0	7	Okadaic	okadaic	JJ
8	12	acid	acid	NN
13	15	is	be	VBZ
16	17	a	a	DT
18	24	potent	potent	JJ
25	32	inducer	inducer	NN
33	35	of	of	IN
36	40	AP-1	ap-1	NN
40	41	,	,	,
42	50	NF-kappa	NF-kappa	NNP
51	52	B	B	NNP
52	53	,	,	,
54	57	and	and	CC
58	63	tumor	tumor	NN
64	72	necrosis	necrosis	NN
73	85	factor-alpha	factor-alpha	NN
86	88	in	in	IN
89	94	human	human	JJ
95	96	B	B	NNP
97	108	lymphocytes	lymphocyte	NNS
108	109	.	.	.

111	120	Treatment	Treatment	NNP
121	123	of	of	IN
124	129	human	human	JJ
130	131	B	B	NNP
132	143	lymphocytes	lymphocyte	NNS
144	148	with	with	IN
149	151	an	an	DT
152	159	optimal	optimal	JJ
160	173	concentration	concentration	NN
174	176	of	of	IN
177	184	okadaic	okadaic	JJ
185	189	acid	acid	NN
189	190	,	,	,
191	193	an	an	DT
194	203	inhibitor	inhibitor	NN
204	206	of	of	IN
207	219	phosphatases	phosphatas	NNS
220	221	1	1	CD
222	225	and	and	CC
226	228	2A	2a	NN
228	229	,	,	,
230	238	resulted	result	VBD
239	241	in	in	IN
242	245	the	the	DT
246	255	induction	induction	NN
256	258	of	of	IN
259	262	the	the	DT
263	276	transcription	transcription	NN
277	283	factor	factor	NN
283	284	,	,	,
285	289	AP-1	ap-1	NN
290	293	and	and	CC
294	295	a	a	DT
296	302	marked	marked	JJ
303	311	increase	increase	NN
312	314	in	in	IN
315	323	NF-kappa	NF-kappa	NNP
324	325	B	B	NNP
326	332	levels	level	NNS
332	333	.	.	.

334	336	In	in	IN
337	345	contrast	contrast	NN
345	346	,	,	,
347	349	no	no	DT
350	356	effect	effect	NN
357	359	on	on	IN
360	363	the	the	DT
364	370	levels	level	NNS
371	373	of	of	IN
374	377	the	the	DT
378	385	octamer	octamer	NN
386	393	binding	binding	NN
394	402	proteins	protein	NNS
402	403	,	,	,
404	409	Oct-1	oct-1	NN
410	412	or	or	CC
413	418	Oct-2	oct-2	NN
418	419	,	,	,
420	424	were	be	VBD
425	430	found	find	VBN
430	431	.	.	.

432	437	Since	since	IN
438	442	both	both	CC
443	447	AP-1	ap-1	NN
448	451	and	and	CC
452	460	NF-kappa	NF-kappa	NNP
461	462	B	B	NNP
463	467	have	have	VBP
468	472	been	be	VBN
473	481	reported	report	VBN
482	484	to	to	TO
485	487	be	be	VB
488	497	important	important	JJ
498	500	in	in	IN
501	504	the	the	DT
505	514	induction	induction	NN
515	517	of	of	IN
518	521	the	the	DT
522	527	tumor	tumor	NN
528	536	necrosis	necrosis	NN
537	549	factor-alpha	factor-alpha	NN
550	551	(	(	(
551	560	TNF-alpha	TNF-alpha	NNP
560	561	)	)	)
562	566	gene	gene	NN
567	569	we	we	PRP
570	578	examined	examine	VBD
579	582	the	the	DT
583	590	effects	effect	NNS
591	593	of	of	IN
594	601	okadaic	okadaic	JJ
602	606	acid	acid	NN
607	609	on	on	IN
610	619	TNF-alpha	TNF-alpha	NNP
620	624	mRNA	mRNA	NNP
625	631	levels	level	NNS
631	632	.	.	.

633	642	Treatment	Treatment	NNP
643	647	with	with	IN
648	655	okadaic	okadaic	JJ
656	660	acid	acid	NN
661	669	resulted	result	VBD
670	672	in	in	IN
673	674	a	a	DT
675	683	striking	striking	JJ
684	692	increase	increase	NN
693	695	in	in	IN
696	705	TNF-alpha	TNF-alpha	NNP
706	710	mRNA	mRNA	NNP
711	722	transcripts	transcript	NNS
723	729	within	within	IN
730	731	1	1	CD
732	733	h	h	NN
734	736	of	of	IN
737	748	stimulation	stimulation	NN
749	752	and	and	CC
753	758	large	large	JJ
759	766	amounts	amount	NNS
767	769	of	of	IN
770	779	TNF-alpha	TNF-alpha	NNP
780	784	were	be	VBD
785	793	released	release	VBN
794	798	into	into	IN
799	802	the	the	DT
803	810	culture	culture	NN
811	816	media	medium	NNS
816	817	.	.	.

818	826	Although	although	IN
827	834	okadaic	okadaic	JJ
835	839	acid	acid	NN
840	848	provides	provide	VBZ
849	850	a	a	DT
851	857	potent	potent	JJ
858	867	inductive	inductive	JJ
868	874	signal	signal	NN
875	878	for	for	IN
879	883	AP-1	AP-1	NNP
884	887	and	and	CC
888	896	NF-kappa	NF-kappa	NNP
897	898	B	B	NNP
899	901	it	it	PRP
902	905	did	do	VBD
906	909	not	not	RB
910	916	induce	induce	VB
917	923	either	either	CC
924	925	B	B	NNP
926	930	cell	cell	NN
931	944	proliferation	proliferation	NN
945	947	or	or	CC
948	962	immunoglobulin	immunoglobulin	NN
963	972	secretion	secretion	NN
972	973	.	.	.