0 11 Suppression suppression NN 12 14 of of IN 15 22 signals signal NNS 23 31 required require VBN 32 35 for for IN 36 46 activation activation NN 47 49 of of IN 50 63 transcription transcription NN 64 70 factor factor NN 71 79 NF-kappa NF-kappa NNP 80 81 B B NNP 82 84 in in IN 85 90 cells cell NNS 91 105 constitutively constitutively RB 106 116 expressing express VBG 117 120 the the DT 121 127 HTLV-I HTLV-I NNP 128 131 Tax Tax NNP 132 139 protein protein NN 139 140 . . . 142 151 Transient transient JJ 152 162 short-term short-term JJ 163 173 expression expression NN 174 176 of of IN 177 180 the the DT 181 184 Tax Tax NNP 185 192 protein protein NN 193 195 of of IN 196 201 human human JJ 202 208 T-cell t-cell NN 209 217 leukemia leukemia NN 218 223 virus virus NN 224 230 type-I type-I NNP 231 232 ( ( ( 232 238 HTLV-I HTLV-I NNP 238 239 ) ) ) 240 245 leads lead VBZ 246 248 to to TO 249 259 activation activation NN 260 262 of of IN 263 266 the the DT 267 278 pleiotropic pleiotropic JJ 279 292 transcription transcription NN 293 299 factor factor NN 300 308 NF-kappa NF-kappa NNP 309 311 B. B. NNP 312 322 Consistent consistent JJ 323 327 with with IN 328 336 findings finding NNS 337 345 obtained obtain VBN 346 350 with with IN 351 360 transient transient JJ 361 371 expression expression NN 372 378 assays assay NNS 378 379 , , , 380 382 we we PRP 383 391 observed observe VBD 392 398 marked marked JJ 399 411 accumulation accumulation NN 412 414 of of IN 415 418 the the DT 419 432 transcription transcription NN 433 439 factor factor NN 440 448 NF-kappa NF-kappa NNP 449 450 B B NNP 451 453 in in IN 454 457 the the DT 458 465 nucleus nucleus NN 466 468 of of IN 469 476 Namalwa Namalwa NNP 477 478 B B NNP 479 487 lymphoid lymphoid JJ 488 493 cells cell NNS 493 494 , , , 495 500 which which WDT 501 515 constitutively constitutively RB 516 523 express express VBP 524 527 Tax Tax NNP 527 528 . . . 529 531 In in IN 532 540 contrast contrast NN 540 541 , , , 542 550 NF-kappa NF-kappa NNP 551 552 B B NNP 553 561 activity activity NN 562 565 was be VBD 566 569 not not RB 570 578 detected detect VBN 579 581 in in IN 582 585 the the DT 586 593 nucleus nucleus NN 594 603 following follow VBG 604 613 long-term long-term JJ 614 624 expression expression NN 625 627 of of IN 628 631 Tax Tax NNP 632 634 in in IN 635 641 Jurkat Jurkat NNP 642 643 T t NN 644 655 lymphocytes lymphocyte NNS 655 656 . . . 657 660 The the DT 661 668 ability ability NN 669 671 of of IN 672 676 both both DT 677 685 mitogens mitogen NNS 686 689 and and CC 690 699 cytokines cytokine NNS 700 702 to to TO 703 711 activate activate VB 712 720 NF-kappa NF-kappa NNP 721 722 B B NNP 723 726 was be VBD 727 731 also also RB 732 739 blocked block VBN 740 742 in in IN 743 749 Jurkat Jurkat NNP 750 755 cells cell NNS 756 770 constitutively constitutively RB 771 781 expressing express VBG 782 785 Tax Tax NNP 785 786 . . . 787 794 However however RB 794 795 , , , 796 799 the the DT 800 810 activation activation NN 811 813 of of IN 814 819 other other JJ 820 837 mitogen-inducible mitogen-inducible JJ 838 851 transcription transcription NN 852 859 factors factor NNS 859 860 , , , 861 865 such such JJ 866 868 as as IN 869 872 Fos Fos NNP 873 876 and and CC 877 880 Jun Jun NNP 880 881 , , , 882 885 was be VBD 886 896 unaffected unaffected JJ 896 897 . . . 898 902 Thus thus RB 902 903 , , , 904 913 depending depend VBG 914 916 on on IN 917 920 the the DT 921 929 cellular cellular JJ 930 941 environment environment NN 941 942 , , , 943 946 the the DT 947 953 short- short- JJ 954 957 and and CC 958 967 long-term long-term JJ 968 975 effects effect NNS 976 978 of of IN 979 982 Tax Tax NNP 983 993 expression expression NN 994 997 can can MD 998 1000 be be VB 1001 1006 quite quite RB 1007 1016 different different JJ 1016 1017 . . . 1018 1030 Consequently consequently RB 1030 1031 , , , 1032 1035 one one CD 1036 1044 function function NN 1045 1047 of of IN 1048 1051 Tax Tax NNP 1052 1054 in in IN 1055 1060 cells cell NNS 1061 1069 infected infect VBN 1070 1074 with with IN 1075 1081 HTLV-I HTLV-I NNP 1082 1087 might might MD 1088 1095 involve involve VB 1096 1114 cell-type-specific cell-type-specific JJ 1115 1126 suppression suppression NN 1126 1127 , , , 1128 1130 as as IN 1131 1138 opposed oppose VBN 1139 1141 to to TO 1142 1152 activation activation NN 1152 1153 , , , 1154 1156 of of IN 1157 1165 distinct distinct JJ 1166 1172 signal signal NN 1173 1181 pathways pathway NNS 1181 1182 . . . 1183 1186 The the DT 1187 1192 cells cell NNS 1193 1198 lines line NNS 1199 1208 described describe VBN 1209 1213 here here RB 1214 1220 should should MD 1221 1223 be be VB 1224 1230 useful useful JJ 1231 1234 for for IN 1235 1238 the the DT 1239 1250 delineation delineation NN 1251 1253 of of IN 1254 1263 signaling signaling NN 1264 1272 pathways pathway NNS 1273 1281 utilized utilize VBN 1282 1284 in in IN 1285 1288 the the DT 1289 1298 selective selective JJ 1299 1309 regulation regulation NN 1310 1312 of of IN 1313 1317 gene gene NN 1318 1328 expression expression NN 1328 1329 . . .