0 6 Murine murine JJ 7 10 and and CC 11 16 human human JJ 17 29 T-lymphocyte T-lymphocyte NNP 30 36 GATA-3 gata-3 NN 37 44 factors factor NNS 45 52 mediate mediate VBP 53 66 transcription transcription NN 67 74 through through IN 75 76 a a DT 77 91 cis-regulatory cis-regulatory JJ 92 99 element element NN 100 106 within within IN 107 110 the the DT 111 116 human human JJ 117 123 T-cell t-cell NN 124 132 receptor receptor NN 133 138 delta delta NN 139 143 gene gene NN 144 152 enhancer enhancer NN 152 153 . . . 155 156 A a DT 157 163 family family NN 164 166 of of IN 167 182 transcriptional transcriptional JJ 183 193 activators activator NNS 194 197 has have VBZ 198 206 recently recently RB 207 211 been be VBN 212 222 identified identify VBN 223 225 in in IN 226 234 chickens chicken NNS 234 235 ; ; : 236 241 these these DT 242 257 transcriptional transcriptional JJ 258 268 activators activator NNS 269 278 recognize recognize VBP 279 280 a a DT 281 287 common common JJ 288 297 consensus consensus NN 298 303 motif motif NN 304 305 ( ( ( 305 311 WGATAR WGATAR NNP 311 312 ) ) ) 313 320 through through IN 321 322 a a DT 323 332 conserved conserve VBN 333 335 C4 c4 NN 336 340 zinc zinc NN 341 347 finger finger NN 348 359 DNA-binding dna-binding JJ 360 366 domain domain NN 366 367 . . . 368 371 One one CD 372 374 of of IN 375 378 the the DT 379 386 members member NNS 387 389 of of IN 390 394 this this DT 395 404 multigene multigene JJ 405 411 family family NN 411 412 , , , 413 420 cGATA-3 cgata-3 NN 420 421 , , , 422 424 is be VBZ 425 429 most most RBS 430 440 abundantly abundantly RB 441 450 expressed express VBN 451 453 in in IN 454 457 the the DT 458 470 T-lymphocyte T-lymphocyte NNP 471 475 cell cell NN 476 483 lineage lineage NN 483 484 . . . 485 493 Analysis Analysis NNP 494 496 of of IN 497 502 human human JJ 503 506 and and CC 507 513 murine murine JJ 514 520 GATA-3 gata-3 NN 521 528 factors factor NNS 529 534 shows show VBZ 535 536 a a DT 537 545 striking striking JJ 546 552 degree degree NN 553 555 of of IN 556 561 amino amino JJ 562 566 acid acid NN 567 575 sequence sequence NN 576 584 identity identity NN 585 588 and and CC 589 596 similar similar JJ 597 605 patterns pattern NNS 606 608 of of IN 609 615 tissue tissue NN 616 627 specificity specificity NN 628 630 of of IN 631 641 expression expression NN 642 644 in in IN 645 650 these these DT 651 656 three three CD 657 666 organisms organism NNS 666 667 . . . 668 671 The the DT 672 678 murine murine JJ 679 682 and and CC 683 688 human human JJ 689 696 factors factor NNS 697 700 are be VBP 701 711 abundantly abundantly RB 712 721 expressed express VBN 722 724 in in IN 725 726 a a DT 727 734 variety variety NN 735 737 of of IN 738 743 human human JJ 744 747 and and CC 748 754 murine murine JJ 755 761 T-cell t-cell NN 762 767 lines line NNS 768 771 and and CC 772 775 can can MD 776 784 activate activate VB 785 798 transcription transcription NN 799 806 through through IN 807 808 a a DT 809 824 tissue-specific tissue-specific JJ 825 837 GATA-binding gata-binding JJ 838 842 site site NN 843 853 identified identify VBN 854 860 within within IN 861 864 the the DT 865 870 human human JJ 871 877 T-cell t-cell NN 878 886 receptor receptor NN 887 892 delta delta NN 893 897 gene gene NN 898 906 enhancer enhancer NN 906 907 . . . 908 910 We we PRP 911 916 infer infer VBP 917 921 that that IN 922 925 the the DT 926 932 murine murine JJ 933 936 and and CC 937 942 human human JJ 943 949 GATA-3 gata-3 NN 950 958 proteins protein NNS 959 963 play play VBP 964 965 a a DT 966 973 central central JJ 974 977 and and CC 978 984 highly highly RB 985 994 conserved conserve VBN 995 999 role role NN 1000 1002 in in IN 1003 1013 vertebrate vertebrate NN 1014 1029 T-cell-specific t-cell-specific JJ 1030 1045 transcriptional transcriptional JJ 1046 1056 regulation regulation NN 1056 1057 . . .