0 8 Activity activity NN 9 11 of of IN 12 15 the the DT 16 21 kappa kappa NN 22 23 B B NNP 24 32 enhancer enhancer NN 33 35 of of IN 36 39 the the DT 40 53 interleukin-2 interleukin-2 NN 54 62 receptor receptor NN 63 68 alpha alpha NN 69 74 chain chain NN 75 77 in in IN 78 85 somatic somatic JJ 86 90 cell cell NN 91 98 hybrids hybrid NNS 99 101 is be VBZ 102 113 accompanied accompany VBN 114 116 by by IN 117 120 the the DT 121 128 nuclear nuclear JJ 129 141 localization localization NN 142 144 of of IN 145 153 NF-kappa NF-kappa NNP 154 156 B. B. NNP 158 161 The the DT 162 165 two two CD 166 173 nuclear nuclear JJ 174 182 proteins protein NNS 183 191 NF-kappa NF-kappa NNP 192 193 B B NNP 194 195 ( ( ( 195 205 consisting consist VBG 206 208 of of IN 209 217 subunits subunit NNS 218 221 p50 p50 NN 222 225 and and CC 226 229 p65 p65 NN 229 230 ) ) ) 231 234 and and CC 235 238 the the DT 239 250 DNA-binding dna-binding JJ 251 258 subunit subunit NN 259 261 of of IN 262 270 NF-kappa NF-kappa NNP 271 272 B B NNP 273 274 ( ( ( 274 277 p50 p50 NN 277 278 ) ) ) 279 281 by by IN 282 288 itself itself PRP 288 289 , , , 290 294 also also RB 295 301 called call VBN 302 306 KBF1 kbf1 NN 306 307 , , , 308 311 are be VBP 312 326 constitutively constitutively RB 327 336 expressed express VBN 337 340 and and CC 341 350 localized localize VBN 351 353 in in IN 354 357 the the DT 358 365 nucleus nucleus NN 366 368 of of IN 369 372 the the DT 373 378 human human JJ 379 385 T-cell t-cell NN 386 390 line line NN 391 395 IARC IARC NNP 396 401 301.5 301.5 CD 401 402 . . . 403 405 In in IN 406 411 order order NN 412 414 to to TO 415 421 define define VB 422 425 the the DT 426 431 roles role NNS 432 434 of of IN 435 440 these these DT 441 444 two two CD 445 452 factors factor NNS 452 453 , , , 454 459 which which WDT 460 464 bind bind VBP 465 467 to to TO 468 471 the the DT 472 476 same same JJ 477 482 kappa kappa NN 483 484 B b NN 485 494 enhancers enhancer NNS 494 495 , , , 496 498 in in IN 499 512 transcription transcription NN 513 523 activation activation NN 524 526 we we PRP 527 531 have have VBP 532 540 prepared prepare VBN 541 548 somatic somatic JJ 549 553 cell cell NN 554 561 hybrids hybrid NNS 562 569 between between IN 570 574 IARC IARC NNP 575 580 301.5 301.5 CD 581 584 and and CC 585 586 a a DT 587 593 murine murine JJ 594 601 myeloma myeloma NN 601 602 . . . 603 607 Most most JJS 608 615 hybrids hybrid NNS 616 623 express express VBP 624 628 both both CC 629 633 KBF1 KBF1 NNP 634 637 and and CC 638 646 NF-kappa NF-kappa NNP 647 648 B B NNP 649 651 in in IN 652 657 their their PRP$ 658 664 nuclei nucleus NNS 664 665 , , , 666 669 but but CC 670 673 one one CD 674 680 hybrid hybrid NN 681 690 expresses express VBZ 691 695 only only RB 696 700 KBF1 kbf1 NN 700 701 . . . 702 705 The the DT 706 711 kappa kappa NN 712 713 B B NNP 714 722 enhancer enhancer NN 723 725 of of IN 726 729 the the DT 730 734 gene gene NN 735 743 encoding encode VBG 744 747 the the DT 748 761 interleukin-2 interleukin-2 NN 762 763 ( ( ( 763 767 IL-2 il-2 NN 767 768 ) ) ) 769 777 receptor receptor NN 778 783 alpha alpha NN 784 789 chain chain NN 790 791 ( ( ( 791 796 IL-2R IL-2R NNP 797 802 alpha alpha NN 802 803 ) ) ) 804 806 is be VBZ 807 817 functional functional JJ 818 822 only only RB 823 825 in in IN 826 829 the the DT 830 837 hybrids hybrid NNS 838 848 expressing express VBG 849 856 nuclear nuclear JJ 857 865 NF-kappa NF-kappa NNP 866 868 B. B. NNP 869 874 These these DT 875 883 findings finding NNS 884 888 show show VBP 889 893 that that IN 894 901 nuclear nuclear JJ 902 910 NF-kappa NF-kappa NNP 911 912 B B NNP 913 915 is be VBZ 916 925 necessary necessary JJ 926 928 to to TO 929 937 activate activate VB 938 941 the the DT 942 947 kappa kappa NN 948 949 B B NNP 950 958 enhancer enhancer NN 958 959 , , , 960 965 while while IN 966 970 KBF1 kbf1 NN 971 973 by by IN 974 980 itself itself PRP 981 983 is be VBZ 984 987 not not RB 988 998 sufficient sufficient JJ 998 999 . . . 1000 1002 We we PRP 1003 1010 propose propose VBP 1011 1015 that that IN 1016 1020 KBF1 kbf1 NN 1021 1023 is be VBZ 1024 1025 a a DT 1026 1037 competitive competitive JJ 1038 1047 inhibitor inhibitor NN 1048 1050 of of IN 1051 1059 NF-kappa NF-kappa NNP 1060 1061 B B NNP 1062 1065 and and CC 1066 1073 discuss discuss VB 1074 1077 how how WRB 1078 1083 these these DT 1084 1091 factors factor NNS 1092 1095 may may MD 1096 1098 be be VB 1099 1107 involved involve VBN 1108 1110 in in IN 1111 1114 the the DT 1115 1124 transient transient JJ 1125 1135 expression expression NN 1136 1138 of of IN 1139 1143 IL-2 il-2 NN 1144 1147 and and CC 1148 1153 IL-2R IL-2R NNP 1154 1159 alpha alpha NN 1160 1165 genes gene NNS 1166 1172 during during IN 1173 1176 the the DT 1177 1183 immune immune JJ 1184 1192 response response NN 1192 1193 . . .