0 9 Induction Induction NNP 10 12 of of IN 13 18 NF-KB NF-KB NNP 19 25 during during IN 26 34 monocyte monocyte NN 35 50 differentiation differentiation NN 51 53 by by IN 54 57 HIV HIV NNP 58 62 type type NN 63 64 1 1 CD 65 74 infection infection NN 74 75 . . . 77 80 The the DT 81 91 production production NN 92 94 of of IN 95 100 human human JJ 101 117 immunodeficiency immunodeficiency NN 118 123 virus virus NN 124 128 type type NN 129 130 1 1 CD 131 132 ( ( ( 132 137 HIV-1 HIV-1 NNP 137 138 ) ) ) 139 146 progeny progeny NN 147 150 was be VBD 151 159 followed follow VBN 160 162 in in IN 163 166 the the DT 167 171 U937 u937 NN 172 184 promonocytic promonocytic JJ 185 189 cell cell NN 190 194 line line NN 195 200 after after IN 201 212 stimulation stimulation NN 213 219 either either CC 220 224 with with IN 225 233 retinoic retinoic JJ 234 238 acid acid NN 239 241 or or CC 242 245 PMA PMA NNP 245 246 , , , 247 250 and and CC 251 253 in in IN 254 262 purified purify VBN 263 268 human human JJ 269 278 monocytes monocyte NNS 279 282 and and CC 283 294 macrophages macrophage NNS 294 295 . . . 296 311 Electrophoretic electrophoretic JJ 312 320 mobility mobility NN 321 326 shift shift NN 327 333 assays assay NNS 334 337 and and CC 338 350 Southwestern southwestern NN 351 359 blotting blotting NN 360 371 experiments experiment NNS 372 376 were be VBD 377 381 used use VBN 382 384 to to TO 385 391 detect detect VB 392 395 the the DT 396 403 binding binding NN 404 406 of of IN 407 415 cellular cellular JJ 416 431 transactivation transactivation NN 432 438 factor factor NN 439 444 NF-KB nf-kb NN 445 447 to to TO 448 451 the the DT 452 458 double double JJ 459 468 repeat-KB repeat-kb NN 469 477 enhancer enhancer NN 478 486 sequence sequence NN 487 494 located located JJ 495 497 in in IN 498 501 the the DT 502 506 long long JJ 507 515 terminal terminal JJ 516 522 repeat repeat NN 522 523 . . . 524 527 PMA PMA NNP 528 537 treatment treatment NN 537 538 , , , 539 542 and and CC 543 546 not not RB 547 555 retinoic retinoic JJ 556 560 acid acid NN 561 570 treatment treatment NN 571 573 of of IN 574 577 the the DT 578 582 U937 u937 NN 583 588 cells cell NNS 589 593 acts act VBZ 594 596 in in IN 597 605 inducing induce VBG 606 611 NF-KB NF-KB NNP 612 622 expression expression NN 623 625 in in IN 626 629 the the DT 630 636 nuclei nucleus NNS 636 637 . . . 638 640 In in IN 641 648 nuclear nuclear JJ 649 657 extracts extract NNS 658 662 from from IN 663 672 monocytes monocyte NNS 673 675 or or CC 676 687 macrophages macrophage NNS 687 688 , , , 689 698 induction induction NN 699 701 of of IN 702 707 NF-KB NF-KB NNP 708 716 occurred occur VBD 717 721 only only RB 722 724 if if IN 725 728 the the DT 729 734 cells cell NNS 735 739 were be VBD 740 750 previously previously RB 751 759 infected infect VBN 760 764 with with IN 765 770 HIV-1 HIV-1 NNP 770 771 . . . 772 776 When when WRB 777 781 U937 u937 NN 782 787 cells cell NNS 788 792 were be VBD 793 801 infected infect VBN 802 806 with with IN 807 812 HIV-1 HIV-1 NNP 812 813 , , , 814 816 no no DT 817 826 induction induction NN 827 829 of of IN 830 835 NF-KB NF-KB NNP 836 842 factor factor NN 843 846 was be VBD 847 855 detected detect VBN 855 856 , , , 857 864 whereas whereas IN 865 869 high high JJ 870 875 level level NN 876 878 of of IN 879 886 progeny progeny NN 887 894 virions virion NNS 895 898 was be VBD 899 907 produced produce VBN 907 908 , , , 909 919 suggesting suggest VBG 920 924 that that IN 925 929 this this DT 930 936 factor factor NN 937 940 was be VBD 941 944 not not RB 945 953 required require VBN 954 957 for for IN 958 963 viral viral JJ 964 975 replication replication NN 975 976 . . . 977 982 These these DT 983 990 results result NNS 991 999 indicate indicate VBP 1000 1004 that that IN 1005 1007 in in IN 1008 1017 monocytic monocytic JJ 1018 1022 cell cell NN 1023 1030 lineage lineage NN 1030 1031 , , , 1032 1037 HIV-1 HIV-1 NNP 1038 1043 could could MD 1044 1049 mimic mimic VB 1050 1054 some some DT 1055 1081 differentiation/activation differentiation/activation NN 1082 1089 stimuli stimulus NNS 1090 1098 allowing allow VBG 1099 1106 nuclear nuclear JJ 1107 1112 NF-KB NF-KB NNP 1113 1123 expression expression NN 1123 1124 . . .