0 16 Characterization characterization NN 17 19 of of IN 20 22 an an DT 23 38 immediate-early immediate-early JJ 39 43 gene gene NN 44 51 induced induce VBN 52 54 in in IN 55 63 adherent adherent JJ 64 73 monocytes monocyte NNS 74 78 that that WDT 79 86 encodes encode VBZ 87 88 I i NN 89 94 kappa kappa NN 95 101 B-like b-like JJ 102 110 activity activity NN 110 111 . . . 113 115 We we PRP 116 120 have have VBP 121 127 cloned clone VBN 128 129 a a DT 130 135 group group NN 136 138 of of IN 139 144 cDNAs cdna NNS 145 157 representing represent VBG 158 163 mRNAs mrna NNS 164 168 that that WDT 169 172 are be VBP 173 180 rapidly rapidly RB 181 188 induced induce VBN 189 198 following follow VBG 199 208 adherence adherence NN 209 211 of of IN 212 217 human human JJ 218 227 monocytes monocyte NNS 227 228 . . . 229 232 One one CD 233 235 of of IN 236 239 the the DT 240 247 induced induce VBN 248 259 transcripts transcript NNS 260 261 ( ( ( 261 266 MAD-3 MAD-3 NNP 266 267 ) ) ) 268 275 encodes encode VBZ 276 277 a a DT 278 285 protein protein NN 286 288 of of IN 289 292 317 317 CD 293 298 amino amino NN 299 304 acids acid NNS 305 309 with with IN 310 313 one one CD 314 320 domain domain NN 321 331 containing contain VBG 332 336 five five CD 337 343 tandem tandem JJ 344 351 repeats repeat NNS 352 354 of of IN 355 358 the the DT 359 372 cdc10/ankyrin cdc10/ankyrin NN 373 378 motif motif NN 378 379 , , , 380 385 which which WDT 386 388 is be VBZ 389 391 60 60 CD 391 392 % % NN 393 400 similar similar JJ 401 402 ( ( ( 402 404 46 46 CD 404 405 % % NN 406 415 identical identical JJ 415 416 ) ) ) 417 419 to to TO 420 423 the the DT 424 431 ankyrin ankyrin NN 432 438 repeat repeat NN 439 445 region region NN 446 448 of of IN 449 452 the the DT 453 462 precursor precursor NN 463 465 of of IN 466 474 NF-kappa NF-kappa NNP 475 481 B/KBF1 B/KBF1 NNP 482 485 p50 p50 NN 485 486 . . . 487 490 The the DT 491 501 C-terminus C-terminus NNP 502 505 has have VBZ 506 507 a a DT 508 516 putative putative JJ 517 524 protein protein NN 525 531 kinase kinase NNP 532 533 C C NNP 534 549 phosphorylation phosphorylation NN 550 554 site site NN 554 555 . . . 556 558 In in FW 559 564 vitro vitro FW 565 575 translated translate VBN 576 581 MAD-3 MAD-3 NNP 582 589 protein protein NN 590 593 was be VBD 594 599 found find VBN 600 602 to to TO 603 615 specifically specifically RB 616 623 inhibit inhibit VB 624 627 the the DT 628 639 DNA-binding dna-binding JJ 640 648 activity activity NN 649 651 of of IN 652 655 the the DT 656 663 p50/p65 p50/p65 NN 664 672 NF-kappa NF-kappa NNP 673 674 B B NNP 675 682 complex complex NN 683 686 but but CC 687 690 not not RB 691 695 that that DT 696 698 of of IN 699 702 the the DT 703 710 p50/p50 p50/p50 NN 711 715 KBF1 kbf1 NN 716 722 factor factor NN 723 725 or or CC 726 728 of of IN 729 734 other other JJ 735 746 DNA-binding dna-binding JJ 747 755 proteins protein NNS 755 756 . . . 757 760 The the DT 761 766 MAD-3 MAD-3 NNP 767 771 cDNA cDNA NNP 772 779 encodes encode VBZ 780 782 an an DT 783 784 I i NN 785 790 kappa kappa NN 791 797 B-like b-like JJ 798 805 protein protein NN 806 810 that that WDT 811 813 is be VBZ 814 820 likely likely JJ 821 823 to to TO 824 826 be be VB 827 835 involved involve VBN 836 838 in in IN 839 849 regulation regulation NN 850 852 of of IN 853 868 transcriptional transcriptional JJ 869 878 responses response NNS 879 881 to to TO 882 890 NF-kappa NF-kappa NNP 891 892 B B NNP 892 893 , , , 894 903 including include VBG 904 922 adhesion-dependent adhesion-dependent JJ 923 931 pathways pathway NNS 932 934 of of IN 935 943 monocyte monocyte NN 944 954 activation activation NN 954 955 . . .