0 11 Interleukin Interleukin NNP 12 21 6-induced 6-induced JJ 22 37 differentiation differentiation NN 38 40 of of IN 41 42 a a DT 43 48 human human JJ 49 50 B B NNP 51 55 cell cell NN 56 60 line line NN 61 65 into into IN 66 79 IgM-secreting igm-secreting JJ 80 86 plasma plasma NN 87 92 cells cell NNS 93 95 is be VBZ 96 104 mediated mediate VBN 105 107 by by IN 108 113 c-fos c-fos NN 113 114 . . . 116 119 The the DT 120 124 role role NN 125 127 of of IN 128 131 the the DT 132 145 protooncogene protooncogene NN 146 151 c-fos c-fos NN 152 154 in in IN 155 166 interleukin interleukin NN 167 168 ( ( ( 168 170 IL IL NNP 170 171 ) ) ) 172 181 6-induced 6-induced JJ 182 183 B B NNP 184 188 cell cell NN 189 204 differentiation differentiation NN 205 208 was be VBD 209 217 assessed assess VBN 217 218 . . . 219 228 Treatment Treatment NNP 229 231 of of IN 232 235 SKW SKW NNP 236 239 6.4 6.4 CD 240 245 cells cell NNS 246 250 with with IN 251 253 IL IL NNP 254 255 6 6 CD 256 263 induced induce VBD 264 265 a a DT 266 275 transient transient JJ 276 279 and and CC 280 285 early early JJ 286 297 stimulation stimulation NN 298 300 of of IN 301 306 c-fos c-fos NN 307 312 sense sense NN 313 317 mRNA mrna NN 318 328 expression expression NN 328 329 . . . 330 333 The the DT 334 340 effect effect NN 341 349 appeared appear VBD 350 356 within within IN 357 359 30 30 CD 360 363 min min NN 364 367 and and CC 368 376 returned return VBD 377 379 to to TO 380 385 basal basal JJ 386 392 levels level NNS 393 398 after after IN 399 400 2 2 CD 401 402 h h NN 402 403 . . . 404 407 The the DT 408 416 addition addition NN 417 419 of of IN 420 429 antisense antisense JJ 430 446 oligonucleotides oligonucleotide NNS 447 449 to to TO 450 455 c-fos c-fos NN 456 469 significantly significantly RB 470 479 inhibited inhibit VBD 480 482 IL IL NNP 483 492 6-induced 6-induced JJ 493 496 IgM IgM NNP 497 507 production production NN 508 510 by by IN 511 514 SKW SKW NNP 515 518 6.4 6.4 CD 519 524 cells cell NNS 525 526 ( ( ( 526 527 p p NN 528 532 less less JJR 533 537 than than IN 538 543 0.001 0.001 CD 543 544 ) ) ) 544 545 , , , 546 553 whereas whereas IN 554 561 control control NN 562 578 oligonucleotides oligonucleotide NNS 579 582 had have VBD 583 585 no no DT 586 596 inhibitory inhibitory JJ 597 603 effect effect NN 603 604 . . . 605 610 These these DT 611 618 results result NNS 619 627 indicate indicate VBP 628 632 that that IN 633 643 activation activation NN 644 646 of of IN 647 652 c-fos c-fos NN 653 655 is be VBZ 656 664 involved involve VBN 665 667 in in IN 668 670 IL IL NNP 671 680 6-induced 6-induced JJ 681 696 differentiation differentiation NN 697 699 of of IN 700 703 SKW SKW NNP 704 707 6.4 6.4 CD 708 713 cells cell NNS 714 718 into into IN 719 732 IgM-secreting igm-secreting JJ 733 738 cells cell NNS 738 739 . . .