0	13	Transcription	Transcription	NNP
14	20	factor	factor	NN
21	33	requirements	requirement	NNS
34	37	for	for	IN
38	40	U2	u2	NN
41	55	snRNA-encoding	snrna-encoding	JJ
56	60	gene	gene	NN
61	71	activation	activation	NN
72	74	in	in	IN
75	76	B	B	NNP
77	85	lymphoid	lymphoid	JJ
86	91	cells	cell	NNS
91	92	.	.	.

94	107	Transcription	transcription	NN
108	110	of	of	IN
111	112	a	a	DT
113	118	human	human	JJ
119	121	U2	u2	NN
122	127	small	small	JJ
128	135	nuclear	nuclear	JJ
136	155	RNA(snRNA)-encoding	rna(snrna)-encoding	JJ
156	160	gene	gene	NN
161	163	in	in	IN
164	168	HeLa	HeLa	NNP
169	174	cells	cell	NNS
175	183	requires	require	VBZ
184	185	a	a	DT
186	192	distal	distal	JJ
193	201	enhancer	enhancer	NN
202	209	element	element	NN
209	210	,	,	,
211	216	which	which	WDT
217	219	is	be	VBZ
220	228	composed	compose	VBN
229	231	of	of	IN
232	235	one	one	CD
236	243	octamer	octamer	NN
244	249	motif	motif	NN
250	251	(	(	(
251	254	Oct	Oct	NNP
254	255	)	)	)
256	259	and	and	CC
260	265	three	three	CD
266	268	Sp	sp	NN
269	278	1-binding	1-binding	JJ
279	284	sites	site	NNS
284	285	.	.	.

286	288	To	to	TO
289	294	study	study	VB
295	298	the	the	DT
299	312	transcription	transcription	NN
313	319	factor	factor	NN
320	331	requirement	requirement	NN
332	334	in	in	IN
335	342	B-cells	B-cell	NNP
342	343	,	,	,
344	353	different	different	JJ
354	356	U2	u2	NN
357	365	enhancer	enhancer	NN
366	379	constructions	construction	NNS
380	384	were	be	VBD
385	396	transfected	transfecte	VBN
397	401	into	into	IN
402	405	the	the	DT
406	414	lymphoid	lymphoid	JJ
415	419	cell	cell	NN
420	424	line	line	NN
424	425	,	,	,
426	431	BJA-B	BJA-B	NNP
431	432	.	.	.

433	436	The	the	DT
437	444	results	result	NNS
445	451	showed	show	VBD
452	456	that	that	IN
457	460	the	the	DT
461	471	activation	activation	NN
472	474	of	of	IN
475	477	U2	u2	NN
478	483	snRNA	snrna	NN
484	497	transcription	transcription	NN
498	500	in	in	IN
501	508	B-cells	B-cell	NNP
509	513	also	also	RB
514	522	requires	require	VBZ
523	525	an	an	DT
526	534	enhancer	enhancer	NN
535	545	comprising	comprise	VBG
546	550	both	both	CC
551	554	the	the	DT
555	558	Oct	Oct	NNP
559	562	and	and	CC
563	565	at	at	IN
566	571	least	least	JJS
572	575	one	one	CD
576	578	Sp	Sp	NNP
579	588	1-binding	1-binding	JJ
589	593	site	site	NN
593	594	.	.	.

595	603	Deletion	deletion	NN
604	606	of	of	IN
607	610	all	all	PDT
611	614	the	the	DT
615	617	Sp	sp	NN
618	627	1-binding	1-binding	JJ
628	633	sites	site	NNS
634	638	from	from	IN
639	642	the	the	DT
643	651	enhancer	enhancer	NN
652	659	reduces	reduce	VBZ
660	673	transcription	transcription	NN
674	676	by	by	IN
677	682	80-90	80-90	CD
682	683	%	%	NN
684	686	in	in	IN
687	691	HeLa	HeLa	NNP
691	692	,	,	,
693	695	as	as	RB
696	700	well	well	RB
701	703	as	as	IN
704	706	in	in	IN
707	712	BJA-B	bja-b	NN
713	718	cells	cell	NNS
718	719	,	,	,
720	727	whereas	whereas	IN
728	731	the	the	DT
732	739	removal	removal	NN
740	742	of	of	IN
743	746	the	the	DT
747	762	octamer-binding	octamer-binding	JJ
763	767	site	site	NN
768	775	reduces	reduce	VBZ
776	789	transcription	transcription	NN
790	792	to	to	TO
793	799	levels	level	NNS
800	805	below	below	IN
806	815	detection	detection	NN
816	818	in	in	IN
819	823	both	both	DT
824	828	cell	cell	NN
829	834	types	type	NNS
834	835	.	.	.

836	845	Enhancers	enhancer	NNS
846	856	containing	contain	VBG
857	858	a	a	DT
859	865	single	single	JJ
866	869	Oct	Oct	NNP
870	874	have	have	VBP
874	875	,	,	,
876	888	nevertheless	nevertheless	RB
888	889	,	,	,
890	893	the	the	DT
894	902	capacity	capacity	NN
903	905	to	to	TO
906	915	partially	partially	RB
916	924	activate	activate	VB
925	927	U2	u2	NN
928	933	snRNA	snrna	NN
934	947	transcription	transcription	NN
948	950	in	in	IN
951	955	both	both	DT
956	960	HeLa	HeLa	NNP
961	966	cells	cell	NNS
966	967	,	,	,
968	970	in	in	IN
971	976	which	which	WDT
977	981	only	only	RB
982	987	OTF-1	otf-1	NN
988	990	is	be	VBZ
991	1000	expressed	express	VBN
1000	1001	,	,	,
1002	1005	and	and	CC
1006	1008	in	in	IN
1009	1014	BJA-B	bja-b	NN
1015	1020	cells	cell	NNS
1021	1023	in	in	IN
1024	1029	which	which	WDT
1030	1035	OTF-2	otf-2	NN
1036	1038	is	be	VBZ
1039	1042	the	the	DT
1043	1056	predominantly	predominantly	RB
1057	1066	expressed	express	VBN
1067	1082	octamer-binding	octamer-binding	JJ
1083	1089	factor	factor	NN
1089	1090	.	.	.

1091	1094	The	the	DT
1095	1099	most	most	RBS
1100	1106	likely	likely	JJ
1107	1121	interpretation	interpretation	NN
1122	1124	of	of	IN
1125	1128	our	our	PRP$
1129	1136	results	result	NNS
1137	1139	is	be	VBZ
1140	1144	that	that	IN
1145	1149	both	both	CC
1150	1153	the	the	DT
1154	1164	ubiquitous	ubiquitous	JJ
1165	1178	transcription	transcription	NN
1179	1185	factor	factor	NN
1185	1186	,	,	,
1187	1192	OTF-1	OTF-1	NNP
1192	1193	,	,	,
1194	1197	and	and	CC
1198	1201	the	the	DT
1202	1217	B-cell-specific	b-cell-specific	JJ
1218	1231	transcription	transcription	NN
1232	1238	factor	factor	NN
1238	1239	,	,	,
1240	1245	OTF-2	OTF-2	NNP
1245	1246	,	,	,
1247	1250	can	can	MD
1251	1259	activate	activate	VB
1260	1262	U2	u2	NN
1263	1268	snRNA	snrna	NN
1269	1282	transcription	transcription	NN
1282	1283	.	.	.

1284	1287	The	the	DT
1288	1295	results	result	NNS
1296	1300	also	also	RB
1301	1309	revealed	reveal	VBD
1310	1311	a	a	DT
1312	1319	similar	similar	JJ
1320	1330	functional	functional	JJ
1331	1342	cooperation	cooperation	NN
1343	1350	between	between	IN
1351	1354	the	the	DT
1355	1368	transcription	transcription	NN
1369	1376	factors	factor	NNS
1377	1382	which	which	WDT
1383	1387	bind	bind	VBP
1388	1390	to	to	TO
1391	1394	the	the	DT
1395	1398	Oct	Oct	NNP
1399	1402	and	and	CC
1403	1406	the	the	DT
1407	1415	adjacent	adjacent	JJ
1416	1418	Sp	Sp	NNP
1419	1428	1-binding	1-binding	JJ
1429	1433	site	site	NN
1434	1436	in	in	IN
1437	1442	BJA-B	bja-b	NN
1443	1448	cells	cell	NNS
1448	1449	,	,	,
1450	1452	as	as	IN
1453	1456	has	have	VBZ
1457	1461	been	be	VBN
1462	1470	observed	observe	VBN
1471	1473	in	in	IN
1474	1478	HeLa	HeLa	NNP
1479	1484	cells	cell	NNS
1484	1485	,	,	,
1486	1491	since	since	IN
1492	1493	a	a	DT
1494	1502	template	template	NN
1503	1508	which	which	WDT
1509	1517	contains	contain	VBZ
1518	1519	a	a	DT
1520	1524	weak	weak	JJ
1525	1532	binding	bind	VBG
1533	1537	site	site	NN
1538	1541	for	for	IN
1542	1546	OTFs	OTF	NNP
1547	1556	expresses	express	VBZ
1557	1566	wild-type	wild-type	JJ
1567	1573	levels	level	NNS
1574	1576	of	of	IN
1577	1579	U2	U2	NNP
1580	1585	snRNA	snRNA	NNP
1586	1588	in	in	IN
1589	1593	both	both	DT
1594	1598	cell	cell	NN
1599	1604	types	type	NNS
1605	1609	when	when	WRB
1610	1613	the	the	DT
1614	1618	weak	weak	JJ
1619	1634	octamer-binding	octamer-binding	JJ
1635	1639	site	site	NN
1640	1642	is	be	VBZ
1643	1651	combined	combine	VBN
1652	1656	with	with	IN
1657	1658	a	a	DT
1659	1661	Sp	Sp	NNP
1662	1671	1-binding	1-binding	JJ
1672	1676	site	site	NN
1676	1677	.	.	.