	maturation	NN
76	82	occurs	occur	VBZ
83	85	in	in	IN
86	90	well	well	RB
91	98	defined	define	VBN
99	112	morphological	morphological	JJ
113	119	stages	stage	NNS
120	124	that	that	WDT
125	134	correlate	correlate	VBP
135	139	with	with	IN
140	143	the	the	DT
144	155	acquisition	acquisition	NN
156	158	of	of	IN
159	168	molecular	molecular	JJ
169	176	markers	marker	NNS
177	187	associated	associate	VBN
188	192	with	with	IN
193	203	neutrophil	neutrophil	NN
204	212	function	function	NN
212	213	.	.	.

214	215	A	a	DT
216	223	variety	variety	NN
224	226	of	of	IN
227	234	factors	factor	NNS
235	238	are	be	VBP
239	244	known	know	VBN
245	247	to	to	TO
248	252	play	play	VB
253	254	a	a	DT
255	259	role	role	NN
260	262	in	in	IN
263	271	terminal	terminal	JJ
272	282	neutrophil	neutrophil	NN
283	293	maturation	maturation	NN
293	294	,	,	,
295	304	including	include	VBG
305	308	the	the	DT
309	316	vitamin	vitamin	NN
317	318	A	a	NN
319	329	derivative	derivative	NN
329	330	,	,	,
331	339	retinoic	retinoic	JJ
340	344	acid	acid	NN
344	345	.	.	.

346	354	Retinoic	retinoic	JJ
355	359	acid	acid	NN
360	363	can	can	MD
364	372	directly	directly	RB
373	381	modulate	modulate	VB
382	386	gene	gene	NN
387	397	expression	expression	NN
398	401	via	via	IN
402	409	binding	bind	VBG
410	412	to	to	TO
413	416	its	its	PRP$
417	424	nuclear	nuclear	JJ
425	434	receptors	receptor	NNS
434	435	,	,	,
436	441	which	which	WDT
442	445	can	can	MD
445	446	,	,	,
447	449	in	in	IN
450	454	turn	turn	NN
454	455	,	,	,
456	464	activate	activate	VBP
465	478	transcription	transcription	NN
479	481	of	of	IN
482	488	target	target	NN
489	494	genes	gene	NNS
494	495	.	.	.

496	497	A	a	DT
498	502	role	role	NN
503	506	for	for	IN
507	515	retinoic	retinoic	JJ
516	520	acid	acid	NN
521	527	during	during	IN
528	538	neutrophil	neutrophil	NN
539	549	maturation	maturation	NN
550	553	has	have	VBZ
554	558	been	be	VBN
559	568	suggested	suggest	VBN
569	573	from	from	IN
574	575	a	a	DT
576	583	variety	variety	NN
584	586	of	of	IN
587	594	sources	source	NNS
594	595	.	.	.

596	600	Here	here	RB
601	603	we	we	PRP
604	611	present	present	VBP
612	613	a	a	DT
614	620	review	review	NN
621	623	of	of	IN
624	627	the	the	DT
628	637	mechanism	mechanism	NN
638	640	of	of	IN
641	649	retinoic	retinoic	JJ
650	654	acid	acid	NN
655	663	receptor	receptor	NN
664	670	action	action	NN
671	674	and	and	CC
675	678	the	the	DT
679	684	major	major	JJ
685	693	evidence	evidence	NN
694	701	showing	show	VBG
702	706	that	that	IN
707	713	normal	normal	JJ
714	722	retinoid	retinoid	NN
723	732	signaling	signaling	NN
733	735	is	be	VBZ
736	744	required	require	VBN
745	748	for	for	IN
749	759	neutrophil	neutrophil	NN
760	770	maturation	maturation	NN
770	771	.	.	.