0 10 Processing processing NN 11 13 of of IN 14 17 the the DT 18 27 precursor precursor NN 28 30 of of IN 31 39 NF-kappa NF-kappa NNP 40 41 B B NNP 42 44 by by IN 45 48 the the DT 49 54 HIV-1 HIV-1 NNP 55 63 protease protease NN 64 70 during during IN 71 76 acute acute JJ 77 86 infection infection NN 86 87 . . . 89 102 Transcription transcription NN 103 105 of of IN 106 109 the the DT 110 115 human human JJ 116 132 immunodeficiency immunodeficiency NN 133 138 virus virus NN 139 145 type-1 type-1 NN 146 147 ( ( ( 147 152 HIV-1 HIV-1 NNP 152 153 ) ) ) 154 160 genome genome NN 161 163 is be VBZ 164 173 regulated regulate VBN 174 176 in in IN 177 181 part part NN 182 184 by by IN 185 193 cellular cellular JJ 194 201 factors factor NNS 202 205 and and CC 206 208 is be VBZ 209 219 stimulated stimulate VBN 220 222 by by IN 223 233 activation activation NN 234 236 of of IN 237 245 latently latently RB 246 254 infected infected JJ 255 256 T t NN 257 262 cells cell NNS 262 263 . . . 264 270 T-cell t-cell NN 271 281 activation activation NN 282 286 also also RB 287 297 correlates correlate VBZ 298 302 with with IN 303 306 the the DT 307 316 induction induction NN 317 319 of of IN 320 323 the the DT 324 330 factor factor NN 331 339 NF-kappa NF-kappa NNP 340 341 B B NNP 342 347 which which WDT 348 353 binds bind VBZ 354 356 to to TO 357 360 two two CD 361 369 adjacent adjacent JJ 370 375 sites site NNS 376 378 in in IN 379 382 the the DT 383 388 HIV-1 HIV-1 NNP 389 393 long long JJ 394 402 terminal terminal JJ 403 409 repeat repeat NN 409 410 . . . 411 415 This this DT 416 422 factor factor NN 423 431 consists consist VBZ 432 434 of of IN 435 438 two two CD 439 450 DNA-binding dna-binding JJ 451 459 subunits subunit NNS 460 462 of of IN 463 471 relative relative JJ 472 481 molecular molecular JJ 482 486 mass mass NN 487 493 50,000 50,000 CD 494 495 ( ( ( 495 498 50K 50k CD 498 499 ) ) ) 500 510 associated associate VBN 511 515 with with IN 516 519 two two CD 520 523 65K 65k CD 524 532 subunits subunit NNS 532 533 . . . 534 536 It it PRP 537 539 is be VBZ 540 547 located locate VBN 548 550 in in IN 551 554 the the DT 555 562 nucleus nucleus NN 563 565 in in IN 566 572 mature mature JJ 573 574 B B NNP 575 580 cells cell NNS 580 581 , , , 582 585 but but CC 586 588 is be VBZ 589 596 present present JJ 597 599 in in IN 600 605 other other JJ 606 610 cell cell NN 611 616 types type NNS 617 619 as as IN 620 622 an an DT 623 631 inactive inactive JJ 632 643 cytoplasmic cytoplasmic JJ 644 651 complex complex NN 651 652 . . . 653 661 External external JJ 662 669 stimuli stimulus NNS 669 670 , , , 671 680 including include VBG 681 686 those those DT 687 691 that that WDT 692 700 activate activate VBP 701 702 T t NN 703 708 cells cell NNS 708 709 , , , 710 716 result result VBP 717 719 in in IN 720 727 nuclear nuclear JJ 728 741 translocation translocation NN 742 744 of of IN 745 751 active active JJ 752 760 NF-kappa NF-kappa NNP 761 763 B. B. NNP 764 767 The the DT 768 775 cloning cloning NN 776 778 of of IN 779 782 the the DT 783 796 complementary complementary JJ 797 800 DNA dna NN 801 804 for for IN 805 808 the the DT 809 812 50K 50k NN 813 820 subunit subunit NN 821 827 helped help VBD 828 830 to to TO 831 839 identify identify VB 840 842 an an DT 843 854 exclusively exclusively RB 855 866 cytoplasmic cytoplasmic JJ 867 871 105K 105k CD 872 881 precursor precursor NN 882 883 ( ( ( 883 887 p105 p105 NN 887 888 ) ) ) 889 890 ( ( ( 890 894 V.B. V.B. NNP 894 895 , , , 896 900 P.K. P.K. NNP 901 904 and and CC 905 909 A.I. A.I. NNP 909 910 , , , 911 921 manuscript manuscript NN 922 931 submitted submit VBN 931 932 ) ) ) 932 933 . . . 934 937 The the DT 938 948 expression expression NN 949 951 of of IN 952 958 active active JJ 959 967 NF-kappa NF-kappa NNP 968 969 B B NNP 970 975 might might MD 976 985 therefore therefore RB 986 990 also also RB 991 993 be be VB 994 1003 regulated regulate VBN 1004 1006 by by IN 1007 1010 the the DT 1011 1017 extent extent NN 1018 1020 of of IN 1021 1031 processing processing NN 1032 1034 of of IN 1035 1039 p105 p105 NN 1039 1040 . . . 1041 1048 Because because IN 1049 1054 HIV-1 HIV-1 NNP 1055 1063 requires require VBZ 1064 1070 active active JJ 1071 1079 NF-kappa NF-kappa NNP 1080 1081 B B NNP 1082 1085 for for IN 1086 1095 efficient efficient JJ 1096 1109 transcription transcription NN 1109 1110 , , , 1111 1113 we we PRP 1114 1120 tested test VBD 1121 1124 the the DT 1125 1131 effect effect NN 1132 1134 of of IN 1135 1140 HIV-1 HIV-1 NNP 1141 1150 infection infection NN 1151 1153 on on IN 1154 1157 the the DT 1158 1168 processing processing NN 1169 1171 of of IN 1172 1175 the the DT 1176 1181 human human JJ 1182 1186 105K 105k CD 1187 1196 precursor precursor NN 1196 1197 . . . 1198 1200 We we PRP 1201 1205 show show VBP 1206 1210 here here RB 1211 1215 that that IN 1216 1219 the the DT 1220 1225 HIV-1 HIV-1 NNP 1226 1234 protease protease NN 1235 1238 can can MD 1239 1246 process process VB 1247 1251 p105 p105 NN 1252 1255 and and CC 1256 1265 increases increase VBZ 1266 1272 levels level NNS 1273 1275 of of IN 1276 1282 active active JJ 1283 1290 nuclear nuclear JJ 1291 1299 NF-kappa NF-kappa NNP 1300 1301 B B NNP 1302 1309 complex complex NN 1309 1310 . . .