0 7 Cloning cloning NN 8 10 of of IN 11 12 a a DT 13 30 mitogen-inducible mitogen-inducible JJ 31 35 gene gene NN 36 44 encoding encode VBG 45 46 a a DT 47 52 kappa kappa NN 53 54 B B NNP 55 66 DNA-binding dna-binding JJ 67 74 protein protein NN 75 79 with with IN 80 88 homology homology NN 89 91 to to TO 92 95 the the DT 96 99 rel rel NN 100 108 oncogene oncogene NN 109 112 and and CC 113 115 to to TO 116 126 cell-cycle cell-cycle JJ 127 133 motifs motif NNS 133 134 . . . 136 138 We we PRP 139 143 have have VBP 144 150 cloned clone VBN 151 154 and and CC 155 168 characterized characterize VBN 169 170 a a DT 171 188 mitogen-inducible mitogen-inducible JJ 189 193 gene gene NN 194 202 isolated isolate VBN 203 207 from from IN 208 213 human human JJ 214 215 T t NN 216 221 cells cell NNS 222 226 that that WDT 227 235 predicts predict VBZ 236 237 a a DT 238 245 protein protein NN 246 248 of of IN 249 252 968 968 CD 253 258 amino amino NN 259 264 acids acid NNS 264 265 . . . 266 269 The the DT 270 284 amino-terminal amino-terminal JJ 285 291 domain domain NN 292 295 has have VBZ 296 303 regions region NNS 304 314 homologous homologous JJ 315 317 to to TO 318 321 the the DT 322 330 oncogene oncogene NN 331 334 rel rel NN 335 338 and and CC 339 341 to to TO 342 345 the the DT 346 361 developmentally developmentally RB 362 371 important important JJ 372 376 gene gene NN 377 383 dorsal dorsal NN 384 386 of of IN 387 397 Drosophila drosophila FW 397 398 . . . 399 402 The the DT 403 419 carboxy-terminal carboxy-terminal JJ 420 426 domain domain NN 427 435 contains contain VBZ 436 442 repeat repeat NN 443 453 structures structure NNS 454 459 found find VBN 460 462 in in IN 463 464 a a DT 465 472 variety variety NN 473 475 of of IN 476 484 proteins protein NNS 485 489 that that WDT 490 493 are be VBP 494 502 involved involve VBN 503 505 in in IN 506 516 cell-cycle cell-cycle NN 517 524 control control NN 525 527 of of IN 528 533 yeast yeast NN 534 537 and and CC 538 540 in in IN 541 547 tissue tissue NN 548 563 differentiation differentiation NN 564 566 in in IN 567 577 Drosophila Drosophila NNP 578 581 and and CC 582 596 Ceanorhabditis Ceanorhabditis NNP 597 604 elegans elegans NNP 604 605 , , , 606 608 as as RB 609 613 well well RB 614 616 as as IN 617 619 in in IN 620 623 the the DT 624 632 putative putative JJ 633 638 human human JJ 639 647 oncogene oncogene NN 648 653 bcl-3 bcl-3 NN 654 657 and and CC 658 660 in in IN 661 664 the the DT 665 672 ankyrin ankyrin NN 673 680 protein protein NN 680 681 . . . 682 683 A a DT 684 693 truncated truncate VBN 694 698 form form NN 699 701 of of IN 702 705 the the DT 706 713 product product NN 714 716 of of IN 717 721 this this DT 722 726 gene gene NN 727 737 translated translate VBN 738 740 in in FW 741 746 vitro vitro FW 747 749 is be VBZ 750 751 a a DT 752 763 DNA-binding dna-binding JJ 764 771 protein protein NN 772 777 which which WDT 778 787 interacts interact VBZ 788 800 specifically specifically RB 801 805 with with IN 806 809 the the DT 810 815 kappa kappa NN 816 817 B B NNP 818 825 binding binding NN 826 830 site site NN 831 836 found find VBN 837 839 in in IN 840 844 many many JJ 845 854 inducible inducible JJ 855 860 genes gene NNS 860 861 , , , 862 871 including include VBG 872 875 the the DT 876 884 enhancer enhancer NN 885 887 in in IN 888 893 human human JJ 894 910 immunodeficiency immunodeficiency NN 911 916 virus virus NN 916 917 . . . 918 922 This this DT 923 927 gene gene NN 928 930 is be VBZ 931 934 yet yet RB 935 942 another another DT 943 945 in in IN 946 947 a a DT 948 955 growing grow VBG 956 960 list list NN 961 963 of of IN 964 973 important important JJ 974 984 regulatory regulatory JJ 985 994 molecules molecule NNS 995 1000 whose whose WP$ 1001 1011 expression expression NN 1012 1014 is be VBZ 1015 1032 transcriptionally transcriptionally RB 1033 1040 induced induce VBN 1041 1045 upon upon IN 1046 1054 cellular cellular JJ 1055 1065 activation activation NN 1065 1066 . . .