0	7	Natural	natural	JJ
8	16	variants	variant	NNS
17	19	of	of	IN
20	23	the	the	DT
24	29	HIV-1	HIV-1	NNP
30	34	long	long	JJ
35	43	terminal	terminal	JJ
44	50	repeat	repeat	NN
50	51	:	:	:
52	60	analysis	analysis	NN
61	63	of	of	IN
64	73	promoters	promoter	NNS
74	78	with	with	IN
79	89	duplicated	duplicated	JJ
90	93	DNA	dna	NN
94	104	regulatory	regulatory	JJ
105	111	motifs	motif	NNS
111	112	.	.	.

114	122	Sequence	sequence	NN
123	132	variation	variation	NN
133	135	in	in	IN
136	139	the	the	DT
140	144	long	long	JJ
145	153	terminal	terminal	JJ
154	160	repeat	repeat	NN
161	162	(	(	(
162	165	LTR	LTR	NNP
165	166	)	)	)
167	173	region	region	NN
174	176	of	of	IN
177	182	HIV-1	HIV-1	NNP
183	186	was	be	VBD
187	195	analyzed	analyze	VBN
196	198	in	in	IN
199	204	viral	viral	JJ
205	213	isolates	isolate	NNS
214	216	of	of	IN
217	219	17	17	CD
220	228	infected	infected	JJ
229	240	individuals	individual	NNS
240	241	.	.	.

242	245	Two	two	CD
246	253	classes	class	NNS
254	256	of	of	IN
257	260	LTR	LTR	NNP
261	265	size	size	NN
266	274	variants	variant	NNS
275	279	were	be	VBD
280	285	found	find	VBN
285	286	.	.	.

287	290	One	one	CD
291	296	HIV-1	HIV-1	NNP
297	304	variant	variant	NN
305	308	was	be	VBD
309	317	detected	detect	VBN
318	328	containing	contain	VBG
329	331	an	an	DT
332	342	additional	additional	JJ
343	350	binding	bind	VBG
351	355	site	site	NN
356	359	for	for	IN
360	363	the	the	DT
364	377	transcription	transcription	NN
378	384	factor	factor	NN
385	388	Sp1	sp1	NN
388	389	.	.	.

390	397	Another	another	DT
398	401	LTR	LTR	NNP
402	406	size	size	NN
407	416	variation	variation	NN
417	420	was	be	VBD
421	429	observed	observe	VBN
430	432	in	in	IN
433	437	four	four	CD
438	446	patients	patient	NNS
447	449	in	in	IN
450	451	a	a	DT
452	458	region	region	NN
459	463	just	just	RB
464	472	upstream	upstream	RB
473	475	of	of	IN
476	479	the	the	DT
480	488	NF-kappa	NF-kappa	NNP
489	490	B	B	NNP
491	499	enhancer	enhancer	NN
499	500	.	.	.

501	505	This	this	DT
506	515	variation	variation	NN
516	519	was	be	VBD
520	523	the	the	DT
524	530	result	result	NN
531	533	of	of	IN
534	535	a	a	DT
536	547	duplication	duplication	NN
548	550	of	of	IN
551	552	a	a	DT
553	558	short	short	JJ
559	562	DNA	dna	NN
563	571	sequence	sequence	NN
572	573	(	(	(
573	582	CTG-motif	ctg-motif	NN
582	583	)	)	)
583	584	.	.	.

585	589	Cell	cell	NN
590	597	culture	culture	NN
598	609	experiments	experiment	NNS
610	622	demonstrated	demonstrate	VBD
623	627	that	that	IN
628	631	the	the	DT
632	639	natural	natural	JJ
640	647	variant	variant	NN
648	652	with	with	IN
653	657	four	four	CD
658	661	Sp1	sp1	NN
662	667	sites	site	NNS
668	671	had	have	VBD
672	673	a	a	DT
674	682	slightly	slightly	RB
683	689	higher	high	JJR
690	698	promoter	promoter	NN
699	707	activity	activity	NN
708	711	and	and	CC
712	717	viral	viral	JJ
718	729	replication	replication	NN
730	734	rate	rate	NN
735	739	than	than	IN
740	743	the	the	DT
744	752	isogenic	isogenic	JJ
753	760	control	control	NN
761	764	LTR	ltr	NN
765	769	with	with	IN
770	775	three	three	CD
776	779	Sp1	sp1	NN
780	785	sites	site	NNS
785	786	.	.	.

787	789	No	no	DT
790	798	positive	positive	JJ
799	805	effect	effect	NN
806	808	of	of	IN
809	812	the	the	DT
813	823	duplicated	duplicate	VBN
824	833	CTG-motif	ctg-motif	NN
834	839	could	could	MD
840	842	be	be	VB
843	851	detected	detect	VBN
851	852	.	.	.

853	855	In	in	IN
856	861	order	order	NN
862	864	to	to	TO
865	872	measure	measure	VB
873	878	small	small	JJ
879	890	differences	difference	NNS
891	893	in	in	IN
894	899	virus	virus	NN
900	910	production	production	NN
911	915	more	more	RBR
916	926	accurately	accurately	RB
926	927	,	,	,
928	933	equal	equal	JJ
934	941	amounts	amount	NNS
942	944	of	of	IN
945	946	a	a	DT
947	951	size	size	NN
952	959	variant	variant	NN
960	963	and	and	CC
964	967	the	the	DT
968	977	wild-type	wild-type	JJ
978	985	plasmid	plasmid	NN
986	990	were	be	VBD
991	1004	cotransfected	cotransfecte	VBN
1005	1009	into	into	IN
1010	1017	T-cells	T-cell	NNP
1017	1018	.	.	.

1019	1022	The	the	DT
1023	1028	virus	virus	NN
1029	1033	with	with	IN
1034	1038	four	four	CD
1039	1042	Sp1	sp1	NN
1043	1048	sites	site	NNS
1049	1052	did	do	VBD
1053	1060	outgrow	outgrow	VB
1061	1064	the	the	DT
1065	1070	three	three	CD
1071	1074	Sp1	sp1	NN
1075	1080	virus	virus	NN
1081	1083	in	in	IN
1084	1086	35	35	CD
1087	1091	days	day	NNS
1092	1094	of	of	IN
1095	1102	culture	culture	NN
1103	1106	and	and	CC
1107	1118	CTG-monomer	CTG-monomer	NNP
1119	1124	virus	virus	NN
1125	1136	outcompeted	outcompete	VBD
1137	1140	the	the	DT
1141	1150	CTG-dimer	CTG-dimer	NNP
1151	1156	virus	virus	NN
1157	1159	in	in	IN
1160	1162	42	42	CD
1163	1167	days	day	NNS
1167	1168	.	.	.

1169	1174	Based	base	VBN
1175	1177	on	on	IN
1178	1183	these	these	DT
1184	1191	results	result	NNS
1192	1194	we	we	PRP
1195	1203	estimate	estimate	VBP
1204	1205	a	a	DT
1206	1210	5-10	5-10	CD
1210	1211	%	%	NN
1212	1222	difference	difference	NN
1223	1225	in	in	IN
1226	1231	virus	virus	NN
1232	1242	production	production	NN
1243	1245	of	of	IN
1246	1249	the	the	DT
1250	1253	LTR	LTR	NNP
1254	1262	variants	variant	NNS
1263	1267	when	when	WRB
1268	1276	compared	compare	VBN
1277	1279	to	to	TO
1280	1284	that	that	DT
1285	1287	of	of	IN
1288	1297	wild-type	wild-type	JJ
1297	1298	.	.	.