0 7 Towards towards IN 8 9 a a DT 10 19 molecular molecular JJ 20 33 understanding understanding NN 34 36 of of IN 37 43 T-cell t-cell NN 44 59 differentiation differentiation NN 59 60 . . . 62 70 Lymphoid lymphoid JJ 71 86 differentiation differentiation NN 87 89 is be VBZ 90 93 one one CD 94 96 of of IN 97 100 the the DT 101 105 best good JJS 106 113 studied study VBN 114 122 examples example NNS 123 125 of of IN 126 135 mammalian mammalian JJ 136 147 development development NN 147 148 . . . 149 153 Here here RB 154 158 Hans Hans NNP 159 166 Clevers Clevers NNP 167 170 and and CC 171 178 Michael Michael NNP 179 183 Owen Owen NNP 184 192 describe describe VBP 193 196 how how WRB 197 200 the the DT 201 208 cloning cloning NN 209 211 of of IN 212 215 the the DT 216 221 genes gene NNS 222 226 that that WDT 227 233 encode encode VBP 234 249 T-cell-specific t-cell-specific JJ 250 258 membrane membrane NN 259 267 proteins protein NNS 268 274 allows allow VBZ 275 278 the the DT 279 293 identification identification NN 294 296 of of IN 297 310 transcription transcription NN 311 318 factors factor NNS 319 323 that that WDT 324 331 control control VBP 332 335 the the DT 336 346 expression expression NN 347 349 of of IN 350 355 these these DT 356 362 T-cell t-cell NN 363 368 genes gene NNS 368 369 . . . 370 374 Such such JJ 375 388 transcription transcription NN 389 396 factors factor NNS 397 401 play play VBP 402 403 a a DT 404 407 key key JJ 408 412 role role NN 413 415 in in IN 416 419 the the DT 420 431 development development NN 432 434 of of IN 435 438 the the DT 439 445 mature mature JJ 446 452 T-cell t-cell NN 453 462 phenotype phenotype NN 463 465 by by IN 466 477 functioning function VBG 478 480 as as IN 481 482 ‘ ` `` 482 488 master master NN 489 499 regulators regulator NNS 500 502 of of IN 503 509 T-cell t-cell NN 510 525 differentiation differentiation NN 525 526 ’ ' '' 526 527 . . .