0 10 Comparison comparison NN 11 13 of of IN 14 26 constitutive constitutive JJ 27 30 and and CC 31 40 inducible inducible JJ 41 56 transcriptional transcriptional JJ 57 68 enhancement enhancement NN 69 77 mediated mediate VBN 78 80 by by IN 81 86 kappa kappa NN 87 96 B-related b-related JJ 97 106 sequences sequence NNS 106 107 : : : 108 118 modulation modulation NN 119 121 of of IN 122 130 activity activity NN 131 133 in in IN 134 135 B B NNP 136 141 cells cell NNS 142 144 by by IN 145 150 human human JJ 151 157 T-cell t-cell NN 158 166 leukemia leukemia NN 167 172 virus virus NN 173 177 type type NN 178 179 I i CD 180 183 tax tax NN 184 188 gene gene NN 188 189 . . . 191 194 The the DT 195 200 kappa kappa NN 201 202 B B NNP 203 211 sequence sequence NN 212 213 ( ( ( 213 223 GGGACTTTCC GGGACTTTCC NNP 223 224 ) ) ) 225 230 binds bind VBZ 231 232 a a DT 233 239 factor factor NN 239 240 , , , 241 249 NF-kappa NF-kappa NNP 250 251 B B NNP 251 252 , , , 253 257 that that WDT 258 260 is be VBZ 261 275 constitutively constitutively RB 276 281 found find VBN 282 284 in in IN 285 288 its its PRP$ 289 299 functional functional JJ 299 300 , , , 301 304 DNA DNA NNP 305 312 binding binding NN 313 317 form form NN 318 322 only only RB 323 325 in in IN 326 327 B B NNP 328 339 lymphocytes lymphocyte NNS 339 340 . . . 341 342 A a DT 343 349 factor factor NN 350 354 with with IN 355 365 apparently apparently RB 366 383 indistinguishable indistinguishable JJ 384 392 sequence sequence NN 393 404 specificity specificity NN 405 408 can can MD 409 411 be be VB 412 419 induced induce VBN 420 422 in in IN 423 427 many many JJ 428 433 other other JJ 434 438 cell cell NN 439 444 types type NNS 444 445 , , , 446 451 where where WRB 452 454 it it PRP 455 457 is be VBZ 458 462 used use VBN 463 465 to to TO 466 474 regulate regulate VB 475 484 inducible inducible JJ 485 489 gene gene NN 490 500 expression expression NN 500 501 . . . 502 505 For for IN 506 513 example example NN 513 514 , , , 515 520 kappa kappa NN 521 530 B-related b-related JJ 531 540 sequences sequence NNS 541 545 have have VBP 546 550 been be VBN 551 556 shown show VBN 557 559 to to TO 560 562 be be VB 563 572 important important JJ 573 576 for for IN 577 580 the the DT 581 594 transcription transcription NN 595 597 of of IN 598 599 a a DT 600 603 few few JJ 604 613 inducible inducible JJ 614 619 genes gene NNS 619 620 , , , 621 625 such such JJ 626 628 as as IN 629 632 the the DT 633 644 interleukin interleukin NN 645 646 2 2 CD 647 655 receptor receptor NN 656 667 alpha-chain alpha-chain NN 668 672 gene gene NN 673 676 and and CC 677 680 the the DT 681 696 beta-interferon beta-interferon NN 697 701 gene gene NN 701 702 . . . 703 710 However however RB 710 711 , , , 712 717 these these DT 718 723 genes gene NNS 724 727 are be VBP 728 731 not not RB 732 746 constitutively constitutively RB 747 753 active active JJ 754 756 in in IN 757 758 B B NNP 759 770 lymphocytes lymphocyte NNS 770 771 , , , 772 782 suggesting suggest VBG 783 787 that that IN 788 793 other other JJ 794 804 regulatory regulatory JJ 805 815 mechanisms mechanism NNS 816 820 must must MD 821 825 play play VB 826 827 a a DT 828 832 role role NN 833 835 in in IN 836 847 determining determine VBG 848 851 the the DT 852 860 patterns pattern NNS 861 863 of of IN 864 874 expression expression NN 874 875 . . . 876 878 We we PRP 879 883 have have VBP 884 896 investigated investigate VBN 897 900 the the DT 901 913 constitutive constitutive JJ 914 917 and and CC 918 927 inducible inducible JJ 928 943 transcriptional transcriptional JJ 944 952 activity activity NN 953 961 mediated mediate VBN 962 964 by by IN 965 969 five five CD 970 975 kappa kappa NN 976 985 B-related b-related JJ 986 994 sequence sequence NN 995 1003 elements element NNS 1004 1006 in in IN 1007 1010 two two CD 1011 1020 different different JJ 1021 1025 cell cell NN 1026 1031 types type NNS 1031 1032 . . . 1033 1035 We we PRP 1036 1040 show show VBP 1041 1045 that that IN 1046 1048 in in IN 1049 1053 S194 s194 NN 1054 1060 plasma plasma NN 1061 1066 cells cell NNS 1067 1070 the the DT 1071 1079 activity activity NN 1080 1082 of of IN 1083 1087 each each DT 1088 1095 element element NN 1096 1106 correlates correlate VBZ 1107 1111 well well RB 1112 1116 with with IN 1117 1120 the the DT 1121 1129 relative relative JJ 1130 1138 affinity affinity NN 1139 1141 of of IN 1142 1156 B-cell-derived b-cell-derived JJ 1157 1165 NF-kappa NF-kappa NNP 1166 1167 B B NNP 1168 1171 for for IN 1172 1176 that that DT 1177 1184 element element NN 1184 1185 . . . 1186 1190 This this DT 1191 1196 leads lead VBZ 1197 1199 to to TO 1200 1213 significantly significantly RB 1214 1219 lower low JJR 1220 1233 transcription transcription NN 1234 1245 enhancement enhancement NN 1246 1248 by by IN 1249 1254 sites site NNS 1255 1262 derived derive VBN 1263 1267 from from IN 1268 1271 the the DT 1272 1283 interleukin interleukin NN 1284 1285 2 2 CD 1286 1294 receptor receptor NN 1295 1297 or or CC 1298 1304 T-cell t-cell NN 1305 1313 receptor receptor NN 1314 1319 genes gene NNS 1320 1322 in in IN 1323 1327 S194 s194 NN 1328 1333 cells cell NNS 1333 1334 . . . 1335 1342 However however RB 1342 1343 , , , 1344 1346 in in IN 1347 1353 either either CC 1354 1358 EL-4 el-4 NN 1359 1360 ( ( ( 1360 1361 T t NN 1361 1362 ) ) ) 1363 1368 cells cell NNS 1369 1371 or or CC 1372 1376 S194 s194 NN 1377 1382 cells cell NNS 1382 1383 , , , 1384 1388 both both DT 1389 1403 lower-affinity lower-affinity JJ 1404 1409 sites site NNS 1410 1413 can can MD 1414 1416 be be VB 1417 1430 significantly significantly RB 1431 1438 induced induce VBN 1439 1441 by by IN 1442 1445 the the DT 1446 1449 tax tax NN 1450 1454 gene gene NN 1455 1462 product product NN 1463 1465 of of IN 1466 1471 human human JJ 1472 1478 T-cell t-cell NN 1479 1487 leukemia leukemia NN 1488 1493 virus virus NN 1494 1498 type type NN 1499 1500 I i CD 1500 1501 , , , 1502 1509 showing show VBG 1510 1514 that that IN 1515 1523 NF-kappa NF-kappa NNP 1524 1525 B B NNP 1526 1534 activity activity NN 1535 1538 can can MD 1539 1541 be be VB 1542 1551 modulated modulate VBN 1552 1556 even even RB 1557 1559 in in IN 1560 1561 a a DT 1562 1568 B-cell b-cell NN 1569 1573 line line NN 1574 1578 that that WDT 1579 1593 constitutively constitutively RB 1594 1603 expresses express VBZ 1604 1608 this this DT 1609 1615 factor factor NN 1615 1616 . . .