0	15	Transcriptional	transcriptional	JJ
16	26	regulation	regulation	NN
27	33	during	during	IN
34	40	T-cell	t-cell	NN
41	52	development	development	NN
52	53	:	:	:
54	57	the	the	DT
58	63	alpha	alpha	NN
64	67	TCR	TCR	NNP
68	72	gene	gene	NN
73	75	as	as	IN
76	77	a	a	DT
78	87	molecular	molecular	JJ
88	93	model	model	NN
93	94	.	.	.

96	99	The	the	DT
100	110	regulation	regulation	NN
111	113	of	of	IN
114	118	gene	gene	NN
119	129	expression	expression	NN
130	136	during	during	IN
137	147	lymphocyte	lymphocyte	NN
148	163	differentiation	differentiation	NN
164	166	is	be	VBZ
167	168	a	a	DT
169	176	complex	complex	JJ
177	184	process	process	NN
185	194	involving	involve	VBG
195	207	interactions	interaction	NNS
208	215	between	between	IN
216	224	multiple	multiple	JJ
225	233	positive	positive	JJ
234	237	and	and	CC
238	246	negative	negative	JJ
247	262	transcriptional	transcriptional	JJ
263	273	regulatory	regulatory	JJ
274	282	elements	element	NNS
282	283	.	.	.

284	286	In	in	IN
287	291	this	this	DT
292	299	article	article	NN
299	300	,	,	,
301	316	transcriptional	transcriptional	JJ
317	327	regulation	regulation	NN
328	330	of	of	IN
331	334	the	the	DT
335	345	archetypal	archetypal	JJ
346	361	T-cell-specific	t-cell-specific	JJ
362	366	gene	gene	NN
366	367	,	,	,
368	373	alpha	alpha	NN
374	377	TCR	TCR	NNP
377	378	,	,	,
379	381	is	be	VBZ
382	391	discussed	discuss	VBN
391	392	.	.	.

393	398	Major	major	JJ
399	405	recent	recent	JJ
406	418	developments	development	NNS
418	419	,	,	,
420	429	including	include	VBG
430	433	the	the	DT
434	448	identification	identification	NN
449	451	of	of	IN
452	457	novel	novel	JJ
458	466	families	family	NNS
467	469	of	of	IN
470	483	transcription	transcription	NN
484	491	factors	factor	NNS
492	496	that	that	WDT
497	505	regulate	regulate	VBP
506	514	multiple	multiple	JJ
515	521	T-cell	t-cell	NN
522	527	genes	gene	NNS
528	534	during	during	IN
535	544	thymocyte	thymocyte	NN
545	553	ontogeny	ontogeny	NN
554	557	and	and	CC
558	564	T-cell	t-cell	NN
565	575	activation	activation	NN
575	576	,	,	,
577	580	are	be	VBP
581	590	described	describe	VBN
590	591	.	.	.